|
Primary malignant neoplasm
|
0.050 |
AlteredExpression
|
group |
BEFREE |
In addition, cyclin A2 expression is associated with a poor prognosis in several types of cancer.
|
14510182 |
2003 |
|
leukemia
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Leukemias with a -5/del(5q) have a higher expression of genes involved in cell cycle control (CCNA2, CCNE2, CDC2), checkpoints (BUB1), or growth (MYC), and loss of expression of the gene encoding interferon consensus sequence-binding protein (ICSBP).
|
15935816 |
2005 |
|
Mammary Neoplasms
|
0.030 |
AlteredExpression
|
group |
LHGDN |
Reliability of cyclin A assessment on tissue microarrays in breast cancer compared to conventional histological slides.
|
16670718 |
2006 |
|
Stomach Neoplasms
|
0.010 |
AlteredExpression
|
group |
LHGDN |
Prognostic significance of cyclin A in gastric cancer.
|
16708383 |
2006 |
|
Malignant Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
This analysis predicts that cancer cells manifesting a stem cell-like expression profile of a death-from-cancer signature would exhibit the following features: a concomitantly increased expression of certain members of inhibitor of apoptosis protein (IAP) family (Survivin and XIAP); activation of mitotic spindle check point proteins (BUB1, BUB3, KNTC2, Mad2, PLK1, PLK4, STK6/Aurora A); and elevated levels of certain cell cycle control/marker proteins (CCNB1, CCNB2, CCND1, CCNA2, CDC2, CDC25, Ki67, USP22).
|
16760651 |
2006 |
|
Primary malignant neoplasm
|
0.050 |
AlteredExpression
|
group |
BEFREE |
This analysis predicts that cancer cells manifesting a stem cell-like expression profile of a death-from-cancer signature would exhibit the following features: a concomitantly increased expression of certain members of inhibitor of apoptosis protein (IAP) family (Survivin and XIAP); activation of mitotic spindle check point proteins (BUB1, BUB3, KNTC2, Mad2, PLK1, PLK4, STK6/Aurora A); and elevated levels of certain cell cycle control/marker proteins (CCNB1, CCNB2, CCND1, CCNA2, CDC2, CDC25, Ki67, USP22).
|
16760651 |
2006 |
|
Mammary Neoplasms
|
0.030 |
AlteredExpression
|
group |
LHGDN |
Of the 80-breast tumour samples available for cyclin A gene amplification analyses, 26.7% (23/80) was defined to have cyclin A gene amplification.
|
16823179 |
2006 |
|
Mammary Neoplasms
|
0.030 |
GeneticVariation
|
group |
BEFREE |
Of the 80-breast tumour samples available for cyclin A gene amplification analyses, 26.7% (23/80) was defined to have cyclin A gene amplification.
|
16823179 |
2006 |
|
Adenocarcinoma
|
0.010 |
Biomarker
|
group |
LHGDN |
Cyclin A immunocytology as a risk stratification tool for Barrett's esophagus surveillance.
|
17255290 |
2007 |
|
Barrett Esophagus
|
0.010 |
Biomarker
|
disease |
LHGDN |
Cyclin A immunocytology as a risk stratification tool for Barrett's esophagus surveillance.
|
17255290 |
2007 |
|
Ganglioglioma
|
0.010 |
GeneticVariation
|
disease |
LHGDN |
Mutational and expression analysis of CDK1, cyclinA2 and cyclinB1 in epilepsy-associated glioneuronal lesions.
|
17359356 |
2007 |
|
Malformations of Cortical Development
|
0.010 |
GeneticVariation
|
disease |
LHGDN |
Mutational and expression analysis of CDK1, cyclinA2 and cyclinB1 in epilepsy-associated glioneuronal lesions.
|
17359356 |
2007 |
|
Vulval intraepithelial neoplasia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
By analyzing the biological processes affected by the observed differences, we found that VIN appears to be a highly proliferative disease; many cyclins (CCNA, CCNB and CCNE) and almost all prereplication complex proteins are upregulated.
|
17471573 |
2007 |
|
Mixed Salivary Gland Tumor
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
Cyclin A expression and its diagnostic value in pleomorphic adenoma and carcinoma expleomorphic adenoma of the parotid gland.
|
17593077 |
2007 |
|
Schizophrenia
|
0.300 |
Biomarker
|
disease |
PSYGENET |
Effects of schizophrenomimetics on the expression of the CCN1 (CYR 61) gene encoding a matricellular protein in the infant and adult neocortex of the mouse and rat.
|
17608974 |
2007 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
Expression of cyclin A in childhood acute lymphoblastic leukemia cells reveals undisturbed G1-S phase transition and passage through the S phase.
|
18668132 |
2009 |
|
Giant Cell Tumors
|
0.010 |
Biomarker
|
group |
LHGDN |
Immunohistochemical and biogenetic features of diffuse-type tenosynovial giant cell tumors: the potential roles of cyclin A, P53, and deletion of 15q in sarcomatous transformation.
|
18829481 |
2008 |
|
Idiopathic Pulmonary Fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results indicate that IPF-AEx is characterized by enhanced epithelial injury and proliferation, as reflected by increases in CCNA2 and alpha-defensins and apoptosis of epithelium.
|
19363140 |
2009 |
|
Malignant Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Although overexpression of cyclin A2 is reportedly an indicator of a poor prognosis of various malignancies including endometrial carcinoma, its molecular mechanism remains undetermined.
|
19583808 |
2010 |
|
Endometrial Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The expression of cyclin A2 protein was increased in advanced-stage and chemotherapy-refractory stage endometrial carcinomas compared with that in early-stage tumours.
|
19583808 |
2010 |
|
leukemia
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Here we show that transcription corepressor CtBP2 directly binds acinus, which is regulated by nerve growth factor (NGF), inhibiting its stimulatory effect on cyclin A1, but not cyclin A2, expression in leukemia.
|
19668232 |
2009 |
|
Childhood Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here we show that transcription corepressor CtBP2 directly binds acinus, which is regulated by nerve growth factor (NGF), inhibiting its stimulatory effect on cyclin A1, but not cyclin A2, expression in leukemia.
|
19668232 |
2009 |
|
Diabetes Mellitus, Experimental
|
0.200 |
Biomarker
|
disease |
RGD |
Significance of insulin signaling in liver regeneration triggered by portal vein ligation.
|
20031167 |
2011 |
|
Carcinogenesis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Upregulated genes in chemoresistant tumors included cell cycle regulating genes (TOP2A, BCAT1, CDCA8, CCNA2, CENPE), and genes with previously known mechanisms in tumorigenesis (S100A9, APOA1, RNF125, IFI16).
|
20066894 |
2009 |
|
Invasive carcinoma of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study investigated correlations of cyclin A2 and HER2 levels with clinical outcomes in 281 patients with invasive breast cancer in order to identify whether cyclin A2 can serve as a prognostic factor in HER2 negative patients.
|
20193482 |
2010 |