Lupus Erythematosus, Systemic
|
0.300 |
Biomarker
|
disease |
MGD |
|
|
|
Lupus Erythematosus, Systemic
|
0.300 |
Biomarker
|
disease |
BEFREE |
Anti-CD40 ligand antibody treatment prevents the development of lupus-like nephritis in a subset of New Zealand black x New Zealand white mice. Response correlates with the absence of an anti-antibody response.
|
8816428 |
1996 |
Lupus Erythematosus, Systemic
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Levels of CD154 transcripts in SLE blood lymphocytes correlated with the relative concentrations of sCD154 found in SLE plasma.
|
10510335 |
1999 |
Lupus Erythematosus, Systemic
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
3H - TdR incorporation of SLE B cells without stimuli (P<0.001) and with CD40L-LZ stimulation (P<0.05) were significantly lower in SLE patients compared with normal controls.
|
10342716 |
1999 |
Lupus Erythematosus, Systemic
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
This review summarizes the current information regarding transcriptional and post-transcriptional regulation of CD40L expression in normal and SLE T cells.
|
11604589 |
2001 |
Lupus Erythematosus, Systemic
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Here, we demonstrate that the histone deacetylase inhibitor, trichostatin A, significantly down-regulated CD154 and IL-10 and up-regulated IFN-gamma gene expression in SLE T cells.
|
11226290 |
2001 |
Lupus Erythematosus, Systemic
|
0.300 |
Biomarker
|
disease |
BEFREE |
Culture of SLE T cells in medium containing 2-fluoroestradiol followed by T cell receptor (TCR) activation for 2 h using anti-CD3 resulted in a significant (p = 0.04) estrogen dependent increase in CD40L mRNA.
|
11764210 |
2001 |
Lupus Erythematosus, Systemic
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Lupus monocytes clearly overexpressed CD40L comparing to healthy and disease-control monocytes, and, similarly to lupus T cells, displayed a prominent resistance to CsA inhibitory effects.
|
12139375 |
2002 |
Lupus Erythematosus, Systemic
|
0.300 |
Biomarker
|
disease |
BEFREE |
The effect of anti-CD40 ligand antibody on B cells in human systemic lupus erythematosus.
|
12115186 |
2002 |
Lupus Erythematosus, Systemic
|
0.300 |
Biomarker
|
disease |
BEFREE |
These novel findings underscore the multiplicity of pathways through which monocytes may contribute to SLE pathology and suggest that T cell-independent CD40L-mediated cell to cell interactions may be also involved in humoral immune activation in SLE.
|
11987985 |
2002 |
Lupus Erythematosus, Systemic
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Recently, dysregulated expression of CD154 has been noted in a number of autoimmune disorders, including systemic lupus erythematosus (SLE).
|
12857968 |
2003 |
Lupus Erythematosus, Systemic
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, CD40L expression on T cells upon activation was enhanced in SLE patients.
|
12673892 |
2003 |
Lupus Erythematosus, Systemic
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The CD154 3'UTR microsatellite is associated with SLE, and the most represented alleles in patients were accompanied by a more prolonged protein expression in activated lymphocytes from controls.
|
14962968 |
2004 |
Lupus Erythematosus, Systemic
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
There was no evidence of association for CD40 or CD40L in 408 European-Caucasian families with SLE from UK.
|
15657613 |
2005 |
Lupus Erythematosus, Systemic
|
0.300 |
Biomarker
|
disease |
LHGDN |
Platelets from patients with SLE can activate mesangial cells through CD40/CD154 interactions, leading to an induction of proliferation of the mesangial cells and an enhanced production of TGF-beta1, a profibrotic cytokine.
|
16221206 |
2005 |
Lupus Erythematosus, Systemic
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
This has implications for selective targeting of Egr family members to control abnormal expression of CD154 in autoimmune diseases such as systemic lupus erythematosus.
|
16393964 |
2006 |
Lupus Erythematosus, Systemic
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Coexpression of RAG and VpreB or CD154 mRNA could only be found in SLE B cells.
|
16126793 |
2006 |
Lupus Erythematosus, Systemic
|
0.300 |
Biomarker
|
disease |
BEFREE |
These findings indicate that the estrogen-dependent increase in CD154 in SLE T cells is not due to stability of the mRNA.
|
17211990 |
2006 |
Lupus Erythematosus, Systemic
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Nevertheless, although high NF-ATc2 levels translated into higher CD154 transcription in SLE, IL-2 transcription was decreased.
|
17237447 |
2007 |
Lupus Erythematosus, Systemic
|
0.300 |
Biomarker
|
disease |
BEFREE |
Similar studies demonstrated that CD40LG demethylates in CD4(+) T cells from women with lupus, and that women but not men with lupus overexpress CD40LG on CD4(+) T cells, while both overexpress TNFSF7.
|
17947713 |
2007 |
Lupus Erythematosus, Systemic
|
0.300 |
AlteredExpression
|
disease |
LHGDN |
Engagement of beta1 integrin on T cells from patients with active SLE, but not on those from normal individuals, induced cell proliferation as well as CD40L expression on T cells.
|
17469136 |
2007 |
Lupus Erythematosus, Systemic
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that engagement of beta1 integrins on SLE T cells could induce FAK-mediated signaling and subsequent CD40L expression and proliferation.
|
17469136 |
2007 |
Lupus Erythematosus, Systemic
|
0.300 |
AlteredExpression
|
disease |
LHGDN |
The levels of sCD30 and of sCD40L in a group of patients with systemic lupus erythematodes and their diagnostic value.
|
17103120 |
2007 |
Lupus Erythematosus, Systemic
|
0.300 |
AlteredExpression
|
disease |
LHGDN |
Neither cell-surface nor soluble CD154 levels are associated with coronary artery disease in systemic lupus erythematosus.
|
18260168 |
2008 |
Lupus Erythematosus, Systemic
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
We demonstrated that female lupus CD4+ T cells and demethylated CD4+ T cells express high level of CD40LG and overstimulate B cells to produce IgG.
|
19520616 |
2009 |