RGS5, regulator of G protein signaling 5, 8490

N. diseases: 52; N. variants: 5
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0085580
Disease: Essential Hypertension
Essential Hypertension 		0.320 Biomarker disease CTD_human
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.550 Therapeutic group CTD_human [A muscle mutant of Drosophila melanogaster: the electron microscopic study of the indirect flight musculature]. 1798635 1992
CUI: C0007134
Disease: Renal Cell Carcinoma
Renal Cell Carcinoma 		0.020 AlteredExpression disease BEFREE Northern analysis further confirmed the up-regulation in expression of RGS-5 and Notch-3 in RCC. 11072240 2000
CUI: C0279702
Disease: Conventional (Clear Cell) Renal Cell Carcinoma
Conventional (Clear Cell) Renal Cell Carcinoma 		0.020 AlteredExpression disease BEFREE Northern analysis further confirmed the up-regulation in expression of RGS-5 and Notch-3 in RCC. 11072240 2000
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.020 Biomarker disease BEFREE Genes of regulator of G-protein signaling 5 in neuroblastoma cells and CHC1-L in lymphocytes increased after exposure to hydrostatic pressure. 14504426 2003
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma 		0.020 Biomarker disease BEFREE Genes of regulator of G-protein signaling 5 in neuroblastoma cells and CHC1-L in lymphocytes increased after exposure to hydrostatic pressure. 14504426 2003
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma 		0.020 Biomarker disease BEFREE Genes of regulator of G-protein signaling 5 in neuroblastoma cells and CHC1-L in lymphocytes increased after exposure to hydrostatic pressure. 14504426 2003
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.060 Biomarker group BEFREE Immunohistochemical staining using serial sections for endothelial cell markers (CD31 and CD34) and smooth muscle cell markers (alpha-SMA and desmin), as well as fluorescence double staining, strongly suggested that tumour endothelial cells were the main location of RGS5 in RCC. 15095478 2004
CUI: C0007134
Disease: Renal Cell Carcinoma
Renal Cell Carcinoma 		0.020 Biomarker disease BEFREE Immunohistochemical staining using serial sections for endothelial cell markers (CD31 and CD34) and smooth muscle cell markers (alpha-SMA and desmin), as well as fluorescence double staining, strongly suggested that tumour endothelial cells were the main location of RGS5 in RCC. 15095478 2004
CUI: C0279702
Disease: Conventional (Clear Cell) Renal Cell Carcinoma
Conventional (Clear Cell) Renal Cell Carcinoma 		0.020 Biomarker disease BEFREE Immunohistochemical staining using serial sections for endothelial cell markers (CD31 and CD34) and smooth muscle cell markers (alpha-SMA and desmin), as well as fluorescence double staining, strongly suggested that tumour endothelial cells were the main location of RGS5 in RCC. 15095478 2004
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.050 Biomarker disease BEFREE Studies conducted to localize the protein products of these genes by immunohistochemical staining of tissue arrays with up to 350 cores of tissues, and by in situ hybridization led to the discovery of novel sinusoidal endothelial cell markers in hepatocellular carcinoma: podocalyxin-like and regulator of G protein signaling-5. 15154008 2004
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.060 AlteredExpression group BEFREE Similarly, RGS-5 is overexpressed in highly angiogenic astrocytomas but not in hypoxia-inducible factor-1alpha (HIF-1alpha)-deficient tumors, which grow along preexisting brain capillaries without inducing neovessels. 15459006 2005
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.020 AlteredExpression phenotype BEFREE Elevated levels of RGS-5 in pericytes are also observed during wound healing and ovulation indicating a strong correlation between RGS-5 expression and active vessel remodeling beyond tumor angiogenesis. 15459006 2005
CUI: C0004114
Disease: Astrocytoma
Astrocytoma 		0.010 AlteredExpression disease BEFREE Similarly, RGS-5 is overexpressed in highly angiogenic astrocytomas but not in hypoxia-inducible factor-1alpha (HIF-1alpha)-deficient tumors, which grow along preexisting brain capillaries without inducing neovessels. 15459006 2005
CUI: C1510885
Disease: Angiogenic Switch
Angiogenic Switch 		0.010 Biomarker disease BEFREE In a mouse model of pancreatic islet cell carcinogenesis, RGS-5 is specifically induced in the vasculature of premalignant lesions during the "angiogenic switch" and further elevated in tumor vessels. 15459006 2005
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.020 Biomarker disease LHGDN Expression profiling identifies smooth muscle cell diversity within human intima and plaque fibrous cap: loss of RGS5 distinguishes the cap. 16293795 2006
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.310 Biomarker disease PSYGENET RGS2 and RGS5 genotypes predicted severity of baseline symptoms in schizophrenia. 18262772 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.310 GeneticVariation disease BEFREE RGS2 and RGS5 genotypes predicted severity of baseline symptoms in schizophrenia. 18262772 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.310 GeneticVariation disease LHGDN RGS2 and RGS5 genotypes predicted severity of baseline symptoms in schizophrenia. 18262772 2008
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.020 Biomarker phenotype BEFREE Identification of regulator of G protein signaling 5 (RGS5) as a key modulator of the vascular barrier in tumor progression and regression has brought new insights into the molecular basis of vessel normalization and opens new therapeutic opportunities. 18719382 2008
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.060 Biomarker group BEFREE One family member, RGS5, has recently been identified as a key regulator of vascular remodeling and pericyte maturation in tumors. 19467451 2009
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.550 Biomarker group BEFREE Multiple SNPs in combination in RGS5 may confer risk for hypertension. 19863299 2009
CUI: C0085580
Disease: Essential Hypertension
Essential Hypertension 		0.320 GeneticVariation disease BEFREE Thus, we assessed the relationship between RGS5 genetic polymorphisms and essential hypertension (EH) in Chinese. 19863299 2009
CUI: C0030521
Disease: Parathyroid Neoplasms
Parathyroid Neoplasms 		0.020 AlteredExpression group BEFREE Regulator of G protein signaling 5 is highly expressed in parathyroid tumors and inhibits signaling by the calcium-sensing receptor. 21393447 2011
CUI: C0262587
Disease: Parathyroid Adenoma
Parathyroid Adenoma 		0.010 AlteredExpression disease BEFREE We confirmed RGS5 to be highly expressed in parathyroid adenomas relative to matched-pair normal glands. 21393447 2011