|
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We investigated whether the levels of survivin and caspase 8 and the ratio between these 2 apoptotic factors correlate with tumor biology and predicts outcome in patients with neuroblastoma.
|
16825985 |
2006 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Caspase-8 silenced N-type invasive NB cell lines LAN-1 and IMR-32 were investigated for their sensitivity to dox, and compared to S-type noninvasive SH-EP NB cells expressing caspase-8.
|
12203125 |
2002 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, gemcitabine-induced apoptosis was observed irrespective of the caspase-8 status of neuroblastoma cells, which indicates that apoptosis depends on the mitochondrial pathway.
|
15867251 |
2005 |
|
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These data indicate that the pattern of expression of these neural-enriched IG20-SVs regulates the expression and activation of caspase-8 in certain neuroblastoma cells, and that manipulation of IG20-SV expression pattern may represent a potent therapeutic strategy in the therapy of neuroblastoma and perhaps other cancers.
|
18794122 |
2008 |
|
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We sought to determine whether caspase 8l is present in neuroblastoma and whether over-expression of this protein could inhibit caspase 8-dependent apoptosis.
|
16374545 |
2006 |
|
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Thus, by demonstrating that 5-dAzaC and IFN-gamma at relatively low individual concentrations cooperate to restore caspase-8 expression and sensitize resistant neuroblastoma and medulloblastoma cells to TRAIL-induced apoptosis, our findings have important implications for novel strategies targeting defective apoptosis pathways in neuroectodermal tumors.
|
16607283 |
2006 |
|
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
An interferon-sensitive response element is involved in constitutive caspase-8 gene expression in neuroblastoma cells.
|
17036321 |
2007 |
|
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The authors found that interferon-gamma induces caspase-8 expression in neuroblastoma cells irrespective of the gene silenced by hypermethylation of caspase-8 promoter.
|
15065018 |
2004 |
|
Central neuroblastoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Detection of CpG island hypermethylation of caspase-8 in neuroblastoma using an oligonucleotide array.
|
19260109 |
2009 |
|
Central neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
CASP8 defects therefore represent an independent event in neuroblastoma, counteracting the N-myc induced susceptibility to apoptosis.
|
12880977 |
2003 |
|
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results indicate that the profile of caspase 8 expression is an important determinant of the response of neuroblastoma cells to Fas-mediated cell death.
|
12841868 |
2003 |
|
Central neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
By revealing no correlation between caspase-8 expression and MYCN amplification or other established variables of aggressive disease, our findings in a large cohort of neuroblastoma patients show that inactivation of caspase-8 is not a characteristic feature of aggressive neuroblastoma.
|
17047064 |
2006 |
|
Central neuroblastoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Sixty-two NBs (45 primary tumors and 17 NBs at relapse) were studied in terms of the methylation status of 19 genes (p15INK4a, p16INK4a, p14ARF, APC, RB1, RASSF1A, BLU, FHIT, RARbeta, INI1, TIMP3, NF2, MGMT, DAPK, FLIP, ECAD, CASP8, and the receptors DcR1 and DcR2).
|
17570703 |
2008 |