Liver Cirrhosis
|
0.310 |
Biomarker
|
disease |
CTD_human |
Characterization of chemically induced liver injuries using gene co-expression modules.
|
25226513 |
2014 |
Liver Cirrhosis
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
We used enzyme-linked immunosorbent assay (ELISA) to analytically validate serum levels of SMP30 and anti-SMP30 antibody in 143 patients with hepatocellular carcinoma (HCC), compared with those levels in serum from 137 patients with chronic hepatitis (CH), 51 with liver cirrhosis (LC), and 165 healthy control individuals.
|
29562243 |
2018 |
Hepatitis, Toxic
|
0.300 |
Biomarker
|
disease |
CTD_human |
Characterization of chemically induced liver injuries using gene co-expression modules.
|
25226513 |
2014 |
Hepatoma, Morris
|
0.300 |
Biomarker
|
disease |
CTD_human |
Expression profiling and identification of novel genes in hepatocellular carcinomas.
|
11420682 |
2001 |
Hepatoma, Novikoff
|
0.300 |
Biomarker
|
disease |
CTD_human |
Expression profiling and identification of novel genes in hepatocellular carcinomas.
|
11420682 |
2001 |
Liver Cirrhosis, Experimental
|
0.300 |
Biomarker
|
disease |
CTD_human |
Systems level analysis and identification of pathways and networks associated with liver fibrosis.
|
25380136 |
2014 |
Liver Cirrhosis, Experimental
|
0.300 |
Biomarker
|
disease |
CTD_human |
Gene expression profiles of hepatic cell-type specific marker genes in progression of liver fibrosis.
|
17072980 |
2006 |
Experimental Hepatoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Expression profiling and identification of novel genes in hepatocellular carcinomas.
|
11420682 |
2001 |
Fibrosis, Liver
|
0.300 |
Biomarker
|
disease |
CTD_human |
Characterization of chemically induced liver injuries using gene co-expression modules.
|
25226513 |
2014 |
Hepatitis, Drug-Induced
|
0.300 |
Biomarker
|
disease |
CTD_human |
Characterization of chemically induced liver injuries using gene co-expression modules.
|
25226513 |
2014 |
Drug-Induced Acute Liver Injury
|
0.300 |
Biomarker
|
disease |
CTD_human |
Characterization of chemically induced liver injuries using gene co-expression modules.
|
25226513 |
2014 |
Chemical and Drug Induced Liver Injury
|
0.300 |
Biomarker
|
disease |
CTD_human |
Characterization of chemically induced liver injuries using gene co-expression modules.
|
25226513 |
2014 |
Chemically-Induced Liver Toxicity
|
0.300 |
Biomarker
|
disease |
CTD_human |
Characterization of chemically induced liver injuries using gene co-expression modules.
|
25226513 |
2014 |
Liver carcinoma
|
0.290 |
AlteredExpression
|
disease |
BEFREE |
Serum antibody to SMP30 was tested by ELISA method; SMP30 mRNA and protein expression in HCC patients were analyzed using the methods of in situ nucleic acid hybridization and immunohistochemistry, respectively.
|
21047503 |
2011 |
Liver carcinoma
|
0.290 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of regucalcin may constitute a novel therapeutic approach to treating HCC.
|
27633001 |
2016 |
Liver carcinoma
|
0.290 |
Biomarker
|
disease |
BEFREE |
In this study we have cloned and characterized cDNA for regucalcin from human liver and human hepatoma cell line Hep G2 by screening and rapid amplification of cDNA ends (RACE).
|
10677570 |
2000 |
Liver carcinoma
|
0.290 |
Biomarker
|
disease |
BEFREE |
To clarify the functions of this SMP30/GNL, we transfected the human SMP30/GNL gene into the human liver carcinoma cell line, Hep G2.
|
19801822 |
2009 |
Liver carcinoma
|
0.290 |
AlteredExpression
|
disease |
BEFREE |
Regucalcin mRNA and protein expressions are also depressed in human hepatoma HepG2 cells, MCF-7 breast cancer cells, and prostate cancer LNCaP cells.
|
23692083 |
2013 |
Liver carcinoma
|
0.290 |
Biomarker
|
disease |
RGD |
In particular, increased levels of HSP70, HSP90, AKR1B1, AKR7A3, GCLM, ANXA5, VDBP, RGN and SULT1E1 were associated specifically with rat hepatomas, or with liver cancer progression in rat.
|
21683810 |
2011 |
Liver carcinoma
|
0.290 |
Biomarker
|
disease |
BEFREE |
Anti-SMP30 antibody levels can be used as a biomarker for diagnosing HCC; marked results have been observed for patients with alpha-fetoprotein (AFP) negativity, in particular.
|
29562243 |
2018 |
Liver carcinoma
|
0.290 |
AlteredExpression
|
disease |
BEFREE |
Moreover, the regucalcin gene and its protein levels were demonstrated specifically to downregulate in human hepatocellular carcinoma by analysis with multiple gene expression profiles and proteomics.
|
25230901 |
2015 |
Liver carcinoma
|
0.290 |
AlteredExpression
|
disease |
BEFREE |
Higher regucalcin expression has been demonstrated to prolong survival of the patients of pancreatic cancer, breast cancer, and hepatocellular carcinoma.
|
28181135 |
2017 |
Liver carcinoma
|
0.290 |
Biomarker
|
disease |
BEFREE |
Senescence marker protein 30 (SMP30), a hepatocellular carcinoma (HCC) associated antigen had been identified by our research group.
|
24606440 |
2014 |
Malignant neoplasm of liver
|
0.220 |
Biomarker
|
disease |
RGD |
In particular, increased levels of HSP70, HSP90, AKR1B1, AKR7A3, GCLM, ANXA5, VDBP, RGN and SULT1E1 were associated specifically with rat hepatomas, or with liver cancer progression in rat.
|
21683810 |
2011 |
Malignant neoplasm of liver
|
0.220 |
AlteredExpression
|
disease |
BEFREE |
A higher regucalcin expression in the tumor tissues has been demonstrated to prolong the survival of patients with various types of cancer, including pancreatic cancer, breast cancer, liver cancer and lung adenocarcinoma.
|
29956741 |
2018 |