|
Lupus Erythematosus, Systemic
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
There was no evidence of association for CD40 or CD40L in 408 European-Caucasian families with SLE from UK.
|
15657613 |
2005 |
|
Lupus Erythematosus, Systemic
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The CD154 3'UTR microsatellite is associated with SLE, and the most represented alleles in patients were accompanied by a more prolonged protein expression in activated lymphocytes from controls.
|
14962968 |
2004 |
|
Lupus Erythematosus, Systemic
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Our meta-analyses found associations between <i>CD40</i> rs4810495, rs1883832, and rs376545 polymorphisms and systemic lupus erythematosus susceptibility and significantly higher sCD40 and sCD40L levels in patients with systemic lupus erythematosus than in controls.
|
31570051 |
2019 |
|
Lupus Erythematosus, Systemic
|
0.300 |
Biomarker
|
disease |
BEFREE |
Current evidence shows that the CD40-CD40L system plays a crucial role in the development, progression and outcome of SLE.
|
26289938 |
2016 |
|
Lupus Erythematosus, Systemic
|
0.300 |
Biomarker
|
disease |
BEFREE |
Genetic and functional data suggested the CD40 receptor (CD40) and CD40 ligand (CD40L) as strong candidate genes for SLE.
|
30374748 |
2019 |
|
Lupus Erythematosus, Systemic
|
0.300 |
Biomarker
|
disease |
BEFREE |
Similar studies demonstrated that CD40LG demethylates in CD4(+) T cells from women with lupus, and that women but not men with lupus overexpress CD40LG on CD4(+) T cells, while both overexpress TNFSF7.
|
17947713 |
2007 |
|
Lupus Erythematosus, Systemic
|
0.300 |
Biomarker
|
disease |
BEFREE |
Anti-CD40L immunotherapy in systemic lupus erythematosus patients was associated with thromboembolism of unknown cause.
|
20585032 |
2010 |
|
Lupus Erythematosus, Systemic
|
0.300 |
Biomarker
|
disease |
BEFREE |
Upon stimulation of B cells with IL-2/IL-10, anti-BCR, CpG, and CD40L for 48 hours, the capacity of SLE B cells to up-regulate PD-L1 expression was substantially diminished (P = 0.0006) along with reduced B cell proliferation (P = 0.0039).
|
30919595 |
2019 |
|
Lupus Erythematosus, Systemic
|
0.300 |
Biomarker
|
disease |
BEFREE |
Compared with the normal control group, the expressions of PKCδ, ERK1/2, CD11a, CD70 and CD40L increased, but DNA methylation levels of CD11a, CD70 and CD40L decreased in the SLE control and RA control groups.
|
27915349 |
2016 |
|
Lupus Erythematosus, Systemic
|
0.300 |
Biomarker
|
disease |
BEFREE |
Systemic lupus erythematosus (SLE) is a heterogeneous disease involving several immune cell types and pro-inflammatory signals, including the one triggered by binding of CD40L to the receptor CD40.
|
21415255 |
2011 |
|
Lupus Erythematosus, Systemic
|
0.300 |
Biomarker
|
disease |
BEFREE |
Polymorphisms in several genes were associated with IL-6 levels (including IL10, TYK2, and CD40L in SLE and DRB1, NOD2, and CSF1 in RA) or with TNFα levels (including TNFSF4 and CSF2 in SLE and PTPN2, DRB1, and NOD2 in RA).
|
25652333 |
2015 |
|
Lupus Erythematosus, Systemic
|
0.300 |
Biomarker
|
disease |
BEFREE |
These findings indicate that the estrogen-dependent increase in CD154 in SLE T cells is not due to stability of the mRNA.
|
17211990 |
2006 |
|
Lupus Erythematosus, Systemic
|
0.300 |
Biomarker
|
disease |
MGD |
|
|
|
|
Lupus Erythematosus, Systemic
|
0.300 |
Biomarker
|
disease |
LHGDN |
Platelets from patients with SLE can activate mesangial cells through CD40/CD154 interactions, leading to an induction of proliferation of the mesangial cells and an enhanced production of TGF-beta1, a profibrotic cytokine.
|
16221206 |
2005 |
|
Lupus Erythematosus, Systemic
|
0.300 |
Biomarker
|
disease |
BEFREE |
Epigenetic deregulation of genes encoded on the X chromosome as reported for CD40L in lupus could explain the female predominance of autoimmune diseases.
|
24117612 |
2014 |
|
Lupus Erythematosus, Systemic
|
0.300 |
Biomarker
|
disease |
BEFREE |
The CD40-CD40L pathway is a promising treatment target for autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus and lupus nephritis.
|
29127458 |
2018 |
|
Lupus Erythematosus, Systemic
|
0.300 |
Biomarker
|
disease |
BEFREE |
These data suggest that the presence of two X chromosomes may predispose to SLE, the ligand (CD40 ligand) for one of the genes that contributes to the pathogenesis of SLE being located on the X chromosome.
|
26936892 |
2016 |
|
Lupus Erythematosus, Systemic
|
0.300 |
Biomarker
|
disease |
BEFREE |
The effect of anti-CD40 ligand antibody on B cells in human systemic lupus erythematosus.
|
12115186 |
2002 |
|
Lupus Erythematosus, Systemic
|
0.300 |
Biomarker
|
disease |
BEFREE |
We have previously demonstrated that DNA demethylation of CD40L on the X chromosome is responsible for female susceptibility to systemic lupus erythematosus (SLE).
|
22889643 |
2012 |
|
Lupus Erythematosus, Systemic
|
0.300 |
Biomarker
|
disease |
BEFREE |
These novel findings underscore the multiplicity of pathways through which monocytes may contribute to SLE pathology and suggest that T cell-independent CD40L-mediated cell to cell interactions may be also involved in humoral immune activation in SLE.
|
11987985 |
2002 |
|
Lupus Erythematosus, Systemic
|
0.300 |
Biomarker
|
disease |
BEFREE |
Because hydroxychloroquine (HCQ) has been used frequently in the treatment of lupus, we sought to identify the effects of HCQ on CD154 and a possibly regulatory mechanism.
|
28793932 |
2017 |
|
Lupus Erythematosus, Systemic
|
0.300 |
Biomarker
|
disease |
BEFREE |
This activity was inhibited by anti-CD40L antibody, as well as anti-CD1d antibody, confirming a role for CD40L-CD40 and TCR-CD1d interactions in lupus iNKT-cell-mediated help.
|
25352488 |
2015 |
|
Lupus Erythematosus, Systemic
|
0.300 |
Biomarker
|
disease |
BEFREE |
Culture of SLE T cells in medium containing 2-fluoroestradiol followed by T cell receptor (TCR) activation for 2 h using anti-CD3 resulted in a significant (p = 0.04) estrogen dependent increase in CD40L mRNA.
|
11764210 |
2001 |
|
Lupus Erythematosus, Systemic
|
0.300 |
Biomarker
|
disease |
BEFREE |
Anti-CD40 ligand antibody treatment prevents the development of lupus-like nephritis in a subset of New Zealand black x New Zealand white mice. Response correlates with the absence of an anti-antibody response.
|
8816428 |
1996 |
|
Lupus Erythematosus, Systemic
|
0.300 |
PosttranslationalModification
|
disease |
BEFREE |
Apart from those classic methylation-sensitive autoimmunity-related genes in lupus, such as CD11a (ITGAL), Perforin (PRF1), CD70 (TNFSF7), CD40 ligand (TNFSF5) and PP2Acα, the genome-wide methylation pattern has also been explored recently, providing us a more and more full-scale picture of the abnormal status of DNA methylation in SLE.
|
23340289 |
2013 |