|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Here, we provide a simple and rapid protocol for the generation of transgenic mice expressing Cre recombinase in a cell type-specific manner-in our example we chose cells expressing Ncr1, which encodes for the surface protein NKp46-and the use of those mice to ablate NKp46+ cells in order to study their role in a model of cancer immunosurveillance against experimental pulmonary metastases.
|
30465202 |
2019 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Here, we provide a simple and rapid protocol for the generation of transgenic mice expressing Cre recombinase in a cell type-specific manner-in our example we chose cells expressing Ncr1, which encodes for the surface protein NKp46-and the use of those mice to ablate NKp46+ cells in order to study their role in a model of cancer immunosurveillance against experimental pulmonary metastases.
|
30465202 |
2019 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Human anti-NKp46 antibody for studies of NKp46-dependent NK cell function and its applications for type 1 diabetes and cancer research.
|
30536875 |
2019 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Using several mouse tumor models, we demonstrate the importance of NK cells in protection from reovirus infection and in reovirus killing of tumors <i>in vivo</i> Collectively, we identify a new ligand for the NKp46 receptor and provide evidence for the importance of NKp46 in the control of reovirus infections and in reovirus-based cancer therapy.
|
28724773 |
2017 |
|
Malignant Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Natural-killer receptor group 2, member D (NKG2D) is a well characterized natural killer (NK) cell activating receptor that recognizes several ligands poorly expressed on healthy cells but up-regulated upon stressing stimuli in the context of cancer or viral infection.
|
28767057 |
2017 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Using several mouse tumor models, we demonstrate the importance of NK cells in protection from reovirus infection and in reovirus killing of tumors <i>in vivo</i> Collectively, we identify a new ligand for the NKp46 receptor and provide evidence for the importance of NKp46 in the control of reovirus infections and in reovirus-based cancer therapy.
|
28724773 |
2017 |
|
Primary malignant neoplasm
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Natural-killer receptor group 2, member D (NKG2D) is a well characterized natural killer (NK) cell activating receptor that recognizes several ligands poorly expressed on healthy cells but up-regulated upon stressing stimuli in the context of cancer or viral infection.
|
28767057 |
2017 |
|
Leukemia, Myelocytic, Acute
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, we validate the prognostic value of NKp46 expression at diagnosis in AML.
|
29209559 |
2017 |
|
Virus Diseases
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Domain 1-negative NKp46 splice variants (i.e., NKp46 isoform d) were the predominantly expressed isoform in nasal lavage following viral infections.
|
28261217 |
2017 |
|
Virus Diseases
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Natural-killer receptor group 2, member D (NKG2D) is a well characterized natural killer (NK) cell activating receptor that recognizes several ligands poorly expressed on healthy cells but up-regulated upon stressing stimuli in the context of cancer or viral infection.
|
28767057 |
2017 |
|
Hepatitis C
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The variation of the NKp46 proportion in individuals could be attributed to the diversity of HCV resistance observed in these individuals, which possibly reflects the clinical outcome of infection in patients.
|
26714120 |
2016 |
|
Hepatitis C
|
0.030 |
Biomarker
|
disease |
BEFREE |
Similarly, ligation of NKp46 on isolated NK cells resulted in a significant reduction in the HCV copy number detected in Huh-7.5/JFH-1 coculture (multiplicity of infection: 0.01) at an effector:target ratio of 5:1 (P < 0.005).
|
22505144 |
2012 |
|
Hepatitis C
|
0.030 |
Biomarker
|
disease |
BEFREE |
However, reports on NKp46 in hepatitis C are controversial.
|
22532190 |
2012 |
|
Leukemia, Myelocytic, Acute
|
0.030 |
Biomarker
|
disease |
BEFREE |
Our longitudinal study of AML patients showed that the NCR(dull) phenotype was acquired during leukemia development because we observed its complete (for NKp46) or partial (for NKp30) reversibility in patients achieving complete remission (CR).
|
16940427 |
2007 |
|
Virus Diseases
|
0.030 |
Biomarker
|
group |
BEFREE |
There was enhanced spread of certain tumors in 129/Sv but not C57BL/6 Ncr1(gfp/gfp) mice, and influenza virus infection was lethal in both 129/Sv and C57BL/6 Ncr1(gfp/gfp) mice.
|
16565719 |
2006 |
|
Leukemia, Myelocytic, Acute
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, flow cytometry analysis of 20 samples of patients with acute myeloid leukemia (AML) (FAB M0-M5) revealed the expression of NKG2D (40%) and other natural cytotoxicity receptors (40% for NKp30, 74% for NKp44, 39% for NKp46) by a pool >15% of leukemic cells.
|
16239914 |
2005 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.020 |
Biomarker
|
disease |
BEFREE |
Most importantly, we showed that a toxin-conjugated 02 inhibits the growth of NKp46-positive cells; thus, exemplifying the potential of 02 in becoming an immunotherapeutic drug to treat NKp46-dependent diseases, such as, type I diabetes and NK and T cell related malignancies.
|
30536875 |
2019 |
|
Severe Aplastic Anemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Activating receptors NKp46 and NKp44 on CD56<sup>bright</sup> NK cells were upregulated while inhibiting receptor NKG2A was downregulated in SAA.
|
30779419 |
2019 |
|
Complete atrioventricular block
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The expressions of NKp46 and NKG2A were higher in CHB-H than in HS/CHB-L/CHB-NA.
|
28328926 |
2017 |
|
Multiple Sclerosis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Moreover, patients with a first diagnosis of MS display the highest level of NCR1 when compared with patients pharmacologically treated with interferon-beta or natalizumab.
|
25115502 |
2014 |
|
Severe Aplastic Anemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Therefore, we concluded that the decrease of total NK cells, and CD56(bright), CD56(dim) NK cell subsets and the higher expressions of NKp46 and perforin on NK cells may cause the over-function of T lymphocytes and thus lead to hematopoiesis failure in SAA.
|
24661133 |
2014 |
|
Multiple Sclerosis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Rather, the major part of NCR1 expression was localised to astrocytes, and was considerably more pronounced in MS patients than controls.
|
22212381 |
2012 |
|
Complete atrioventricular block
|
0.020 |
Biomarker
|
disease |
BEFREE |
It was found that NKp46(+) NK cells were enriched in the livers of AHB and CHB patients.
|
23133672 |
2012 |
|
leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Thus, IL-15 signaling and NKp46 may be useful targets in the treatment of patients with T-LGL or NKT leukemia.
|
21364281 |
2011 |
|
Childhood Leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Thus, IL-15 signaling and NKp46 may be useful targets in the treatment of patients with T-LGL or NKT leukemia.
|
21364281 |
2011 |