RGN, regucalcin, 9104

N. diseases: 96; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis 		0.310 AlteredExpression disease BEFREE We used enzyme-linked immunosorbent assay (ELISA) to analytically validate serum levels of SMP30 and anti-SMP30 antibody in 143 patients with hepatocellular carcinoma (HCC), compared with those levels in serum from 137 patients with chronic hepatitis (CH), 51 with liver cirrhosis (LC), and 165 healthy control individuals. 29562243 2018
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis 		0.310 Biomarker disease CTD_human Characterization of chemically induced liver injuries using gene co-expression modules. 25226513 2014
CUI: C0019193
Disease: Hepatitis, Toxic
Hepatitis, Toxic 		0.300 Biomarker disease CTD_human Characterization of chemically induced liver injuries using gene co-expression modules. 25226513 2014
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental 		0.300 Biomarker disease CTD_human Systems level analysis and identification of pathways and networks associated with liver fibrosis. 25380136 2014
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.300 Biomarker disease CTD_human Characterization of chemically induced liver injuries using gene co-expression modules. 25226513 2014
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease 		0.300 Biomarker phenotype CTD_human Characterization of chemically induced liver injuries using gene co-expression modules. 25226513 2014
CUI: C1262760
Disease: Hepatitis, Drug-Induced
Hepatitis, Drug-Induced 		0.300 Biomarker disease CTD_human Characterization of chemically induced liver injuries using gene co-expression modules. 25226513 2014
CUI: C3658290
Disease: Drug-Induced Acute Liver Injury
Drug-Induced Acute Liver Injury 		0.300 Biomarker disease CTD_human Characterization of chemically induced liver injuries using gene co-expression modules. 25226513 2014
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.300 Biomarker disease CTD_human Characterization of chemically induced liver injuries using gene co-expression modules. 25226513 2014
CUI: C4279912
Disease: Chemically-Induced Liver Toxicity
Chemically-Induced Liver Toxicity 		0.300 Biomarker disease CTD_human Characterization of chemically induced liver injuries using gene co-expression modules. 25226513 2014
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases 		0.300 Biomarker group CTD_human Regucalcin down-regulation in rat kidney tissue after treatment with nephrotoxicants. 18805471 2008
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental 		0.300 Biomarker disease CTD_human Gene expression profiles of hepatic cell-type specific marker genes in progression of liver fibrosis. 17072980 2006
CUI: C0019207
Disease: Hepatoma, Morris
Hepatoma, Morris 		0.300 Biomarker disease CTD_human Expression profiling and identification of novel genes in hepatocellular carcinomas. 11420682 2001
CUI: C0019208
Disease: Hepatoma, Novikoff
Hepatoma, Novikoff 		0.300 Biomarker disease CTD_human Expression profiling and identification of novel genes in hepatocellular carcinomas. 11420682 2001
CUI: C0023904
Disease: Liver Neoplasms, Experimental
Liver Neoplasms, Experimental 		0.300 Biomarker phenotype CTD_human Expression profiling and identification of novel genes in hepatocellular carcinomas. 11420682 2001
CUI: C0086404
Disease: Experimental Hepatoma
Experimental Hepatoma 		0.300 Biomarker disease CTD_human Expression profiling and identification of novel genes in hepatocellular carcinomas. 11420682 2001
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.290 Biomarker disease BEFREE Anti-SMP30 antibody levels can be used as a biomarker for diagnosing HCC; marked results have been observed for patients with alpha-fetoprotein (AFP) negativity, in particular. 29562243 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.290 AlteredExpression disease BEFREE Higher regucalcin expression has been demonstrated to prolong survival of the patients of pancreatic cancer, breast cancer, and hepatocellular carcinoma. 28181135 2017
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.290 AlteredExpression disease BEFREE Overexpression of regucalcin may constitute a novel therapeutic approach to treating HCC. 27633001 2016
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.290 AlteredExpression disease BEFREE Moreover, the regucalcin gene and its protein levels were demonstrated specifically to downregulate in human hepatocellular carcinoma by analysis with multiple gene expression profiles and proteomics. 25230901 2015
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.290 Biomarker disease BEFREE Senescence marker protein 30 (SMP30), a hepatocellular carcinoma (HCC) associated antigen had been identified by our research group. 24606440 2014
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.290 AlteredExpression disease BEFREE Regucalcin mRNA and protein expressions are also depressed in human hepatoma HepG2 cells, MCF-7 breast cancer cells, and prostate cancer LNCaP cells. 23692083 2013
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.290 AlteredExpression disease BEFREE Serum antibody to SMP30 was tested by ELISA method; SMP30 mRNA and protein expression in HCC patients were analyzed using the methods of in situ nucleic acid hybridization and immunohistochemistry, respectively. 21047503 2011
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.290 Biomarker disease RGD In particular, increased levels of HSP70, HSP90, AKR1B1, AKR7A3, GCLM, ANXA5, VDBP, RGN and SULT1E1 were associated specifically with rat hepatomas, or with liver cancer progression in rat. 21683810 2011
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.290 Biomarker disease BEFREE To clarify the functions of this SMP30/GNL, we transfected the human SMP30/GNL gene into the human liver carcinoma cell line, Hep G2. 19801822 2009