|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Variation in ADAM33 has been shown to be important in the development of asthma and altered lung function.
|
19284602 |
2009 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The current study aims to evaluate the association of ADAM33 gene polymorphisms with the risk of asthma in the Punjabi population of Pakistan.
|
26666372 |
2016 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We examined whether polymorphisms in ADAM33 are associated with asthma and related traits in two German populations.
|
14720258 |
2004 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that a variant in ADAM33 is not only important in the development of asthma but also in disease progression, possibly related to enhanced airway remodelling.
|
15144468 |
2004 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results replicate associations reported recently in other ethnic populations, and suggest that the ADAM33 gene is involved in the development of asthma through genetic polymorphisms.
|
16839403 |
2006 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Meta-analyses have been performed for polymorphisms in 5 genes and provide modest evidence for genetic association of asthma with ADAM33 and TNFA gene polymorphisms.
|
17190999 |
2007 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The ADAM33 rs528557/S2 and the VEGFA rs833069 SNPs were associated with Thai asthmatics, as well as with other populations worldwide.
|
31586488 |
2019 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
ADAM33 SNP rs612709 and the CCGGAAGA haplotype may be associated with asthma.
|
22583515 |
2012 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recently, it has been reported that a peptide derived from APP is cleaved by alpha disintegrin and metalloproteinase 33 (ADAM33), which is an asthma susceptibility gene.
|
20513247 |
2010 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The genotypes and allele frequencies of SNPs S2 and ST+5 of the ADAM33 gene were significantly associated with asthma risk (P = 0.020 - < 0.001), whereas F+1, ST+4, V4 homozygous mutant genotypes and mutant alleles were significantly associated with increased asthma risk (P = 0.031 - < 0.001).
|
21179102 |
2011 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To assess whether genetic variants of ADAM33 are related to asthma in a Korean population, we conducted an association study of the ADAM33 gene with asthma susceptibility, bronchial hyper-reactivity and serum IgE in Korean asthmatics (n=326) and normal controls (n=151).
|
15196271 |
2004 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The objective of this study was to determine the association, if any, between ADAM33 polymorphisms and asthma in Thai subjects.
|
19317339 |
2008 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The SNPs (V4 G/C, T2 A/G, T1 G/A, and Q - 1A/G) of the ADAM33 gene may be the causal variants in ARA disease.
|
18752037 |
2009 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The A disintegrin and metalloproteinase 33 (ADAM33) gene, located on chromosome 20p13, has recently been identified as an asthma-susceptibility gene by positional cloning.
|
20491578 |
2010 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This interaction was notable in that rs910652 is located within 78 kilobases of ADAM33, which is one of the most well studied asthma susceptibility genes.
|
27387956 |
2016 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Haplotype analyses suggested a minor effect of the ADAM33 haplotype H4 on asthma (p = 0.033) but not on BHR.
|
16784537 |
2006 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recently, the polymorphisms in Adam33 have been found to be associated with asthma.
|
12768445 |
2003 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In agreement with some other studies in different populations, our results showed no association between frequency of genotype or alleles of both T1 and V4 SNPs in ADAM33 gene and predisposition to asthma in Azerbaijan population of Iran.
|
29149777 |
2017 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We identified five single nucleotide polymorphisms on three genes previously associated with asthma [interleukin (IL)-4RA, IL-13, ADAM33] and one gene associated with inflammation (cyclooxygenase-2).
|
16024651 |
2005 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of ADAM33 gene polymorphisms with asthma in Mongolian and Han groups in Inner Mongolia.
|
30591802 |
2018 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to evaluate the potential relationship between polymorphisms of ADAM33 and asthma in a Han population in China.
|
21689380 |
2013 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis demonstrates that the ADAM33 T1 polymorphism confers susceptibility to asthma in Asians, but no association was found between the ADAM33 T2 and ST+7 polymorphisms and asthma susceptibility.
|
22851202 |
2012 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No significant association was found between the ADAM33 rs3918396 G>A polymorphism and the risk of asthma among the studied ethnicities (All p>0.05).
|
25068505 |
2014 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The T1 (TC) and V4 (GG) genotypes in the ADAM33 gene were associated with significantly decreased FEV1 levels in patients with asthma.
|
25036518 |
2014 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis provides evidence that the T1, V4, F+1, T2, and T+1 polymorphisms in the ADAM33 gene are risk factors for asthma, especially in the Asian population.
|
23380143 |
2013 |