ASIC3, acid sensing ion channel subunit 3, 9311

N. diseases: 51; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.020 GeneticVariation disease BEFREE In the ANDnet, we furthermore identified potential glioma suppressor genes ACCN3 and ACCN4 linked to the NBPF1 neuroblastoma breakpoint family, as well as numerous ABC transporter genes (ABCA1, ABCB1) suggesting drug resistance of glioblastoma tumors. 28019039 2017
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.020 AlteredExpression disease BEFREE Glioblastoma cancer stem cell lines express functional acid sensing ion channels ASIC1a and ASIC3. 29057936 2017
CUI: C0563625
Disease: Agnosia for Pain
Agnosia for Pain 		0.010 Biomarker disease BEFREE Role of ASIC3, Nav1.7 and Nav1.8 in electroacupuncture-induced analgesia in a mouse model of fibromyalgia pain. 29343477 2018
CUI: C0221106
Disease: Alkalemia
Alkalemia 		0.010 AlteredExpression disease BEFREE Acidic pH increased [Ca(2+)](i) and decreased p-ERK expression in WT FLS; these effects were significantly smaller in ASIC3-/- FLS and were prevented by blockade of [Ca(2+)]i. 24923411 2014
CUI: C0003864
Disease: Arthritis
Arthritis 		0.020 AlteredExpression disease BEFREE Acid-sensing ion channel 3 (ASIC3) is expressed in synoviocytes, activated by decreases in pH, and reduces inflammation in animal models of inflammatory arthritis. 24923411 2014
CUI: C0003864
Disease: Arthritis
Arthritis 		0.020 Biomarker disease BEFREE The present review discusses the dual nature of ASIC3 in joint inflammation with possible mechanisms. 30035658 2018
CUI: C0262385
Disease: Autonomic nervous system imbalance
Autonomic nervous system imbalance 		0.010 Biomarker disease BEFREE The acid-sensing ion channel 3 (ASIC3) is a ligand-gated cation channel activated by extracellular protons, and is associated with an exercise-induced pressor reflex and possibly autonomic imbalance. 18854755 2008
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases 		0.020 GeneticVariation group BEFREE To determine the association between ASIC3 genetic polymorphisms and insulin resistance in Taiwanese, 606 unrelated subjects with no history of cardiovascular disease were recruited during routine health examinations. 20416288 2010
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases 		0.020 Biomarker group BEFREE In summary, we unraveled an important role of ASIC3 in regulating cardiac autonomic function, whereby loss of ASIC3 alters the normal physiological response to ischemic stimuli, which reveals new implications for therapy in autonomic nervous system-related cardiovascular diseases. 24804235 2014
CUI: C0700095
Disease: Central neuroblastoma
Central neuroblastoma 		0.010 GeneticVariation disease BEFREE In the ANDnet, we furthermore identified potential glioma suppressor genes ACCN3 and ACCN4 linked to the NBPF1 neuroblastoma breakpoint family, as well as numerous ABC transporter genes (ABCA1, ABCB1) suggesting drug resistance of glioblastoma tumors. 28019039 2017
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.020 GeneticVariation disease BEFREE In the ANDnet, we furthermore identified potential glioma suppressor genes ACCN3 and ACCN4 linked to the NBPF1 neuroblastoma breakpoint family, as well as numerous ABC transporter genes (ABCA1, ABCB1) suggesting drug resistance of glioblastoma tumors. 28019039 2017
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.020 AlteredExpression disease BEFREE Glioblastoma cancer stem cell lines express functional acid sensing ion channels ASIC1a and ASIC3. 29057936 2017
CUI: C4086165
Disease: Childhood Neuroblastoma
Childhood Neuroblastoma 		0.010 GeneticVariation disease BEFREE In the ANDnet, we furthermore identified potential glioma suppressor genes ACCN3 and ACCN4 linked to the NBPF1 neuroblastoma breakpoint family, as well as numerous ABC transporter genes (ABCA1, ABCB1) suggesting drug resistance of glioblastoma tumors. 28019039 2017
CUI: C0015674
Disease: Chronic Fatigue Syndrome
Chronic Fatigue Syndrome 		0.010 Biomarker disease BEFREE Patients with CFS with comorbid fibromyalgia (n = 18) also showed greater increases in acid-sensing ion channel 3 and purinergic type 2X5 receptors (p < .05). 22210239 2012
CUI: C0150055
Disease: Chronic pain
Chronic pain 		0.010 Biomarker phenotype BEFREE Acid-sensing ion channels (ASICs) are extracellular proton-gated cation channels that have been implicated in multiple physiological and pathological processes, and peripheral ASIC3 prominently participate into the pathogenesis of chronic pain, itch, and neuroinflammation, which necessitates the need for discovery and development of novel modulators in a subtype-specific manner. 29781252 2019
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis 		0.010 Biomarker disease BEFREE Recent studies demonstrate that acid-sensing ion channel 3 (ASIC3) is a sensitive acid sensor for cardiac ischemia and prolonged mild acidification can open ASIC3 and evoke a sustained inward current that fires action potentials in cardiac sensory neurons. 24804235 2014
CUI: C0010200
Disease: Coughing
Coughing 		0.010 Biomarker phenotype BEFREE Receptors implicated in cough hypersensitivity are transient receptor potential vanilloid 1 (TRPV1), transient receptor potential cation channel, Subfamily A, Member 1 (TRPA1) and acid sensing ion channel receptor 3 (ASIC3). 28187208 2017
CUI: C0012833
Disease: Dizziness
Dizziness 		0.010 GeneticVariation phenotype BEFREE However, whether the genetic variants of <i>ASIC3</i> are associated with people who suffer dizziness and balance impairment after mTBI remained unknown. 30804886 2019
CUI: C0575090
Disease: Equilibration disorder
Equilibration disorder 		0.010 GeneticVariation phenotype BEFREE However, whether the genetic variants of <i>ASIC3</i> are associated with people who suffer dizziness and balance impairment after mTBI remained unknown. 30804886 2019
CUI: C0015672
Disease: Fatigue
Fatigue 		0.010 Biomarker phenotype BEFREE We recently demonstrated that acid sensing ion channel (probably ASIC3), purinergic type 2X receptors (probably P2X4 and P2X5) and the transient receptor potential vanilloid type 1 (TRPV1) are molecular receptors in mouse sensory neurons detecting metabolites that cause acute muscle pain and possibly muscle fatigue. 19647494 2009
CUI: C0016053
Disease: Fibromyalgia
Fibromyalgia 		0.040 AlteredExpression disease BEFREE Nociceptive receptors, such as ASIC3, Nav1.7, and Nav1.8, were upregulated in the dorsal root ganglion (DRG) and spinal cord (SC) of FM mice. 28440280 2017
CUI: C0016053
Disease: Fibromyalgia
Fibromyalgia 		0.040 Biomarker disease BEFREE Asic3<sup>-/-</sup> mice were impaired in only muscle allodynia development but not other pain symptoms in the ICS model, so the ASIC3-dependent metabolomics changes could be useful for developing diagnostic biomarkers specific to chronic widespread muscle pain, the core symptom of FM. 31431652 2019
CUI: C0016053
Disease: Fibromyalgia
Fibromyalgia 		0.040 AlteredExpression disease BEFREE ASIC3, Nav1.7 and Nav1.8 protein levels increased significantly in both the dorsal root ganglion and in the spinal cord of FM model mice. 29343477 2018
CUI: C0016053
Disease: Fibromyalgia
Fibromyalgia 		0.040 Biomarker disease BEFREE Patients with CFS with comorbid fibromyalgia (n = 18) also showed greater increases in acid-sensing ion channel 3 and purinergic type 2X5 receptors (p < .05). 22210239 2012
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.020 GeneticVariation disease BEFREE In the ANDnet, we furthermore identified potential glioma suppressor genes ACCN3 and ACCN4 linked to the NBPF1 neuroblastoma breakpoint family, as well as numerous ABC transporter genes (ABCA1, ABCB1) suggesting drug resistance of glioblastoma tumors. 28019039 2017