|
Bronchial Hyperreactivity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymorphic variation in ADAM33 is strongly associated with asthma and bronchial hyperresponsiveness.
|
14742294 |
2004 |
|
Bronchial Hyperreactivity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A disintegrin and metalloprotease 33 (ADAM33) polymorphism is strongly associated with asthma and bronchial hyperresponsiveness.
|
18423563 |
2008 |
|
Bronchial Hyperreactivity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness.
|
12110844 |
2002 |
|
Bronchial Hyperreactivity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The ADAM33 gene has recently been identified as being a potentially important asthma candidate gene, and polymorphisms in this gene have been shown to be associated with asthma and bronchial hyperresponsiveness in Caucasian individuals from several populations.
|
16773130 |
2006 |
|
Malignant neoplasm of breast
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
This study suggests that metabolites of phthalate such as MEHHP, MECPP, MEOHP and Σ4MEHP may increase the intron 1 methylation level to elevate ADAM33 gene expression and have a protective effect on reducing the risk of breast cancer.
|
30226539 |
2018 |
|
Breast Carcinoma
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
This study suggests that metabolites of phthalate such as MEHHP, MECPP, MEOHP and Σ4MEHP may increase the intron 1 methylation level to elevate ADAM33 gene expression and have a protective effect on reducing the risk of breast cancer.
|
30226539 |
2018 |
|
Stage IV Skin Melanoma
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis demonstrates that the ADAM33 S2 polymorphism confers susceptibility to asthma in Europeans and the ADAM33 ST+4 polymorphism is associated with asthma in Asians and adults.
|
23612257 |
2013 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results detected a significant association between ADAM33 T2, Q1, F + 1 and AA genotype of T + 1 polymorphisms and asthma risk in total population.
|
30791911 |
2019 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Haplotypic association of ADAM33 (T+1, S+1 and V - 3) gene variants in genetic susceptibility to asthma in Indian population.
|
22989201 |
2013 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A recent study has identified the variation in the ADAM33 gene as an important risk factor for asthma.
|
12401189 |
2002 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of the ADAM33 gene predict excess decline in lung function, in asthma as well as at population level.
|
18188020 |
2008 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Three SNPs (F + 1, T1, and T2) of ADAM33 were found to have significant associations with asthma in the study population (p = .0058-.0067).
|
22035178 |
2011 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To assess whether SNPs or haplotypes of ADAM33 are related to asthma in a Chinese Han population, we genotyped three SNPs of ADAM33 (7575G/A in intron 6, 11188A/T in intron 19, and 12433T/C in exon 20) in a case-control study involving 296 patients with asthma and 270 healthy controls.
|
16893396 |
2006 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We sought to determine whether polymorphisms in ADAM33 are associated with asthma or closely related phenotypes in 4 different asthma populations.
|
14564349 |
2003 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
As rs44707 and rs2787094 are associated with asthma and a distinctive palm pattern, the data suggest that ADAM33 polymorphisms are correlated with asthma and may be the underlying genetic basis of the association between asthma and palm dermatoglyphic patterns.
|
24141861 |
2013 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
These data provide for the first time a functional role for a disease-associated SNP in ADAM33 and begin to shed light on the deregulation of this gene in the pathophysiology of asthma.
|
17640346 |
2007 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We conclude that the ADAM33 gene is not an important risk factor for asthma or for asthma-associated phenotypes in Mexicans or in Puerto Ricans.
|
12958057 |
2003 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Seventeen ADAM33 single nucleotide polymorphisms (SNPs; including 9 associated with asthma in the initial report) were genotyped by mass spectrometry.
|
15208587 |
2004 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study found no association between the methylation of CpG sites in exon 9 of the ADAM33 gene and adult asthma.
|
23257708 |
2013 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We illustrate the application of random forests with a data set of asthma cases and unaffected controls genotyped at 42 SNPs in ADAM33, a previously identified asthma susceptibility gene.
|
15593090 |
2005 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association between V4 polymorphism in the ADAM33 gene and asthma risk: a meta-analysis.
|
25730038 |
2015 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Strong LD was found among rs678881, rs2280089 and rs2853209, and haplotype GGT was distinctly associated with the risk of asthma in children (OR = 0.28, 95%CI = 0.13-0.57).ADAM33 rs678881 polymorphism is significantly correlated with increased susceptibility to asthma in Chinese Han children.
|
31626088 |
2019 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These data provide for the first time a functional role for a disease-associated SNP in ADAM33 and begin to shed light on the deregulation of this gene in the pathophysiology of asthma.
|
17640346 |
2007 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
A survey of 135 polymorphisms in 23 genes identified the ADAM33 gene as being significantly associated with asthma using case-control, transmission disequilibrium and haplotype analyses (P = 0.04 0.000003).
|
12110844 |
2002 |