|
Malignant neoplasm of skin
|
0.010 |
Biomarker
|
disease |
BEFREE |
We found that CDC25B and CDC25C were increased in mouse and human skin cancers.
|
31237025 |
2019 |
|
Colorectal Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Rescue assays illustrated that CDC25B overexpression reversed the suppressive effects of hsa_circRNA_102958 silencing on CRC.
|
31413634 |
2019 |
|
Precancerous Conditions
|
0.010 |
Biomarker
|
group |
BEFREE |
CDC25B was primarily cytoplasmic in skin and skin tumors and was significantly increased in the squamous cell carcinoma (SCC), while CDC25C was mostly nuclear in the skin, with an increased cytoplasmic signal in the premalignant and malignant tumors.
|
31237025 |
2019 |
|
Skin Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
CDC25B was primarily cytoplasmic in skin and skin tumors and was significantly increased in the squamous cell carcinoma (SCC), while CDC25C was mostly nuclear in the skin, with an increased cytoplasmic signal in the premalignant and malignant tumors.
|
31237025 |
2019 |
|
Uveal melanoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
SCD5, SPTBN1, FABP5, SQLE, PTPLA (HACD1), and CDC25B transcription levels were of high prognostic value, which might assist us to understand the underlying carcinogenesis or advancement of UVM better.
|
31270856 |
2019 |
|
Skin carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
CDC25B and CDC25C overexpression in nonmelanoma skin cancer suppresses cell death.
|
31237025 |
2019 |
|
ovarian neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The inhibition of CDC25B by WG-391D is irreversible, and WG-391D should therefore exhibit potent antitumor activity against ovarian cancer.
|
31024841 |
2019 |
|
Malignant neoplasm of ovary
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The inhibition of CDC25B by WG-391D is irreversible, and WG-391D should therefore exhibit potent antitumor activity against ovarian cancer.
|
31024841 |
2019 |
|
Carcinoma, Ovarian Epithelial
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The inhibition of CDC25B by WG-391D is irreversible, and WG-391D should therefore exhibit potent antitumor activity against ovarian cancer.
|
31024841 |
2019 |
|
Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
mRNA profiling identifies low levels of phosphatases dual‐specific phosphatase‐7 (DUSP7) and cell division cycle‐25B (CDC25B) in patients with early arthritis.
|
28253537 |
2017 |
|
Autoimmune arthritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Low levels of CDC25B might contribute to the progression of the autoimmune arthritis and/or might be consequence of the inflammatory environment in the active disease.
|
28253537 |
2017 |
|
Cocaine Abuse
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study is to elucidate the molecular mechanism of HIV associated neuropathogenesis in cocaine abuse and how it accelerates the energy sensor AMPKs and its subsequent effect on mitochondrial oxidative phosphorylation (OXPHOS), BRSKs, CDC25B/C, MAP/Tau, Wee1 and epigenetics remodeling complex SWI/SNF.
|
27535703 |
2016 |
|
HIV Infections
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Results showed that cocaine exposure during HIV infection significantly increased the level of p24, reactive oxygen species (ROS), ATP-utilization and upregulated energy sensor AMPKs, CDC25B/C, MAP/Tau and Wee1 protein expression.
|
27535703 |
2016 |
|
Neoplasm Metastasis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
YWHAE silencing induces cell proliferation, invasion and migration through the up-regulation of CDC25B and MYC in gastric cancer cells: new insights about YWHAE role in the tumor development and metastasis process.
|
27863420 |
2016 |
|
Pancreatic Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
A Novel CDC25B Promoter-Based Oncolytic Adenovirus Inhibited Growth of Orthotopic Human Pancreatic Tumors in Different Preclinical Models.
|
25573380 |
2015 |
|
Retinoblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that expression of CDC25B may be used as a potential prognostic marker in the pathogenesis of retinoblastoma.
|
25326518 |
2015 |
|
Breast Carcinoma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
6,7-di-O-acetylsinococuline (FK-3000) induces G2/M phase arrest in breast carcinomas through p38 MAPK phosphorylation and CDC25B dephosphorylation.
|
25384584 |
2015 |
|
Triple Negative Breast Neoplasms
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
For the first time, we demonstrate that miRNA-211 is a direct negative regulator of CDC25B expression in TNBC cells, alters other related target proteins CCNB1 and FOXM1, and then inhibits breast cancer cells growth, migration, and invasion and lead G2/M arrest.
|
25680404 |
2015 |
|
Triple-Negative Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
For the first time, we demonstrate that miRNA-211 is a direct negative regulator of CDC25B expression in TNBC cells, alters other related target proteins CCNB1 and FOXM1, and then inhibits breast cancer cells growth, migration, and invasion and lead G2/M arrest.
|
25680404 |
2015 |
|
Renal Cell Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
To additionally investigate the role of Cdc25B alteration in the development of renal cell carcinoma, Cdc25B siRNA was used to knockdown the expression of Cdc25B.
|
22631674 |
2012 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
To additionally investigate the role of Cdc25B alteration in the development of renal cell carcinoma, Cdc25B siRNA was used to knockdown the expression of Cdc25B.
|
22631674 |
2012 |
|
Non-Small Cell Lung Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
54 potentially functional polymorphisms in key cell cycle genes (CDK1, CDK2, CDK4, CDK6, CDK7, CCND1, CCND2, CCND3, CCNE1, CCNA1, CCNA2, CCNB1, CCNH, p15, p16, p18, p19, p21, p27, Cdc25A and Cdc25B) were genotyped by using Illumina SNP genotyping platform to evaluate their associations with survival of NSCLC in a clinical cohort of 568 patients.
|
21145615 |
2011 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
Biomarker
|
disease |
BEFREE |
In summary, we identified CDC25B as a novel miR-148a target which may confer a proliferative advantage in PDAC.
|
21709669 |
2011 |
|
Asthenozoospermia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The messenger RNA (mRNA) transcript level of CDC25B was increased in sperm samples of men with asthenospermia.
|
17336969 |
2007 |
|
Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
High expression of CDC25B was identified in 18 of the 19 glioblastomas, in 10 of the 17 anaplastic astrocytomas, but not in any of the 21 low-grade astrocytomas.
|
16803948 |
2006 |