CD36, CD36 molecule, 948

N. diseases: 304; N. variants: 34
Source: BEFREE ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1842090
Disease: Platelet Glycoprotein IV Deficiency
Platelet Glycoprotein IV Deficiency 		0.900 Biomarker disease BEFREE The frequency of CD36 deficiency in northern China was low, all of them were type II deficiency, and no CD36 antibody was detected. 31421121 2019
CUI: C1842090
Disease: Platelet Glycoprotein IV Deficiency
Platelet Glycoprotein IV Deficiency 		0.900 Biomarker disease BEFREE Cases of CD36 deficiency are not rare in Asian populations, foetal and neonatal alloimmune thrombocytopenia (FNAIT) caused by anti-CD36 isoantibodies appears more frequent than other HPA alloantibodies. 28815406 2018
CUI: C1842090
Disease: Platelet Glycoprotein IV Deficiency
Platelet Glycoprotein IV Deficiency 		0.900 GeneticVariation disease BEFREE Sequencing analysis of the CD36 gene was performed to identify the mutation underlying the CD36 deficiency. 29030871 2018
CUI: C1842090
Disease: Platelet Glycoprotein IV Deficiency
Platelet Glycoprotein IV Deficiency 		0.900 AlteredExpression disease BEFREE In this study, we aimed to detect the expression of CD36 in two different chronic epileptic mouse models and determine whether CD36 deficiency leads to suppressive neuronal hyperexcitability and decreased susceptibility of epileptic seizures. 29111364 2017
CUI: C1842090
Disease: Platelet Glycoprotein IV Deficiency
Platelet Glycoprotein IV Deficiency 		0.900 Biomarker disease BEFREE We found four donors (0·6%) with type I CD36 deficiency (both platelets and monocytes CD36(null) ) and six (1·0%) with type II CD36 deficiency (PLT: CD36(null) , monocyte: CD36(low) ). 26528880 2016
CUI: C1842090
Disease: Platelet Glycoprotein IV Deficiency
Platelet Glycoprotein IV Deficiency 		0.900 AlteredExpression disease BEFREE A mouse tumor angiogenesis model revealed enhanced PKD-1 signaling and expression of ephrin B2 and smooth muscle actin in neovessels of Lewis Lung Carcinomas, along with low-CD36 expression or CD36 deficiency. 27013613 2016
CUI: C1842090
Disease: Platelet Glycoprotein IV Deficiency
Platelet Glycoprotein IV Deficiency 		0.900 AlteredExpression disease BEFREE These results demonstrated that the frequencies of Type I (lacking CD36 expression on PLTs and monocytes) and Type II (lacking CD36 expression on PLTs only) CD36 deficiency among the study population were 0.2 and 2.0%, respectively. 25330908 2015
CUI: C1842090
Disease: Platelet Glycoprotein IV Deficiency
Platelet Glycoprotein IV Deficiency 		0.900 GeneticVariation disease BEFREE A total of 22 variants of the CD36 gene were identified, of which five variants (111 A>T, 681 C>A, 1172-1183 del12b, 1236 delT and 1395 A>C) were novel variations, and nine were also found in single nucleotide polymorphism database (dbSNP) but had not been confirmed in individuals with CD36 deficiency. 24960640 2014
CUI: C1842090
Disease: Platelet Glycoprotein IV Deficiency
Platelet Glycoprotein IV Deficiency 		0.900 Biomarker disease BEFREE The role of CD36 was examined in in vitro studies and in vivo experiments, which investigated various functions of CD36 in atherosclerosis and revealed that CD36 deficiency reduces atherosclerotic lesion formation. 24903227 2014
CUI: C1842090
Disease: Platelet Glycoprotein IV Deficiency
Platelet Glycoprotein IV Deficiency 		0.900 Biomarker disease BEFREE Studies on CD36 deficiency in South China: Two cases demonstrating the clinical impact of anti-CD36 antibodies. 23966019 2013
CUI: C1842090
Disease: Platelet Glycoprotein IV Deficiency
Platelet Glycoprotein IV Deficiency 		0.900 GeneticVariation disease BEFREE These results suggest a range of possible explanations including the existence of alternative selection pressures on CD36, co-evolution between host and parasite or confounding caused by allelic heterogeneity of CD36 deficiency. 19403559 2009
CUI: C1842090
Disease: Platelet Glycoprotein IV Deficiency
Platelet Glycoprotein IV Deficiency 		0.900 Biomarker disease BEFREE These results indicate that NAIT is caused by maternal CD36 deficiency having CD36 splicing abnormalities. 18462250 2008
CUI: C1842090
Disease: Platelet Glycoprotein IV Deficiency
Platelet Glycoprotein IV Deficiency 		0.900 AlteredExpression disease BEFREE No CD36 expression in either platelets or monocytes/macrophages was shown using flow cytometer analysis and type I CD36 deficiency was diagnosed. 15912310 2005
CUI: C1842090
Disease: Platelet Glycoprotein IV Deficiency
Platelet Glycoprotein IV Deficiency 		0.900 AlteredExpression disease BEFREE CD36 expression and brain function: does CD36 deficiency impact learning ability? 16099393 2005
CUI: C1842090
Disease: Platelet Glycoprotein IV Deficiency
Platelet Glycoprotein IV Deficiency 		0.900 Biomarker disease BEFREE The cumulative data indicate that CD36 facilitates a major fraction of fatty acid uptake by muscle and fat, and that CD36 deficiency is associated with a large (60-80%) defect in fatty acid uptake by those tissues. 11844979 2002
CUI: C1842090
Disease: Platelet Glycoprotein IV Deficiency
Platelet Glycoprotein IV Deficiency 		0.900 AlteredExpression disease BEFREE To clarify the involvement of the erythroid lineage in CD36 deficiency, we investigated the phenotype and RNA expression of CD36. 11602321 2001
CUI: C1842090
Disease: Platelet Glycoprotein IV Deficiency
Platelet Glycoprotein IV Deficiency 		0.900 Biomarker disease BEFREE To examine the metabolic role of human CD36, we performed a glucose loading test for normals (n = 16) and subjects with CD36 deficiency, both Type I (n = 5) and Type II (n = 16). 11686358 2001
CUI: C1842090
Disease: Platelet Glycoprotein IV Deficiency
Platelet Glycoprotein IV Deficiency 		0.900 AlteredExpression disease BEFREE Flow cytometric analysis of CD36 expression in monocytes and platelets identified a type I CD36 deficiency. 11545201 2001
CUI: C1842090
Disease: Platelet Glycoprotein IV Deficiency
Platelet Glycoprotein IV Deficiency 		0.900 Biomarker disease BEFREE CD36 deficiency is frequent in sub-Saharan Africans; development of anti-CD36 can lead to serious complications in multiply transfused patients, such as those with sicke cell disease. 10504124 1999
CUI: C1842090
Disease: Platelet Glycoprotein IV Deficiency
Platelet Glycoprotein IV Deficiency 		0.900 AlteredExpression disease BEFREE Twenty patients (8%) had type II CD36 deficiency (monocytes expressed CD36 but platelets did not). 9839487 1998
CUI: C1842090
Disease: Platelet Glycoprotein IV Deficiency
Platelet Glycoprotein IV Deficiency 		0.900 GeneticVariation disease BEFREE A single nucleotide insertion in codon 317 of the CD36 gene leads to CD36 deficiency. 8696942 1996
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 GeneticVariation group BEFREE We sequenced coding regions of the cluster of differentiation 36 (CD36) gene in 184 French individuals of European ancestry presenting simultaneously with type 2 diabetes (T2D), arterial hypertension, dyslipidemia, and coronary heart disease. 31748580 2019
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 GeneticVariation group BEFREE Our results suggested that the AA genotype of rs1761667 in the CD36 gene was associated with higher intake of total fat and MUFA and lower risk of hypertension in a Japanese population. 30924431 2019
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 GeneticVariation group BEFREE Furthermore, using a recessive inheritance model CD36 rs1761667 polymorphism was significantly associated with an increased risk of CAD with hypertension (OR = 5.677; 95% CI = 1.053-30.601; p = 0.043). 31185924 2019
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 AlteredExpression group BEFREE : Gene expressions of YKL-40 and CD36 were significantly higher in patients with T2DM (>5 yr) with hypertension compared to healthy controls (P=0.006). 29806605 2018