|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
<b>Background:</b> The leucine-rich repeat containing G protein-coupled receptor 5 (Lgr5) is considered a cancer stem cell marker, and is often overexpressed in tumors.
|
31417548 |
2019 |
|
Primary malignant neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
<b>Background:</b> The leucine-rich repeat containing G protein-coupled receptor 5 (Lgr5) is considered a cancer stem cell marker, and is often overexpressed in tumors.
|
31417548 |
2019 |
|
Skin Carcinogenesis
|
0.010 |
Biomarker
|
disease |
BEFREE |
<b>Methods</b>: We established experiments with wildtype and <i>Lgr5-CreER; Pten<sup>flox/flox</sup></i> mice, and used DMBA/TPA two-stage skin carcinogenesis model to explore the effect of <i>Pten</i> loss in Lgr5<sup>+</sup> HFSCs of 3 weeks old mice in skin carcinogenesis.
|
31754399 |
2019 |
|
Malignant neoplasm of stomach
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
<b>Results:</b> In this study, an immunosuppressive microenvironment was associated with high Lgr5 expression in GC.
|
31417548 |
2019 |
|
Stomach Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
<b>Results:</b> In this study, an immunosuppressive microenvironment was associated with high Lgr5 expression in GC.
|
31417548 |
2019 |
|
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
|
0.010 |
Biomarker
|
disease |
BEFREE |
Helicobacter pylori Activates and Expands Lgr5(+) Stem Cells Through Direct Colonization of the Gastric Glands.
|
25725293 |
2015 |
|
Stomatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Oral mucositis (OM) was induced by IR of the oral region of <i>Lgr5-lacZ</i> transgenic mice.
|
31497199 |
2019 |
|
Oral Mucositis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Oral mucositis (OM) was induced by IR of the oral region of <i>Lgr5-lacZ</i> transgenic mice.
|
31497199 |
2019 |
|
Colorectal Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
LGR5 expression showed marked variation among CRC cases and correlated significantly with lymphatic invasion, vascular invasion, tumor depth, lymph node metastasis, and tumor stage (IIIC vs. IIIB).
|
20384634 |
2010 |
|
Tumor Cell Invasion
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
LGR5 expression showed marked variation among CRC cases and correlated significantly with lymphatic invasion, vascular invasion, tumor depth, lymph node metastasis, and tumor stage (IIIC vs. IIIB).
|
20384634 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
LGR5 expression showed marked variation among CRC cases and correlated significantly with lymphatic invasion, vascular invasion, tumor depth, lymph node metastasis, and tumor stage (IIIC vs. IIIB).
|
20384634 |
2010 |
|
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
LGR5 expression was investigated by immunohistochemical analysis in 17 low-grade and 13 high-grade intraepithelial neoplasias and 30 adenocarcinomas.
|
21273608 |
2011 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
LGR5 expression in luminal surface showed a negative association with the progressive grade of tumors, while that in lower crypt exhibited a positive association with grade.
|
21273608 |
2011 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
LgR5 expression and cancer stem cell hypothesis: clue to define the true origin of esophageal adenocarcinomas with and without Barrett's esophagus?
|
21345220 |
2011 |
|
Primary malignant neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
LgR5 expression and cancer stem cell hypothesis: clue to define the true origin of esophageal adenocarcinomas with and without Barrett's esophagus?
|
21345220 |
2011 |
|
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
LgR5 expression and cancer stem cell hypothesis: clue to define the true origin of esophageal adenocarcinomas with and without Barrett's esophagus?
|
21345220 |
2011 |
|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
LGR5 correlated with metastasis, R2 resections and high-grade.
|
22605983 |
2012 |
|
Brain Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
LGR5 is a marker of poor prognosis in glioblastoma and is required for survival of brain cancer stem-like cells.
|
22805276 |
2013 |
|
Malignant neoplasm of brain
|
0.020 |
Biomarker
|
disease |
BEFREE |
LGR5 is a marker of poor prognosis in glioblastoma and is required for survival of brain cancer stem-like cells.
|
22805276 |
2013 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
LGR5 is overexpressed in some types of human cancer, and is one of the target genes of the Wnt signaling pathway.
|
23127514 |
2013 |
|
Primary malignant neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
LGR5 is overexpressed in some types of human cancer, and is one of the target genes of the Wnt signaling pathway.
|
23127514 |
2013 |
|
Immunologic Deficiency Syndromes
|
0.010 |
Biomarker
|
group |
BEFREE |
LGR5-transfected cells formed nodule type tumors in the livers of immunodeficient mice, whereas empty vector-transfected cells formed more invasive tumors.
|
23127514 |
2013 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Lgr5 expression as stem cell marker in human gastric gland and its relatedness with other putative cancer stem cell markers.
|
23664892 |
2013 |
|
Primary malignant neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Lgr5 expression as stem cell marker in human gastric gland and its relatedness with other putative cancer stem cell markers.
|
23664892 |
2013 |
|
Glioma
|
0.040 |
Biomarker
|
disease |
BEFREE |
LGR5 is a proneural factor and is regulated by OLIG2 in glioma stem-like cells.
|
23793848 |
2013 |