ZNF750, zinc finger protein 750, 79755

N. diseases: 20; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1853258
Disease: Seborrhea-Like Dermatitis with Psoriasiform Elements
Seborrhea-Like Dermatitis with Psoriasiform Elements 		0.600 Biomarker disease CTD_human
CUI: C0036508
Disease: Seborrheic dermatitis
Seborrheic dermatitis 		0.100 Biomarker disease HPO
CUI: C0870082
Disease: Hyperkeratosis
Hyperkeratosis 		0.100 Biomarker disease HPO
CUI: C4553962
Disease: Hyperkeratosis, CTCAE
Hyperkeratosis, CTCAE 		0.100 Biomarker phenotype HPO
CUI: C1853258
Disease: Seborrhea-Like Dermatitis with Psoriasiform Elements
Seborrhea-Like Dermatitis with Psoriasiform Elements 		0.600 GermlineCausalMutation disease ORPHANET Seborrhea-like dermatitis with psoriasiform elements caused by a mutation in ZNF750, encoding a putative C2H2 zinc finger protein. 16751772 2006
CUI: C1853258
Disease: Seborrhea-Like Dermatitis with Psoriasiform Elements
Seborrhea-Like Dermatitis with Psoriasiform Elements 		0.600 Biomarker disease GENOMICS_ENGLAND Seborrhea-like dermatitis with psoriasiform elements caused by a mutation in ZNF750, encoding a putative C2H2 zinc finger protein. 16751772 2006
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.060 Biomarker group BEFREE ZNF750 is a lineage-specific tumour suppressor in squamous cell carcinoma. 27819679 2017
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.040 Biomarker disease BEFREE ZNF750 is a lineage-specific tumour suppressor in squamous cell carcinoma. 27819679 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.060 Biomarker group BEFREE ZNF750, an epidermal differentiation regulator, has been suggested to act as a tumor suppressor of esophageal squamous cell carcinoma (ESCC). 28558382 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.060 AlteredExpression group BEFREE ZNF750, a transcriptional regulator of epidermal differentiation, has been identified as a tumor suppressor in esophageal squamous cell carcinoma (ESCC). 29216641 2018
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.030 Biomarker group BEFREE Zinc-finger protein 750 (ZNF750) is the potential anti-cancer gene in oral squamous cell carcinoma (OSCC). 29416636 2018
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.030 Biomarker group BEFREE Zinc-finger protein 750 (ZNF750) is the potential anti-cancer gene in oral squamous cell carcinoma (OSCC). 29416636 2018
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.040 Biomarker disease BEFREE ZNF750 inhibited the malignant progression of oral squamous cell carcinoma by regulating tumor vascular microenvironment. 29890464 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.060 Biomarker group BEFREE ZNF750 could modulate the tumor vascular microenvironment to inhibit the oral squamous cells carcinoma malignant progression. 29890464 2018
CUI: C0007097
Disease: Carcinoma
Carcinoma 		0.010 Biomarker group BEFREE ZNF750 could modulate the tumor vascular microenvironment to inhibit the oral squamous cells carcinoma malignant progression. 29890464 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.060 Biomarker group BEFREE Zinc-finger protein 750 (ZNF750) is a potential tumor suppressor in oral squamous cell carcinoma (OSCC). 31545271 2019
CUI: C1853258
Disease: Seborrhea-Like Dermatitis with Psoriasiform Elements
Seborrhea-Like Dermatitis with Psoriasiform Elements 		0.600 Biomarker disease GENOMICS_ENGLAND Association analysis identifies ZNF750 regulatory variants in psoriasis. 22185198 2011
CUI: C0279626
Disease: Squamous cell carcinoma of esophagus
Squamous cell carcinoma of esophagus 		0.060 GeneticVariation disease BEFREE Combined analysis from current and previous genomic ESCC studies indicated more frequent ZNF750 mutation in diagnosed cases with LN metastasis than in those without metastasis (14% versus 3.4%, n = 629, P = 1.78 × 10<sup>-5</sup> ). 28608921 2017
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.020 GeneticVariation phenotype BEFREE Combined analysis from current and previous genomic ESCC studies indicated more frequent ZNF750 mutation in diagnosed cases with LN metastasis than in those without metastasis (14% versus 3.4%, n = 629, P = 1.78 × 10<sup>-5</sup> ). 28608921 2017
CUI: C0279626
Disease: Squamous cell carcinoma of esophagus
Squamous cell carcinoma of esophagus 		0.060 Biomarker disease BEFREE Functional analyses suggest roles for several genes (CBX4, CBX8, AJUBA, and ZNF750) in ESCC. 25839328 2015
CUI: C0406709
Disease: Hay-Wells syndrome
Hay-Wells syndrome 		0.010 Biomarker disease BEFREE Genomic profiling of a human organotypic model of AEC syndrome reveals ZNF750 as an essential downstream target of mutant TP63. 22922031 2012
CUI: C0686619
Disease: Secondary malignant neoplasm of lymph node
Secondary malignant neoplasm of lymph node 		0.010 AlteredExpression disease BEFREE Low ZNF750 expression had a significant correlation with positive lymph node metastasis (p = 0.028). 29216641 2018
CUI: C0262985
Disease: Psoriasiform eczema
Psoriasiform eczema 		0.010 GeneticVariation disease BEFREE Mutations in the ZNF750 promoter and coding regions have been previously associated with Mendelian forms of psoriasis and psoriasiform dermatitis. 22185198 2011
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.060 AlteredExpression group BEFREE Overexpression of tumor suppressor gene ZNF750 inhibits oral squamous cell carcinoma metastasis. 29113187 2017
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.040 Biomarker disease BEFREE Overexpression of tumor suppressor gene ZNF750 inhibits oral squamous cell carcinoma metastasis. 29113187 2017