|
Adenocarcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
A high expression of Survivin on the RNA level was negatively correlated with patients' survival in adenocarcinomas while a high Regucalcin expression was correlated positively.
|
31718698 |
2019 |
|
Non-Small Cell Lung Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These findings show that epigenetic re-programming of Survivin and Regucalcin in non-small cell lung cancer leads to enhanced expression of Survivin and reduced expression of Regucalcin, with a possible role of both molecules as predictive markers.
|
31718698 |
2019 |
|
Renal Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the involvement of regucalcin in human RCC.
|
30387835 |
2019 |
|
Hepatitis B
|
0.010 |
Biomarker
|
disease |
BEFREE |
We aimed to develop an enzyme-linked immunosorbent assay (ELISA) to quantify serum regucalcin in patients with hepatitis B virus (HBV)-related disease.
|
31576907 |
2019 |
|
Hypertensive disease
|
0.010 |
Biomarker
|
group |
BEFREE |
However, in hypoxic conditions, eNOS phosphorylation was reduced in both the WT and SMP30-deficient mice with no differences in Akt phosphorylation.Our study demonstrated that SMP30 is involved in the development of hypoxia-induced pulmonary hypertension by impairment of eNOS activity.
|
31735783 |
2019 |
|
Liver diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Serum regucalcin is a useful indicator of liver injury severity in patients with hepatitis B virus-related liver diseases.
|
31576907 |
2019 |
|
Rhabdomyosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Moreover, ZIKV Natal RGN SRIPs effectively self-replicated in rhabdomyosarcoma/muscle, glioblastoma/astrocytoma, and retinal pigmented epithelial cells, displaying unique cell susceptibility with differential attachment activity.
|
31683628 |
2019 |
|
Complete atrioventricular block
|
0.010 |
Biomarker
|
disease |
BEFREE |
The median serum regucalcin concentrations in HBV-ACLF and CHB patients were 5.46 and 3.76 ng/mL, respectively (P<0.01), which were much higher than in healthy controls (1.72 ng/mL, both P<0.01).
|
31576907 |
2019 |
|
Right Ventricular Hypertrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
The hypoxia-induced increases in right ventricular hypertrophy and medial smooth muscle area of the pulmonary artery were comparable between the WT and the SMP30-deficient mice.
|
31735783 |
2019 |
|
Childhood Rhabdomyosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Moreover, ZIKV Natal RGN SRIPs effectively self-replicated in rhabdomyosarcoma/muscle, glioblastoma/astrocytoma, and retinal pigmented epithelial cells, displaying unique cell susceptibility with differential attachment activity.
|
31683628 |
2019 |
|
Visceral Pain
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Dietary ascorbic acid restriction in GNL/SMP30-knockout mice unveils the role of ascorbic acid in regulation of somatic and visceral pain sensitivity.
|
30827506 |
2019 |
|
Argininosuccinic Aciduria
|
0.010 |
Biomarker
|
disease |
BEFREE |
We examined the effect of AsA deficiency on skeletal muscle using senescence marker protein-30 (SMP30)-knockout (KO) mice that are defective in AsA biosynthesis, which makes this mouse model similar to humans, to clarify the function of AsA in skeletal muscle.
|
30894591 |
2019 |
|
Adult Rhabdomyosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Moreover, ZIKV Natal RGN SRIPs effectively self-replicated in rhabdomyosarcoma/muscle, glioblastoma/astrocytoma, and retinal pigmented epithelial cells, displaying unique cell susceptibility with differential attachment activity.
|
31683628 |
2019 |
|
Cervical Adenocarcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
To understand the role of RGN in CA, RGN expression in human cervical cancer compared with normal tissues was analyzed using The Cancer Genome Atlas database (TCGA).
|
31289533 |
2019 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the involvement of regucalcin in human RCC.
|
30387835 |
2019 |
|
Neuropathy
|
0.010 |
Biomarker
|
group |
BEFREE |
The ascorbic acid restriction enhanced the somatic and visceral hypersensitivity following intraplantar and intracolonic NaHS, respectively, and paclitaxel-induced neuropathy in GNL/SMP30-knockout mice, while it had no such effect in wild-type mice.
|
30827506 |
2019 |
|
Hepatitis B, Chronic
|
0.010 |
Biomarker
|
disease |
BEFREE |
High-titer monoclonal antibodies and a polyclonal antibody to regucalcin were produced, a double-antibody sandwich ELISA method was established, and serum regucalcin was determined in 47 chronic hepatitis B (CHB) patients, 91 HBV-related acute-on-chronic liver failure (HBV-ACLF) patients, and 33 healthy controls.
|
31576907 |
2019 |
|
Malignant neoplasm of kidney
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Prolonged survival of renal cancer patients is concomitant with a higher regucalcin gene expression in tumor tissues: Overexpression of regucalcin suppresses the growth of human renal cell carcinoma cells in vitro.
|
30387835 |
2019 |
|
Renal carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Prolonged survival of renal cancer patients is concomitant with a higher regucalcin gene expression in tumor tissues: Overexpression of regucalcin suppresses the growth of human renal cell carcinoma cells in vitro.
|
30387835 |
2019 |
|
Coronary Artery Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Targeting AR-RGN or its top key driver PQBP1 may help reduce CAD side effects of these ART drugs.
|
31059280 |
2019 |
|
Clear-cell metastatic renal cell carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The prolonged survival of patients with clear cell RCC was demonstrated to be associated with a higher regucalcin gene expression in the TCGA dataset.
|
30387835 |
2019 |
|
Acute-On-Chronic Liver Failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
High-titer monoclonal antibodies and a polyclonal antibody to regucalcin were produced, a double-antibody sandwich ELISA method was established, and serum regucalcin was determined in 47 chronic hepatitis B (CHB) patients, 91 HBV-related acute-on-chronic liver failure (HBV-ACLF) patients, and 33 healthy controls.
|
31576907 |
2019 |
|
Immunosuppression
|
0.010 |
Biomarker
|
disease |
BEFREE |
High dietary vitamin C intake reduces glucocorticoid-induced immunosuppression and measures of oxidative stress in vitamin C-deficient senescence marker protein 30 knockout mice.
|
31647039 |
2019 |
|
Alzheimer's Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Thus, RGN possesses antioxidant activity against Aβ-induced oxidative and nitrosative stress and may play protective roles against Aβ-induced neurotoxicity in Alzheimer's disease.
|
29511612 |
2018 |
|
Ascorbic Acid Deficiency
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Transcriptome Analysis of Skin from SMP30/GNL Knockout Mice Reveals the Effect of Ascorbic Acid Deficiency on Skin and Hair.
|
28652426 |
2018 |