RGS5, regulator of G protein signaling 5, 8490

N. diseases: 52; N. variants: 5
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0085580
Disease: Essential Hypertension
Essential Hypertension 		0.320 Biomarker disease CTD_human
CUI: C0030521
Disease: Parathyroid Neoplasms
Parathyroid Neoplasms 		0.020 AlteredExpression group BEFREE Regulator of G protein signaling 5 is highly expressed in parathyroid tumors and inhibits signaling by the calcium-sensing receptor. 21393447 2011
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.050 Biomarker group BEFREE RGS5 expression by the cancer vasculature triggered and retained by the proangiogenic microenvironment supports its exploitation as a novel biomarker and opens the path to explore new possibilities of therapeutic intervention aimed at targeting tumor blood vessels. 22130514 2012
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.040 Biomarker group BEFREE RGS5 expression by the cancer vasculature triggered and retained by the proangiogenic microenvironment supports its exploitation as a novel biomarker and opens the path to explore new possibilities of therapeutic intervention aimed at targeting tumor blood vessels. 22130514 2012
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.060 Biomarker group BEFREE RGS5 expression by the cancer vasculature triggered and retained by the proangiogenic microenvironment supports its exploitation as a novel biomarker and opens the path to explore new possibilities of therapeutic intervention aimed at targeting tumor blood vessels. 22130514 2012
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.020 Biomarker phenotype BEFREE Regulator of G protein signaling 5 (RGS5) belongs to the R4 subfamily of RGS proteins, a family of GTPase activating proteins, which is dynamically regulated in various biological processes including blood pressure regulation, smooth muscle cell pathology, fat metabolism and tumor angiogenesis. 25891540 2015
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.010 Biomarker phenotype BEFREE Regulator of G-protein signaling 5 enhances portal vein invasion in hepatocellular carcinoma. 29434872 2018
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma 		0.020 AlteredExpression disease BEFREE RGS5 was highly expressed in the cytoplasm of ovarian carcinoma cells and in microvascular structures. 30365142 2019
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.020 AlteredExpression disease BEFREE RGS5 was highly expressed in the cytoplasm of ovarian carcinoma cells and in microvascular structures. 30365142 2019
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.550 Therapeutic group RGD Antihypertensive effects of peroxisome proliferator-activated receptor-β activation in spontaneously hypertensive rats. 21825230 2011
CUI: C0085580
Disease: Essential Hypertension
Essential Hypertension 		0.320 GeneticVariation disease BEFREE Association of regulator of G protein signaling (RGS5) gene variants and essential hypertension in Mongolian and Han populations. 26782409 2015
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.010 Biomarker disease BEFREE Collectively, our data indicated that RGS5 is crucial for the occurrence and development of ovarian cancer, and that RGS5 and its signaling pathway may serve as anti‑angiogenesis targets for the treatment of ovarian cancer. 30365142 2019
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.020 AlteredExpression phenotype BEFREE Elevated levels of RGS-5 in pericytes are also observed during wound healing and ovulation indicating a strong correlation between RGS-5 expression and active vessel remodeling beyond tumor angiogenesis. 15459006 2005
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.020 Biomarker disease LHGDN Expression profiling identifies smooth muscle cell diversity within human intima and plaque fibrous cap: loss of RGS5 distinguishes the cap. 16293795 2006
CUI: C0035412
Disease: Rhabdomyosarcoma
Rhabdomyosarcoma 		0.010 Biomarker disease BEFREE Finally, we show that the inflammatory genes Ccl11 and Rgs5 are involved in RMS growth. 30650360 2019
CUI: C0220630
Disease: Adult Liver Carcinoma
Adult Liver Carcinoma 		0.010 AlteredExpression disease BEFREE Further analysis showed that the over-expression of RGS5 is associated with liver cancer recurrence, venous infiltration, and patients' poor survival. 23868206 2013
CUI: C0279000
Disease: Liver and Intrahepatic Biliary Tract Carcinoma
Liver and Intrahepatic Biliary Tract Carcinoma 		0.010 AlteredExpression disease BEFREE Further analysis showed that the over-expression of RGS5 is associated with liver cancer recurrence, venous infiltration, and patients' poor survival. 23868206 2013
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver 		0.010 AlteredExpression disease BEFREE Further analysis showed that the over-expression of RGS5 is associated with liver cancer recurrence, venous infiltration, and patients' poor survival. 23868206 2013
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.030 AlteredExpression phenotype BEFREE Furthermore, high expression of RGS5 in cancerous tissue was significantly associated with PVI and tended to be associated with intrahepatic metastasis. 29434872 2018
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma 		0.020 Biomarker disease BEFREE Genes of regulator of G-protein signaling 5 in neuroblastoma cells and CHC1-L in lymphocytes increased after exposure to hydrostatic pressure. 14504426 2003
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma 		0.020 Biomarker disease BEFREE Genes of regulator of G-protein signaling 5 in neuroblastoma cells and CHC1-L in lymphocytes increased after exposure to hydrostatic pressure. 14504426 2003
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma 		0.020 Biomarker disease BEFREE Genes of regulator of G-protein signaling 5 in neuroblastoma cells and CHC1-L in lymphocytes increased after exposure to hydrostatic pressure. 14504426 2003
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases 		0.010 GeneticVariation group BEFREE Genetic variants of the RGS5 gene are believed to be risk factors for hypertension and cardiovascular diseases. 26782409 2015
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.550 AlteredExpression group BEFREE Here, we investigated the influence of regulator of G protein signaling 5 (RGS5), an inhibitor of Gα<sub>q/11</sub> and Gα<sub>i/o</sub> activity, on blood pressure and the VSMC phenotype during experimental hypertension. 29208700 2018
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.020 Biomarker phenotype BEFREE Identification of regulator of G protein signaling 5 (RGS5) as a key modulator of the vascular barrier in tumor progression and regression has brought new insights into the molecular basis of vessel normalization and opens new therapeutic opportunities. 18719382 2008