|
Lupus Erythematosus, Systemic
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Nevertheless, although high NF-ATc2 levels translated into higher CD154 transcription in SLE, IL-2 transcription was decreased.
|
17237447 |
2007 |
|
Lupus Erythematosus, Systemic
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
This has implications for selective targeting of Egr family members to control abnormal expression of CD154 in autoimmune diseases such as systemic lupus erythematosus.
|
16393964 |
2006 |
|
Lupus Erythematosus, Systemic
|
0.300 |
PosttranslationalModification
|
disease |
BEFREE |
Apart from those classic methylation-sensitive autoimmunity-related genes in lupus, such as CD11a (ITGAL), Perforin (PRF1), CD70 (TNFSF7), CD40 ligand (TNFSF5) and PP2Acα, the genome-wide methylation pattern has also been explored recently, providing us a more and more full-scale picture of the abnormal status of DNA methylation in SLE.
|
23340289 |
2013 |
|
Lupus Erythematosus, Systemic
|
0.300 |
Biomarker
|
disease |
BEFREE |
Current evidence shows that the CD40-CD40L system plays a crucial role in the development, progression and outcome of SLE.
|
26289938 |
2016 |
|
Lupus Erythematosus, Systemic
|
0.300 |
Biomarker
|
disease |
BEFREE |
Genetic and functional data suggested the CD40 receptor (CD40) and CD40 ligand (CD40L) as strong candidate genes for SLE.
|
30374748 |
2019 |
|
Lupus Erythematosus, Systemic
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Fr.III cells expressed high levels of ICOS and CD154, but a low level of Tfr and BACH2, BACH2 expression was negatively correlated with SLE Disease Activity Index.
|
31808546 |
2020 |
|
Lupus Erythematosus, Systemic
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Elevated levels of soluble CD40 ligand are associated with antiphospholipid antibodies in patients with systemic lupus erythematosus.
|
28421990 |
2017 |
|
Lupus Erythematosus, Systemic
|
0.300 |
Biomarker
|
disease |
BEFREE |
Similar studies demonstrated that CD40LG demethylates in CD4(+) T cells from women with lupus, and that women but not men with lupus overexpress CD40LG on CD4(+) T cells, while both overexpress TNFSF7.
|
17947713 |
2007 |
|
Lupus Erythematosus, Systemic
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Recently, dysregulated expression of CD154 has been noted in a number of autoimmune disorders, including systemic lupus erythematosus (SLE).
|
12857968 |
2003 |
|
Lupus Erythematosus, Systemic
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
This review summarizes the current information regarding transcriptional and post-transcriptional regulation of CD40L expression in normal and SLE T cells.
|
11604589 |
2001 |
|
Lupus Erythematosus, Systemic
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In this work, we investigated the implication of miR-21 in the experimentally inducible bm12→B6 cGVHD model of systemic lupus erythematosus (SLE). cGVHD host mice deficient in miR-21 show a 2-fold reduction in splenomegaly, significantly reduced autoantibody titers and down-regulated components of the CD40:CD40L and CD28:CD80/86 co-stimulation pathways.
|
26631756 |
2016 |
|
Lupus Erythematosus, Systemic
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Coexpression of RAG and VpreB or CD154 mRNA could only be found in SLE B cells.
|
16126793 |
2006 |
|
Lupus Erythematosus, Systemic
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In systemic lupus erythematosus (SLE) sustained CD40L expression by T cells and platelets activates a variety of cells via its receptor CD40 contributing to disease pathogenesis.
|
21914625 |
2011 |
|
Lupus Erythematosus, Systemic
|
0.300 |
Biomarker
|
disease |
BEFREE |
Anti-CD40L immunotherapy in systemic lupus erythematosus patients was associated with thromboembolism of unknown cause.
|
20585032 |
2010 |
|
Lupus Erythematosus, Systemic
|
0.300 |
Biomarker
|
disease |
BEFREE |
Upon stimulation of B cells with IL-2/IL-10, anti-BCR, CpG, and CD40L for 48 hours, the capacity of SLE B cells to up-regulate PD-L1 expression was substantially diminished (P = 0.0006) along with reduced B cell proliferation (P = 0.0039).
|
30919595 |
2019 |
|
Lupus Erythematosus, Systemic
|
0.300 |
Biomarker
|
disease |
BEFREE |
Compared with the normal control group, the expressions of PKCδ, ERK1/2, CD11a, CD70 and CD40L increased, but DNA methylation levels of CD11a, CD70 and CD40L decreased in the SLE control and RA control groups.
|
27915349 |
2016 |
|
Lupus Erythematosus, Systemic
|
0.300 |
Biomarker
|
disease |
BEFREE |
Systemic lupus erythematosus (SLE) is a heterogeneous disease involving several immune cell types and pro-inflammatory signals, including the one triggered by binding of CD40L to the receptor CD40.
|
21415255 |
2011 |
|
Lupus Erythematosus, Systemic
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Here, we demonstrate that the histone deacetylase inhibitor, trichostatin A, significantly down-regulated CD154 and IL-10 and up-regulated IFN-gamma gene expression in SLE T cells.
|
11226290 |
2001 |
|
Lupus Erythematosus, Systemic
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Lupus monocytes clearly overexpressed CD40L comparing to healthy and disease-control monocytes, and, similarly to lupus T cells, displayed a prominent resistance to CsA inhibitory effects.
|
12139375 |
2002 |
|
Lupus Erythematosus, Systemic
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
CD154 surface protein levels were increased 1.44-fold in CD4 T cells from SLE patients as compared with controls in cells evaluated 1 day postactivation ex vivo.
|
20506525 |
2010 |
|
Lupus Erythematosus, Systemic
|
0.300 |
Biomarker
|
disease |
BEFREE |
Polymorphisms in several genes were associated with IL-6 levels (including IL10, TYK2, and CD40L in SLE and DRB1, NOD2, and CSF1 in RA) or with TNFα levels (including TNFSF4 and CSF2 in SLE and PTPN2, DRB1, and NOD2 in RA).
|
25652333 |
2015 |
|
Lupus Erythematosus, Systemic
|
0.300 |
Biomarker
|
disease |
BEFREE |
These findings indicate that the estrogen-dependent increase in CD154 in SLE T cells is not due to stability of the mRNA.
|
17211990 |
2006 |
|
Lupus Erythematosus, Systemic
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
There was no evidence of association for CD40 or CD40L in 408 European-Caucasian families with SLE from UK.
|
15657613 |
2005 |
|
Lupus Erythematosus, Systemic
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
This suggests that demethylation of genes on the inactive X may predispose women to lupus, and this hypothesis is supported by a report that CD40LG, an immune gene encoded on the X chromosome, demethylates and is overexpressed in T cells from women but not men with lupus.
|
23434382 |
2013 |
|
Lupus Erythematosus, Systemic
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Levels of CD154 transcripts in SLE blood lymphocytes correlated with the relative concentrations of sCD154 found in SLE plasma.
|
10510335 |
1999 |