Metabolic Syndrome X
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
This regulation could contribute to the decreased apM1/ApN levels in insulin-resistant patients with obesity and the Metabolic Syndrome.
|
11700024 |
2001 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome.
|
11549668 |
2001 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A recent genome-wide scan study mapped a susceptibility locus for type 2 diabetes and the metabolic syndrome to chromosome 3q27, where the adiponectin gene is located.
|
12086969 |
2002 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We conclude that variability at the adiponectin locus is associated with obesity and other features of the insulin resistance syndrome, but given the nature of the two SNPs, the risk haplotype is most probably a marker in linkage disequilibrium with an as yet unidentified polymorphism that affects plasma adiponectin levels and insulin sensitivity.
|
12086965 |
2002 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide scans have mapped a susceptibility locus for type 2 diabetes and the metabolic syndrome to chromosome 3q27, where the adiponectin gene is located.
|
11756320 |
2002 |
Metabolic Syndrome X
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, circulating plasma adiponectin levels were decreased in nonobese but insulin-resistant FDR and, in addition, related to several facets of the insulin resistance syndrome (IRS).
|
12716750 |
2003 |
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
LHGDN |
The genetics of adiponectin.
|
12728641 |
2003 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These studies 1) definitively demonstrate the presence of severe peripheral and hepatic insulin resistance in the affected subjects; 2) describe a stereotyped pattern of partial lipodystrophy associated with all the features of the metabolic syndrome and nonalcoholic steatohepatitis; 3) document abnormalities in the in vivo function of remaining adipose tissue, including the inability of subcutaneous abdominal adipose tissue to trap and store free fatty acids postprandially and the presence of very low circulating levels of adiponectin; 4) document the presence of severe hyperinsulinemia in prepubertal carriers of the proline-467-leucine (P467L) PPAR-gamma mutation; 5) provide the first direct evidence of cellular resistance to PPAR-gamma agonists in mononuclear cells derived from the patients; and 6) report on the metabolic response to thiazolidinedione therapy in two affected subjects.
|
12663460 |
2003 |
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
Subjects with this mutation showed markedly low level of plasma adiponectin and clinical features of the metabolic syndrome.
|
12788102 |
2003 |
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
Adiponectin gene SNPs may have several phenotypic effects that co-occur with the development of the metabolic syndrome.
|
15047634 |
2004 |
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
Adiponectin is one of the key molecules in the metabolic syndrome, and its concentration is decreased in obesity, type-2 diabetes, and coronary artery disease.
|
15123570 |
2004 |
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
Adiponectin and metabolic syndrome.
|
14551151 |
2004 |
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
These data show adiponectin to be an important factor in the issue of obesity and its associated disorders, and indicate a potential future utilization of adiponectin as a drug in the treatment of metabolic syndrome.
|
15682645 |
2004 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The I164T mutation in the adiponectin gene was a common genetic background associated with the metabolic syndrome and CAD in the Japanese population.
|
15063429 |
2004 |
Metabolic Syndrome X
|
0.400 |
Biomarker
|
disease |
BEFREE |
The data suggest that adiponectin is related to the protection against the metabolic syndrome but is not involved in the regulation of VLCD-induced improvement of insulin sensitivity.
|
14764792 |
2004 |
Metabolic Syndrome X
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In both groups, adiponectin levels were inversely correlated with body fat mass (controls, r=-0.44, p=0.036; FDLP, r=-0.67, p=0.025), insulin resistance (controls, r=-0.62, p=0.003; FDLP, r=-0.70, p=0.025) and other features of the metabolic syndrome.
|
16320084 |
2005 |
Metabolic Syndrome X
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Also, adiponectin gene expression was significantly lower in women with vs. without the metabolic syndrome (adiponectin-beta-actin ratio, 2.26 +/- 0.46 vs. 3.31 +/- 0.33, P < 0.05).
|
15562250 |
2005 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Several genetic studies have observed evidence of association between APM1 gene polymorphisms and features of the metabolic syndrome, such as insulin resistance and obesity.
|
15843989 |
2005 |
Metabolic Syndrome X
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our findings indicate that serum adiponectin levels are associated with several components of the MS.
|
15919831 |
2005 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recently two adiponectin receptors were described and genetic variations in their genes were associated with features of the metabolic syndrome.
|
16678433 |
2006 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We genotyped single-nucleotide polymorphisms (SNPs) in ADIPOQ, ADIPOR1 and ADIPOR2 in Mexican American subjects (N=439) and performed an association analysis of IRS-related traits.
|
16955209 |
2006 |
Metabolic Syndrome X
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Physical training increases circulating adiponectin and mRNA expression of its receptors in muscle, which may mediate the improvement of insulin resistance and the metabolic syndrome in response to exercise.
|
16551730 |
2006 |
Metabolic Syndrome X
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Genetic variants of adiponectin receptor 2 are associated with increased adiponectin levels and decreased triglyceride/VLDL levels in patients with metabolic syndrome.
|
16700915 |
2006 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Reduced serum adiponectin levels have been found in obesity and type 2 diabetes and variations in the adiponectin gene (APM1) have been associated with type 2 diabetes and features of the metabolic syndrome in different populations.
|
16231017 |
2006 |
Metabolic Syndrome X
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genetic architecture of the APM1 gene and its influence on adiponectin plasma levels and parameters of the metabolic syndrome in 1,727 healthy Caucasians.
|
16443770 |
2006 |