|
rs1763908
|
ARHGEF11
|
Red Blood Cell Count measurement
|
|
0.700 |
GeneticVariation |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
rs6686367
|
ARHGEF11
|
Body Height
|
|
0.700 |
GeneticVariation |
GWASCAT |
Characterizing rare and low-frequency height-associated variants in the Japanese population.
|
31562340 |
2019 |
|
rs2275200
|
ARHGEF11;LRRC71
|
Intelligence
|
|
0.700 |
GeneticVariation |
GWASCAT |
Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.
|
29844566 |
2018 |
|
rs6427339
|
ARHGEF11
|
White Blood Cell Count procedure
|
|
0.700 |
GeneticVariation |
GWASDB |
Genome-wide association study of white blood cell count in 16,388 African Americans: the continental origins and genetic epidemiology network (COGENT).
|
21738479 |
2011 |
|
rs6427340
|
ARHGEF11
|
White Blood Cell Count procedure
|
|
0.700 |
GeneticVariation |
GWASDB |
Genome-wide association study of white blood cell count in 16,388 African Americans: the continental origins and genetic epidemiology network (COGENT).
|
21738479 |
2011 |
|
rs945508
|
ARHGEF11;LRRC71;MIR765
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.030 |
GeneticVariation |
BEFREE |
Our investigation suggests that the R1467H polymorphism of ARHGEF11 gene may contribute to susceptibility to T2DM and insulin resistance in a Chinese population.
|
21210224 |
2011 |
|
rs945508
|
ARHGEF11;LRRC71;MIR765
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.030 |
GeneticVariation |
BEFREE |
Our study replicated associations of the R1467H with increased risk of T2D or T2D/IGT, thus, implicating a potential role of ARHGEF11 in the aetiology of T2D and IGT.
|
18231709 |
2008 |
|
rs945508
|
ARHGEF11;LRRC71;MIR765
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.030 |
GeneticVariation |
BEFREE |
An R1467H in ARHGEF11, and several additional noncoding variants that were in high linkage disequilibrium with this variant, were nominally associated with young-onset type 2 diabetes (P = 0.01; odds ratio 3.39) after adjusting for sex, family membership, and Pima heritage.
|
17287471 |
2007 |
|
rs945508
|
ARHGEF11;LRRC71;MIR765
|
Gestational Diabetes
|
|
0.010 |
GeneticVariation |
BEFREE |
Among these SNPs, we report for the first time that rs945508 in ARHGEF11, rs10804591 in PLXND1 and rs10245353 in NFE2L3 were associated with GDM.
|
28554271 |
2018 |
|
rs6427339
|
ARHGEF11
|
Schizophrenia
|
|
0.010 |
GeneticVariation |
BEFREE |
Analysis of the rs6427340-rs64</span>27339 haplotype and the rs822585-rs6427340-rs6427339</span> haplotype combination provided significant evidence of an association with schizophrenia (global permutations p = 0.00047 and 0.0032, respectively).
|
25319871 |
2014 |
|
rs6427340
|
ARHGEF11
|
Schizophrenia
|
|
0.010 |
GeneticVariation |
BEFREE |
Analysis of the rs64</span>27340-rs6427339 haplotype and the rs822585-rs6427340</span>-rs6427339 haplotype combination provided significant evidence of an association with schizophrenia (global permutations p = 0.00047 and 0.0032, respectively).
|
25319871 |
2014 |
|
rs822585
|
ARHGEF11
|
Schizophrenia
|
|
0.010 |
GeneticVariation |
BEFREE |
Analysis of the rs6427340-rs6427339 haplotype and the rs822585</span>-rs6427340-rs6427339 haplotype combination provided significant evidence of an association with schizophrenia (global permutations p = 0.00047 and 0.0032, respectively).
|
25319871 |
2014 |
|
rs7550260
|
ARHGEF11
|
Intracranial Aneurysm
|
|
0.010 |
GeneticVariation |
BEFREE |
Consequently, five SNPs (P=1.31 × 10(-5) for rs1930095 of intergenic region; P=1.32 × 10(-5) for rs4628172 of TMEM195; P=2.78 × 10(-5) for rs7781293 of TMEM195; P=4.93 × 10(-5) for rs7550260 of ARHGEF11; and P=3.63 × 10(-5) for rs9864101 of IQSEC1) with probabilities of being false positives <0.5 were associated with IA in Japanese population, and the susceptibility genes could have a role in actin remodeling in the ELN/LIMK pathway.
|
20613766 |
2010 |
|
rs945508
|
ARHGEF11;LRRC71;MIR765
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study replicated associations of the R1467H with increased risk of T2D or T2D/IGT, thus, implicating a potential role of ARHGEF11 in the aetiology of T2D and IGT.
|
18231709 |
2008 |
|
rs6427340
|
ARHGEF11
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.010 |
GeneticVariation |
BEFREE |
In an expanded set of nondiabetic subjects (n = 754), most of the type 2 diabetes-and IGT-associated SNPs were significantly associated with glucose levels during an oral glucose tolerance test, with the same SNP (rs6427340) showing the most significant associations (P = 0.007).
|
17369523 |
2007 |
|
rs868188
|
ARHGEF11;LRRC71;MIR765
|
Primary malignant neoplasm of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
For the current report, the authors studied the risk of lung cancer associated with a nonsynonymous SNP (rs868188; Ser1416Gly) in PDZ-RhoGEF in a large lung cancer case-control study of 2260 Caucasians and 369 Mexican Americans.
|
16691626 |
2006 |
|
rs868188
|
ARHGEF11;LRRC71;MIR765
|
Malignant neoplasm of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
For the current report, the authors studied the risk of lung cancer associated with a nonsynonymous SNP (rs868188; Ser1416Gly) in PDZ-RhoGEF in a large lung cancer case-control study of 2260 Caucasians and 369 Mexican Americans.
|
16691626 |
2006 |
|
rs868188
|
ARHGEF11;LRRC71;MIR765
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
For the current report, the authors studied the risk of lung cancer associated with a nonsynonymous SNP (rs868188; Ser1416Gly) in PDZ-RhoGEF in a large lung cancer case-control study of 2260 Caucasians and 369 Mexican Americans.
|
16691626 |
2006 |