ASIC3, acid sensing ion channel subunit 3, 9311

N. diseases: 51; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030193
Disease: Pain
Pain
0.100 GeneticVariation phenotype BEFREE Several types of acid-sensing ion channels (ASIC1 and ASIC3) were associated with disturbed neurogenesis and melatonin-regulated pain mechanism. 31340682 2019
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.020 GeneticVariation group BEFREE To determine the association between ASIC3 genetic polymorphisms and insulin resistance in Taiwanese, 606 unrelated subjects with no history of cardiovascular disease were recruited during routine health examinations. 20416288 2010
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.020 GeneticVariation disease BEFREE In the ANDnet, we furthermore identified potential glioma suppressor genes ACCN3 and ACCN4 linked to the NBPF1 neuroblastoma breakpoint family, as well as numerous ABC transporter genes (ABCA1, ABCB1) suggesting drug resistance of glioblastoma tumors. 28019039 2017
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma
0.020 GeneticVariation disease BEFREE In the ANDnet, we furthermore identified potential glioma suppressor genes ACCN3 and ACCN4 linked to the NBPF1 neuroblastoma breakpoint family, as well as numerous ABC transporter genes (ABCA1, ABCB1) suggesting drug resistance of glioblastoma tumors. 28019039 2017
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma
0.020 GeneticVariation disease BEFREE In the ANDnet, we furthermore identified potential glioma suppressor genes ACCN3 and ACCN4 linked to the NBPF1 neuroblastoma breakpoint family, as well as numerous ABC transporter genes (ABCA1, ABCB1) suggesting drug resistance of glioblastoma tumors. 28019039 2017
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme
0.020 GeneticVariation disease BEFREE In the ANDnet, we furthermore identified potential glioma suppressor genes ACCN3 and ACCN4 linked to the NBPF1 neuroblastoma breakpoint family, as well as numerous ABC transporter genes (ABCA1, ABCB1) suggesting drug resistance of glioblastoma tumors. 28019039 2017
CUI: C0012833
Disease: Dizziness
Dizziness
0.010 GeneticVariation phenotype BEFREE However, whether the genetic variants of <i>ASIC3</i> are associated with people who suffer dizziness and balance impairment after mTBI remained unknown. 30804886 2019
CUI: C0017638
Disease: Glioma
Glioma
0.010 GeneticVariation disease BEFREE In the ANDnet, we furthermore identified potential glioma suppressor genes ACCN3 and ACCN4 linked to the NBPF1 neuroblastoma breakpoint family, as well as numerous ABC transporter genes (ABCA1, ABCB1) suggesting drug resistance of glioblastoma tumors. 28019039 2017
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.010 GeneticVariation disease BEFREE In the ANDnet, we furthermore identified potential glioma suppressor genes ACCN3 and ACCN4 linked to the NBPF1 neuroblastoma breakpoint family, as well as numerous ABC transporter genes (ABCA1, ABCB1) suggesting drug resistance of glioblastoma tumors. 28019039 2017
CUI: C0042571
Disease: Vertigo
Vertigo
0.010 GeneticVariation phenotype BEFREE However, whether the genetic variants of <i>ASIC3</i> are associated with people who suffer dizziness and balance impairment after mTBI remained unknown. 30804886 2019
CUI: C0575090
Disease: Equilibration disorder
Equilibration disorder
0.010 GeneticVariation phenotype BEFREE However, whether the genetic variants of <i>ASIC3</i> are associated with people who suffer dizziness and balance impairment after mTBI remained unknown. 30804886 2019
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma
0.010 GeneticVariation disease BEFREE In the ANDnet, we furthermore identified potential glioma suppressor genes ACCN3 and ACCN4 linked to the NBPF1 neuroblastoma breakpoint family, as well as numerous ABC transporter genes (ABCA1, ABCB1) suggesting drug resistance of glioblastoma tumors. 28019039 2017
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma
0.010 GeneticVariation disease BEFREE In the ANDnet, we furthermore identified potential glioma suppressor genes ACCN3 and ACCN4 linked to the NBPF1 neuroblastoma breakpoint family, as well as numerous ABC transporter genes (ABCA1, ABCB1) suggesting drug resistance of glioblastoma tumors. 28019039 2017
CUI: C0021368
Disease: Inflammation
Inflammation
0.300 Biomarker phenotype CTD_human Nonsteroid anti-inflammatory drugs inhibit both the activity and the inflammation-induced expression of acid-sensing ion channels in nociceptors. 11588175 2001
CUI: C0030193
Disease: Pain
Pain
0.100 Biomarker phenotype BEFREE ASIC3 quickly desensitizes in less than a second, limiting its capacity to sense sustained acidosis during pain. 30012583 2018
CUI: C0030193
Disease: Pain
Pain
0.100 Biomarker phenotype BEFREE Extracellular acidosis activates acid-sensing ion channel 3 (ASIC3) to trigger pain sensation. 28754162 2017
CUI: C0030193
Disease: Pain
Pain
0.100 Biomarker phenotype BEFREE Recent studies have indicated that ASIC3 in the peripheral trigeminal ganglia is likely involved in the pathogenesis of migraine pain. 30209688 2018
CUI: C0030193
Disease: Pain
Pain
0.100 Biomarker phenotype BEFREE Accordingly, a number of selective as well as nonselective ASIC3 inhibitors have shown potential in attenuating pain and inflammation in animal models of rheumatoid arthritis. 30035658 2018
CUI: C0030193
Disease: Pain
Pain
0.100 Biomarker phenotype BEFREE Acid-sensing ion channel 3 (ASIC3) plays a regulatory role in the pain pathway. 31734291 2020
CUI: C0030193
Disease: Pain
Pain
0.100 Biomarker phenotype BEFREE We used a mouse model of FM to determine if ASIC3 and its relevant signaling pathway participated in FM pain. 28440280 2017
CUI: C0030193
Disease: Pain
Pain
0.100 Biomarker phenotype BEFREE The ASIC3 subtype is found primarily in the periphery where the channel mediates pain signals caused by ischemia and inflammation. 28259560 2017
CUI: C0030193
Disease: Pain
Pain
0.100 Biomarker phenotype BEFREE ASIC3 might be a novel pharmacological target for pain after exercise. 31314951 2019
CUI: C0030193
Disease: Pain
Pain
0.100 Biomarker phenotype BEFREE Meanwhile, resveratrol also had an antinociceptive effect in ASIC3-mediated pain rat model. 29036449 2017
CUI: C0030193
Disease: Pain
Pain
0.100 Biomarker phenotype BEFREE The ASIC3 inhibitor, APETx2, increases the mechanical threshold of pain in models of knee osteoarthritis or postoperative pain. 27879566 2017
CUI: C0030193
Disease: Pain
Pain
0.100 Biomarker phenotype BEFREE The ASIC3 subunit has been shown to be of particular importance in the peripheral nervous system with pharmacological and genetic manipulations demonstrating a role in pain. 29237731 2018