|
Amyotrophic Lateral Sclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Trimmed PE reads were aligned against the hg38 human transcriptome using Tophat2/Bowtie2 (ALS) or HISAT2 (AD and PD) and quantitated with Cufflinks.
|
30983949 |
2019 |
|
Hepatitis B
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found that LGR-5 expression was higher in tumor tissues than in normal liver tissues, and that high LGR-5 expression possibly favored poor outcomes in HCC, especially in well/moderate differentiation grade, hepatitis C virus (HCV)-negative, and hepatitis B virus (HBV)-positive groups.
|
31126119 |
2019 |
|
Liver diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
LGR5 is predominant in peri-septal hepatocytes rather than epithelial cell adhesion molecule (EpCAM) positive ductular reactions in chronic pediatric liver diseases and may represent a transitional HPC phenotype for the hepatocyte lineage.
|
28276299 |
2019 |
|
Meningioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, LGR5 and its downstream signaling play critical roles in neuroblastoma and brain tumors such as meningioma and pituitary adenoma.
|
31698554 |
2019 |
|
Parkinson Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Trimmed PE reads were aligned against the hg38 human transcriptome using Tophat2/Bowtie2 (ALS) or HISAT2 (AD and PD) and quantitated with Cufflinks.
|
30983949 |
2019 |
|
Pituitary Adenoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
LGR5 and Downstream Intracellular Signaling Proteins Play Critical Roles in the Cell Proliferation of Neuroblastoma, Meningioma and Pituitary Adenoma.
|
31698554 |
2019 |
|
Septicemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
The number of Lgr5-positive cells, the proliferation and apoptotic indices, several biomarkers for proliferation and differentiation, and Akt expression in intestinal stem cells were detected in vivo, in vitro and in two intestinal epithelial injury models caused by radiotherapy and sepsis.
|
30553965 |
2019 |
|
Stomatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Oral mucositis (OM) was induced by IR of the oral region of <i>Lgr5-lacZ</i> transgenic mice.
|
31497199 |
2019 |
|
Mucosal ulcer
|
0.010 |
Biomarker
|
disease |
BEFREE |
The surviving <i>Lgr5+</i> taste bud stem cells were identified after lacZ-staining and the mucosal ulceration on tongue dorsal surface was determined by histological methods.
|
31497199 |
2019 |
|
Sepsis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The number of Lgr5-positive cells, the proliferation and apoptotic indices, several biomarkers for proliferation and differentiation, and Akt expression in intestinal stem cells were detected in vivo, in vitro and in two intestinal epithelial injury models caused by radiotherapy and sepsis.
|
30553965 |
2019 |
|
Inflammatory Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Patients data (including clinical, demography, follow-up) were collected.Levels of UBE2C, LGR5, VM, and microvessel density (MVD) were significantly higher, and level of WWOX was significantly lower in IBC specimens when compared with normal mammary gland tissues.
|
31008954 |
2019 |
|
Adult Meningioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, LGR5 and its downstream signaling play critical roles in neuroblastoma and brain tumors such as meningioma and pituitary adenoma.
|
31698554 |
2019 |
|
Cancer Relapse
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Using patient-derived CRC organoids, we show that MEK inhibition leads to increased Wnt activity, elevated LGR5 levels and enrichment of gene signatures associated with stemness and cancer relapse.
|
31097693 |
2019 |
|
Invasive carcinoma of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, the clinicopathological significance of UBE2C, LGR5, WWOX, and VM in invasive breast carcinoma (IBC) remains elusive.
|
31008954 |
2019 |
|
Mild cognitive disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Differential Methylation in <i>APOE</i> (Chr19; Exon Four; from 44,909,188 to 44,909,373/hg38) and Increased Apolipoprotein E Plasma Levels in Subjects with Mild Cognitive Impairment.
|
30897703 |
2019 |
|
Skin Carcinogenesis
|
0.010 |
Biomarker
|
disease |
BEFREE |
<b>Methods</b>: We established experiments with wildtype and <i>Lgr5-CreER; Pten<sup>flox/flox</sup></i> mice, and used DMBA/TPA two-stage skin carcinogenesis model to explore the effect of <i>Pten</i> loss in Lgr5<sup>+</sup> HFSCs of 3 weeks old mice in skin carcinogenesis.
|
31754399 |
2019 |
|
Oral Mucositis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Oral mucositis (OM) was induced by IR of the oral region of <i>Lgr5-lacZ</i> transgenic mice.
|
31497199 |
2019 |
|
Meningioma, benign, no ICD-O subtype
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, LGR5 and its downstream signaling play critical roles in neuroblastoma and brain tumors such as meningioma and pituitary adenoma.
|
31698554 |
2019 |
|
Adrenal Cortex Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Co-expression analysis of stem cell (OCT4, SSEA4) and CSC (ALDH1/2, CD44 and LGR5) markers with proliferation marker (KI67) in HG tumors revealed dual positive proliferating stem and CSCs, few non-proliferating stem/CSC (SSEA4<sup>+</sup>/KI67<sup>-</sup> and ALDH1/2<sup>+</sup>/KI67<sup>-</sup>) and only KI67<sup>+</sup> cells in cortex, signifying dynamic populations and interesting cellular hierarchy in cortex region.
|
30121075 |
2018 |
|
Severe Combined Immunodeficiency
|
0.010 |
Biomarker
|
disease |
BEFREE |
FISH of TEI from male LGR5-EGFP enteroids implanted into female nonobese diabetic/severe combined immunodeficiency mice revealed that only the epithelium was Y chromosome positive.
|
29433868 |
2018 |
|
Neuroendocrine Tumors
|
0.010 |
AlteredExpression
|
group |
BEFREE |
We examined LGR5 expression using an RNAscope, a newly developed RNA in situ hybridization technique, with a tissue microarray of the neuroendocrine neoplasm samples.
|
30043418 |
2018 |
|
cortex bone disorders
|
0.010 |
Biomarker
|
disease |
BEFREE |
Co-expression analysis of stem cell (OCT4, SSEA4) and CSC (ALDH1/2, CD44 and LGR5) markers with proliferation marker (KI67) in HG tumors revealed dual positive proliferating stem and CSCs, few non-proliferating stem/CSC (SSEA4<sup>+</sup>/KI67<sup>-</sup> and ALDH1/2<sup>+</sup>/KI67<sup>-</sup>) and only KI67<sup>+</sup> cells in cortex, signifying dynamic populations and interesting cellular hierarchy in cortex region.
|
30121075 |
2018 |
|
Epithelial ovarian cancer
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The results demonstrated that LGR5 was overexpressed in EOC tissues and cell lines.
|
29777575 |
2018 |
|
ovarian neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
LGR5 and LGR6 in stem cell biology and ovarian cancer.
|
29416699 |
2018 |
|
precancerous lesions
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Effects of Celastrus orbiculatus on Epithelial Mesenchymal Transition in Gastric Mucosal Epithelial Cells by Inhibiting Lgr5 Expression from Rats with Gastric Precancerous Lesions.
|
29976080 |
2018 |