|
Pain, Postoperative
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
This study aimed to explore the effect of remifentanil administration on postoperative pain and on ASIC3 expression at the prespinal and supraspinal levels in a rat model.
|
31734291 |
2020 |
|
Dizziness
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
However, whether the genetic variants of <i>ASIC3</i> are associated with people who suffer dizziness and balance impairment after mTBI remained unknown.
|
30804886 |
2019 |
|
Hypertensive disease
|
0.010 |
Biomarker
|
group |
BEFREE |
We tested the hypothesis that ASIC2 and ASIC3 contribute to increased pulmonary vasoreactivity and development of CH-induced pulmonary hypertension using ASIC2- and ASIC3-knockout (<sup>-/-</sup>) mice.
|
31169471 |
2019 |
|
Vertigo
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
However, whether the genetic variants of <i>ASIC3</i> are associated with people who suffer dizziness and balance impairment after mTBI remained unknown.
|
30804886 |
2019 |
|
Chronic pain
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Acid-sensing ion channels (ASICs) are extracellular proton-gated cation channels that have been implicated in multiple physiological and pathological processes, and peripheral ASIC3 prominently participate into the pathogenesis of chronic pain, itch, and neuroinflammation, which necessitates the need for discovery and development of novel modulators in a subtype-specific manner.
|
29781252 |
2019 |
|
Pain Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
ASIC3 is regulated by nerve growth factor (NGF), which induces hyperalgesia in various pain disorders.
|
30553789 |
2019 |
|
Equilibration disorder
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
However, whether the genetic variants of <i>ASIC3</i> are associated with people who suffer dizziness and balance impairment after mTBI remained unknown.
|
30804886 |
2019 |
|
Hyperalgesia, Thermal
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
CFA-induced hyperalgesia was accompanied by c-Fos up-regulation in DRG neurons, and the combination rescued thermal hyperalgesia through down-regulation of c-Fos and ASIC3 expression in CFA-induced inflammation.
|
30618119 |
2019 |
|
Ischemic stroke
|
0.010 |
Biomarker
|
disease |
BEFREE |
They have been implicated in a range of pathologies including ischemic stroke (ASIC1a subtype) and peripheral pain (ASIC1b and ASIC3).
|
30849303 |
2019 |
|
Seizures
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Taken together, our findings suggest that ASIC3 inhibition aggravates seizure and potentiates seizure induced hyperexcitability at least partly by the NMDAR/CaMKII/CREB signaling pathway, which implies that ASIC3 agonists may be a promising approach for seizure treatment.
|
29736613 |
2018 |
|
Oropharyngeal Dysphagia
|
0.010 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to assess the expression and localization of TRPM8, ASIC1, and ASIC3 in human samples of the oropharynx to lay the basis for new pharmacological treatments for OD.
|
29971861 |
2018 |
|
Oropharynx (excludes nasopharynx)
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study was to assess the expression and localization of TRPM8, ASIC1, and ASIC3 in human samples of the oropharynx to lay the basis for new pharmacological treatments for OD.
|
29971861 |
2018 |
|
Agnosia for Pain
|
0.010 |
Biomarker
|
disease |
BEFREE |
Role of ASIC3, Nav1.7 and Nav1.8 in electroacupuncture-induced analgesia in a mouse model of fibromyalgia pain.
|
29343477 |
2018 |
|
Coughing
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Receptors implicated in cough hypersensitivity are transient receptor potential vanilloid 1 (TRPV1), transient receptor potential cation channel, Subfamily A, Member 1 (TRPA1) and acid sensing ion channel receptor 3 (ASIC3).
|
28187208 |
2017 |
|
Glioma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In the ANDnet, we furthermore identified potential glioma suppressor genes ACCN3 and ACCN4 linked to the NBPF1 neuroblastoma breakpoint family, as well as numerous ABC transporter genes (ABCA1, ABCB1) suggesting drug resistance of glioblastoma tumors.
|
28019039 |
2017 |
|
Heartburn
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Inhibition of ASIC1 and ASIC3 with siRNA or pharmacological inhibitor significantly decreased [Ca<sup>2+</sup>]i and its downstream RhoA during acidity and, thus, suppressed acidity-induced epithelial-mesenchymal transition (EMT) of pancreatic cancer cells.
|
28518134 |
2017 |
|
Multiple Myeloma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, they present a mechanistic rationale for targeting ASIC3 on neurons along with the multiple myeloma-induced acidic bone microenvironment as a strategy to relieve MMBP in patients.<i></i>.
|
28254863 |
2017 |
|
Neuroblastoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In the ANDnet, we furthermore identified potential glioma suppressor genes ACCN3 and ACCN4 linked to the NBPF1 neuroblastoma breakpoint family, as well as numerous ABC transporter genes (ABCA1, ABCB1) suggesting drug resistance of glioblastoma tumors.
|
28019039 |
2017 |
|
Secondary malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Significantly, although without obvious effect on proliferation, knockdown of ASIC1 and ASIC3 in pancreatic cancer cells significantly suppresses liver and lung metastasis in xenograft model.
|
28518134 |
2017 |
|
Malignant Bone Neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Resveratrol attenuates bone cancer pain through regulating the expression levels of ASIC3 and activating cell autophagy.
|
29036449 |
2017 |
|
Prolapsed lumbar disc
|
0.010 |
Biomarker
|
disease |
BEFREE |
This ASIC3 channel inhibitor may be a potential therapeutic agent in early-stage lumbar disc herniation.
|
27879566 |
2017 |
|
Osteosarcoma of bone
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Resveratrol attenuates bone cancer pain through regulating the expression levels of ASIC3 and activating cell autophagy.
|
29036449 |
2017 |
|
Central neuroblastoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In the ANDnet, we furthermore identified potential glioma suppressor genes ACCN3 and ACCN4 linked to the NBPF1 neuroblastoma breakpoint family, as well as numerous ABC transporter genes (ABCA1, ABCB1) suggesting drug resistance of glioblastoma tumors.
|
28019039 |
2017 |
|
Childhood Neuroblastoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In the ANDnet, we furthermore identified potential glioma suppressor genes ACCN3 and ACCN4 linked to the NBPF1 neuroblastoma breakpoint family, as well as numerous ABC transporter genes (ABCA1, ABCB1) suggesting drug resistance of glioblastoma tumors.
|
28019039 |
2017 |
|
Coronary Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Recent studies demonstrate that acid-sensing ion channel 3 (ASIC3) is a sensitive acid sensor for cardiac ischemia and prolonged mild acidification can open ASIC3 and evoke a sustained inward current that fires action potentials in cardiac sensory neurons.
|
24804235 |
2014 |