Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The genetic polymorphisms at the CDH13 locus independently affect the adiponectin levels, whereas the adiponectin levels exhibit a suppressive effect on the association between CDH13 locus variants and various metabolic phenotypes and metabolic syndrome.
|
25875811 |
2015 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this way, the present study aimed to analyze the possible association between the ADIPOQ + 45T> G gene polymorphism, usual diet and metabolic syndrome in the elderly.
|
29313754 |
2019 |
Metabolic Syndrome X
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Moreover, while men with MS exhibited an expected lower adiponectinemia, they displayed 2.1-fold higher adiponectin levels in SP than men without MS.
|
31705791 |
2020 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
CDH13 Polymorphisms are Associated with Adiponectin Levels and Metabolic Syndrome Traits Independently of Visceral Fat Mass.
|
26423718 |
2016 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Multivariable regression analysis revealed that BMI-Z-score >1.036 at time of evaluation was associated with 4.3-fold increased risk (P=.050) and adiponectin levels ≤6 μg/mL were associated with 6.7-fold increased risk of develop components of the MetS (P=.007).
|
28039914 |
2017 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A recent genome-wide scan study mapped a susceptibility locus for type 2 diabetes and the metabolic syndrome to chromosome 3q27, where the adiponectin gene is located.
|
12086969 |
2002 |
Metabolic Syndrome X
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A secondary aim was to analyse the associations of adiponectin plasma levels, as well as control and insulin-stimulated gene expression levels with different features of the metabolic syndrome.
|
18208577 |
2008 |
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
Adiponectin regulates glucose and lipid metabolism, acting against atherosclerosis and metabolic syndrome.
|
28606559 |
2017 |
Metabolic Syndrome X
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We aim to determine the serum adiponectin levels in Chinese patients with schizophrenia, and explore the relationship between adiponectin levels and metabolic parameters, including MetS and its components.
|
31059867 |
2019 |
Metabolic Syndrome X
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Central obesity and low levels of high-density lipoprotein cholesterol were positively associated with MetS and reduced serum adiponectin levels.
|
25074391 |
2015 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recently two adiponectin receptors were described and genetic variations in their genes were associated with features of the metabolic syndrome.
|
16678433 |
2006 |
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
Genetic and environmental factors influence serum adiponectin and may contribute to risk of metabolic syndrome and T2D.
|
19238139 |
2009 |
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
Adiponectin gene SNPs may have several phenotypic effects that co-occur with the development of the metabolic syndrome.
|
15047634 |
2004 |
Metabolic Syndrome X
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In both groups, adiponectin levels were inversely correlated with body fat mass (controls, r=-0.44, p=0.036; FDLP, r=-0.67, p=0.025), insulin resistance (controls, r=-0.62, p=0.003; FDLP, r=-0.70, p=0.025) and other features of the metabolic syndrome.
|
16320084 |
2005 |
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
Moreover, serum levels of some metabolic syndrome-related biomarkers, adipokines such as adiponectin and biomarkers of endothelial cell activation and inflammation such as Osteoprotegerin and Asymmetric dimethylarginine have recently been found useful for the prediction of CV disease in these patients.
|
27490206 |
2016 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
However, genetic variation in ADIPOQ and its receptors does not appear to contribute to the risk of insulin resistance or metabolic syndrome but did for type 2 diabetes in a European-Australian population.
|
23351195 |
2013 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We genotyped single-nucleotide polymorphisms (SNPs) in ADIPOQ, ADIPOR1 and ADIPOR2 in Mexican American subjects (N=439) and performed an association analysis of IRS-related traits.
|
16955209 |
2006 |
Metabolic Syndrome X
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Physical training increases circulating adiponectin and mRNA expression of its receptors in muscle, which may mediate the improvement of insulin resistance and the metabolic syndrome in response to exercise.
|
16551730 |
2006 |
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
Adiponectin (Ad) is reported to reduce insulin resistance in metabolic syndrome.
|
19533865 |
2008 |
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
The relationships between RBP4 levels, the established adipokines (leptin and adiponectin) and the components of MS were examined in 3445 school-aged children recruited in 2004 for the Beijing Child and Adolescent Metabolic Syndrome study.
|
29759068 |
2018 |
Metabolic Syndrome X
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Adiponectin levels were significantly higher in patients with lower BMI (<i>r</i> = -0.23; <i>p</i> < .0001) and in patients without metabolic syndrome compared to patients with higher BMI and with metabolic syndrome.
|
31179792 |
2019 |
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
The hormone, adiponectin (ApN), which is decreased in the metabolic syndrome, exhibits anti-inflammatory properties on skeletal muscle and alleviates the dystrophic phenotype of mdx mice.
|
28188344 |
2017 |
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
The hormone adiponectin is secreted by white adipocytes and has been put forward as a key mediator of obesity-linked insulin resistance and the metabolic syndrome.
|
31337827 |
2019 |
Metabolic Syndrome X
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Genetic variants of adiponectin receptor 2 are associated with increased adiponectin levels and decreased triglyceride/VLDL levels in patients with metabolic syndrome.
|
16700915 |
2006 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Reduced serum adiponectin levels have been found in obesity and type 2 diabetes and variations in the adiponectin gene (APM1) have been associated with type 2 diabetes and features of the metabolic syndrome in different populations.
|
16231017 |
2006 |