|
Schizophrenia
|
0.330 |
Biomarker
|
disease |
PSYGENET |
These results provide new evidence that ARHGEF11 may constitute a risk factor for schizophrenia.
|
25319871 |
2014 |
|
Schizophrenia
|
0.330 |
Biomarker
|
disease |
BEFREE |
These results provide new evidence that ARHGEF11 may constitute a risk factor for schizophrenia.
|
25319871 |
2014 |
|
Schizophrenia
|
0.330 |
Biomarker
|
disease |
BEFREE |
We hypothesized that expression of the EAATs and the EAAT regulating proteins ARHGEF11, JWA, G-protein suppressor pathway 1 (GPS1), and KIAA0302 are altered in the brain in schizophrenia.
|
18678470 |
2008 |
|
Schizophrenia
|
0.330 |
Biomarker
|
disease |
PSYGENET |
We hypothesized that expression of the EAATs and the EAAT regulating proteins ARHGEF11, JWA, G-protein suppressor pathway 1 (GPS1), and KIAA0302 are altered in the brain in schizophrenia.
|
18678470 |
2008 |
|
Schizophrenia
|
0.330 |
Biomarker
|
disease |
LHGDN |
Expression of ARHGEF11 mRNA in schizophrenic thalamus.
|
14684465 |
2003 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Characterizing rare and low-frequency height-associated variants in the Japanese population.
|
31562340 |
2019 |
|
Red Blood Cell Count measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Intelligence
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.
|
29844566 |
2018 |
|
White Blood Cell Count procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Genome-wide association study of white blood cell count in 16,388 African Americans: the continental origins and genetic epidemiology network (COGENT).
|
21738479 |
2011 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
We selected eight single nucleotide polymorphisms of ARHGEF11 that had significant associations with T2DM for a case-control association study of 490 patients with schizophrenia and 500 age-matched and sex-matched controls.
|
25319871 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
Our investigation suggests that the R1467H polymorphism of ARHGEF11 gene may contribute to susceptibility to T2DM and insulin resistance in a Chinese population.
|
21210224 |
2011 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
Our study replicated associations of the R1467H with increased risk of T2D or T2D/IGT, thus, implicating a potential role of ARHGEF11 in the aetiology of T2D and IGT.
|
18231709 |
2008 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that variation within ARHGEF11 nominally increases risk of type 2 diabetes, possibly as a result of increased insulin resistance.
|
17287471 |
2007 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
These results, coupled with similar findings in Pima Indians, suggest that sequence variation in ARHGEF11 may influence risk of type 2 diabetes.
|
17369523 |
2007 |
|
Tumor Cell Invasion
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
PDZ-RhoGEF is overexpressed in glioblastoma tumors and stimulates glioma cell invasion via Rho activation.
|
30219706 |
2018 |
|
Tumor Cell Invasion
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Depletion of PDZ-RhoGEF, or β-arr1, or RhoC, as well as the treatment with the dual ET-1 receptor antagonist macitentan, significantly impairs invadopodia function, MMP activity and invasion, demonstrating that β-arr1/PDZ-RhoGEF interaction mediates ETAR-driven ROCK-LIMK-cofilin pathway through the control of RhoC activity.
|
26522724 |
2016 |
|
Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
PDZ-RhoGEF is overexpressed in glioblastoma tumors and stimulates glioma cell invasion via Rho activation.
|
30219706 |
2018 |
|
Glioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Conversely, silencing PDZ-RhoGEF expression inhibited TROY-induced glioma cell migration, increased sensitivity to temozolomide treatment, and extended survival of orthotopic xenograft mice.
|
30219706 |
2018 |
|
Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
PDZ-RhoGEF is overexpressed in glioblastoma tumors and stimulates glioma cell invasion via Rho activation.
|
30219706 |
2018 |
|
Gestational Diabetes
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Among these SNPs, we report for the first time that rs945508 in ARHGEF11, rs10804591 in PLXND1 and rs10245353 in NFE2L3 were associated with GDM.
|
28554271 |
2018 |
|
Adult Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
PDZ-RhoGEF is overexpressed in glioblastoma tumors and stimulates glioma cell invasion via Rho activation.
|
30219706 |
2018 |
|
Childhood Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
PDZ-RhoGEF is overexpressed in glioblastoma tumors and stimulates glioma cell invasion via Rho activation.
|
30219706 |
2018 |
|
Glioblastoma Multiforme
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
PDZ-RhoGEF is overexpressed in glioblastoma tumors and stimulates glioma cell invasion via Rho activation.
|
30219706 |
2018 |
|
Malignant neoplasm of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings show that the expression of the particular splice isoform of ARHGEF11 is critically linked to the malignant phenotype of breast cancer cells, identifying ARHGEF11 exon 38(+) as a biomarker and target for therapy of breast cancer.
|
29190905 |
2017 |
|
Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings show that the expression of the particular splice isoform of ARHGEF11 is critically linked to the malignant phenotype of breast cancer cells, identifying ARHGEF11 exon 38(+) as a biomarker and target for therapy of breast cancer.
|
29190905 |
2017 |