|
Hepatitis, Toxic
|
0.300 |
Biomarker
|
disease |
CTD_human |
Characterization of chemically induced liver injuries using gene co-expression modules.
|
25226513 |
2014 |
|
Heart Failure, Diastolic
|
0.300 |
Biomarker
|
disease |
CTD_human |
In Silico Analysis of Differential Gene Expression in Three Common Rat Models of Diastolic Dysfunction.
|
29556499 |
2018 |
|
Hepatitis, Drug-Induced
|
0.300 |
Biomarker
|
disease |
CTD_human |
Characterization of chemically induced liver injuries using gene co-expression modules.
|
25226513 |
2014 |
|
Drug-Induced Acute Liver Injury
|
0.300 |
Biomarker
|
disease |
CTD_human |
Characterization of chemically induced liver injuries using gene co-expression modules.
|
25226513 |
2014 |
|
Chemical and Drug Induced Liver Injury
|
0.300 |
Biomarker
|
disease |
CTD_human |
Characterization of chemically induced liver injuries using gene co-expression modules.
|
25226513 |
2014 |
|
Chemically-Induced Liver Toxicity
|
0.300 |
Biomarker
|
disease |
CTD_human |
Characterization of chemically induced liver injuries using gene co-expression modules.
|
25226513 |
2014 |
|
Bipolar Disorder
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder.
|
21254220 |
2011 |
|
Bipolar Disorder
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder.
|
21254220 |
2011 |
|
Squamous cell carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of CDC25B and LAMC2 mRNA and protein in esophageal squamous cell carcinomas and premalignant lesions in subjects from a high-risk population in China.
|
18559558 |
2008 |
|
Squamous cell carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
CDC25B was primarily cytoplasmic in skin and skin tumors and was significantly increased in the squamous cell carcinoma (SCC), while CDC25C was mostly nuclear in the skin, with an increased cytoplasmic signal in the premalignant and malignant tumors.
|
31237025 |
2019 |
|
Squamous cell carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
To identify pretreatment markers predicting response and survival, we examined the expression of cell cycle regulatory molecules, p53, p21(Waf1/Cip1) cyclin D1, and CDC25B, in biopsy specimens from 76 patients with stage III and stage IV squamous cell carcinoma.
|
15569370 |
2004 |
|
Squamous cell carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Clinical significance of CDC25A and CDC25B expression in squamous cell carcinomas of the oesophagus.
|
11487274 |
2001 |
|
Squamous cell carcinoma
|
0.040 |
AlteredExpression
|
disease |
LHGDN |
Overexpression of CDC25B and LAMC2 mRNA and protein in esophageal squamous cell carcinomas and premalignant lesions in subjects from a high-risk population in China.
|
18559558 |
2008 |
|
Esophageal carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Low expression of (or IHC-negative) COX2, miR-200c, ERCC1 and TS, or high expression of (or IHC-positive) CDC25B and p16 are potential biomarkers for predicting the response of esophageal cancer patients treated with chemo(radio)therapy.
|
29113666 |
2017 |
|
Esophageal carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In this study, we investigated the effect of CDC25B overexpression on radiation-induced G2-M arrest and radiation sensitivity in esophageal cancer cells.
|
11306507 |
2001 |
|
Esophageal carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Fluorescence quantitative real-time PCR and immunohistochemistry methods were used to analyze the expression of CDC25B, PED/PEA-15 in esophageal carcinoma.
|
25775393 |
2015 |
|
Liver carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The mechanism of resistance to HCC development is associated with nuclear accumulation of the cell cycle inhibitor p27(Kip1) protein and reduced expression of the Cdk1-activator Cdc25B phosphatase.
|
15082532 |
2004 |
|
Liver carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemistry of 59 HCCs showed marked increase in CDC25A expression, but not CDC25B, in HCC compared with noncancer tissues, and high expression of CDC25A in 33 of 59 (56%) HCCs.
|
12738732 |
2003 |
|
Liver carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
SNHG16 as the miRNA let-7b-5p sponge facilitates the G2/M and epithelial-mesenchymal transition by regulating CDC25B and HMGA2 expression in hepatocellular carcinoma.
|
31696971 |
2020 |
|
Leukemia, Myelocytic, Acute
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In summary, we found that transcriptional repression mediated by IER5 regulates Cdc25B expression levels via the release of NF-YB and p300 in AML-derived ALDH(hi)/CD34(+) cells, resulting in inhibition of AML progenitor cell proliferation through modulation of cell cycle.
|
22132193 |
2011 |
|
Leukemia, Myelocytic, Acute
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Global gene expression analyses showed that patients with AML cell resistance against PI3K-mTOR inhibitors showed increased mRNA expression of the CDC25B gene that encodes the cell cycle regulator Cell Division Cycle 25B.
|
24383842 |
2014 |
|
Pancreatic carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
We decided to construct a novel oncolytic adenovirus whose replication was driven by the CDC25B promoter for its use in preclinical models of pancreatic cancer.
|
25573380 |
2015 |
|
Pancreatic carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
By quantitative RT-PCR, CDC25B mRNA was overexpressed in pancreatic cancer (7.5-fold) in comparison to the normal pancreas.
|
14712212 |
2004 |
|
Squamous cell carcinoma of esophagus
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The immunostaining results showed that Fra-1, Neogenin, Id-1, and CDC25B were overexpressed in both ESCC cell lines and their corresponding primary tumors at the protein level, validating the microarray findings.
|
11489794 |
2001 |
|
Squamous cell carcinoma of esophagus
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
CDC25B protein expression scores in subjects with esophageal biopsies diagnosed as normal (n = 35), dysplastic (n = 23), or ESCC (n = 32) increased significantly with morphologic progression.
|
18559558 |
2008 |