|
Adenocarcinoma Of Esophagus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Nine genes were up-regulated in oesophageal adenocarcinoma tissue (matrix metalloproteinase 11 (MMP11), ornithine decarboxylase (ODC), cytokeratins 8 and 18, integrin alpha 3 (ITGA3), integrin alpha 6 (ITGA6), BIGH3 (transforming growth factor beta-induced), beta-catenin and CDC25B (M-phase inducer phosphatase 2)).
|
12680208 |
2003 |
|
Adult Lymphoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A biallelic EcoRI polymorphism of cdc25B gene was identified with a similar distribution in patients with lymphoma and in a normal population. cdc25A was overexpressed in three aggressive lymphomas.
|
9563496 |
1998 |
|
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
To explain the atypical activation of Cdc2/cyclin B in degenerating neurons we have investigated the enzyme responsible for Cdc2/cyclin B activation in mitotic cells, i.e. the Cdc25B tyrosine phosphatase, in Alzheimer's disease brain.
|
11516829 |
2001 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
Biomarker
|
disease |
BEFREE |
In summary, we identified CDC25B as a novel miR-148a target which may confer a proliferative advantage in PDAC.
|
21709669 |
2011 |
|
Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
mRNA profiling identifies low levels of phosphatases dual‐specific phosphatase‐7 (DUSP7) and cell division cycle‐25B (CDC25B) in patients with early arthritis.
|
28253537 |
2017 |
|
Asthenozoospermia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The messenger RNA (mRNA) transcript level of CDC25B was increased in sperm samples of men with asthenospermia.
|
17336969 |
2007 |
|
Autoimmune arthritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Low levels of CDC25B might contribute to the progression of the autoimmune arthritis and/or might be consequence of the inflammatory environment in the active disease.
|
28253537 |
2017 |
|
Bipolar Disorder
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder.
|
21254220 |
2011 |
|
Bipolar Disorder
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder.
|
21254220 |
2011 |
|
Breast Carcinoma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
6,7-di-O-acetylsinococuline (FK-3000) induces G2/M phase arrest in breast carcinomas through p38 MAPK phosphorylation and CDC25B dephosphorylation.
|
25384584 |
2015 |
|
Carcinogenesis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
In the tumor initiation, the opposite role of YWHAE and CDC25B in gastric carcinogenesis seems to be independent of MYC expression.
|
27863420 |
2016 |
|
Carcinogenesis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
Inhibition of CDC25B With WG-391D Impedes the Tumorigenesis of Ovarian Cancer.
|
31024841 |
2019 |
|
Carcinogenesis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
Both CDC25B and PED/PEA-15 play a certain role in the carcinogenesis of esophageal cancer, and PED/PEA-15 has a greater influence on postoperative survival time.
|
25775393 |
2015 |
|
Carcinogenesis
|
0.070 |
AlteredExpression
|
phenotype |
BEFREE |
We postulate that the induction of Cdc25B expression in lung cancer cells by the ultimate carcinogen anti-BPDE accelerates the further development of lung carcinogenesis.
|
12591724 |
2003 |
|
Carcinogenesis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
CDC25B is a cell-cycle regulatory protein, which is considered to be related to tumorigenesis and progression of tumours.
|
16803948 |
2006 |
|
Carcinogenesis
|
0.070 |
AlteredExpression
|
phenotype |
BEFREE |
SCD5, SPTBN1, FABP5, SQLE, PTPLA (HACD1), and CDC25B transcription levels were of high prognostic value, which might assist us to understand the underlying carcinogenesis or advancement of UVM better.
|
31270856 |
2019 |
|
Carcinogenesis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
Collectively, our study demonstrate that KCTD12 binds to CDC25B and activates CDK1 and Aurora A to facilitate the G2/M transition and promote tumorigenesis and that Aurora A phosphorylates KCTD12 at serine 243 to trigger a positive feedback loop, thereby potentiating the effects of KCTD12.
|
28869606 |
2017 |
|
Carcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The expression levels of CDC25B were generally higher than those of CDC25A and C. Of the 40 gastric carcinomas, 70% of the tumors expressed CDC25B mRNA at higher levels than the corresponding normal mucosas, while 38% overexpressed CDC25A mRNA.
|
9414655 |
1997 |
|
Carcinoma of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We postulate that the induction of Cdc25B expression in lung cancer cells by the ultimate carcinogen anti-BPDE accelerates the further development of lung carcinogenesis.
|
12591724 |
2003 |
|
Carcinoma, Ovarian Epithelial
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The inhibition of CDC25B by WG-391D is irreversible, and WG-391D should therefore exhibit potent antitumor activity against ovarian cancer.
|
31024841 |
2019 |
|
Central neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, we suggest that cdc25B may play an active role as a target of N-myc in neuroblastoma, although the biological function of cdc25B in neuroblastoma remains to be clarified.
|
11689596 |
2001 |
|
Chemical and Drug Induced Liver Injury
|
0.300 |
Biomarker
|
disease |
CTD_human |
Characterization of chemically induced liver injuries using gene co-expression modules.
|
25226513 |
2014 |
|
Chemically-Induced Liver Toxicity
|
0.300 |
Biomarker
|
disease |
CTD_human |
Characterization of chemically induced liver injuries using gene co-expression modules.
|
25226513 |
2014 |
|
Childhood Lymphoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A biallelic EcoRI polymorphism of cdc25B gene was identified with a similar distribution in patients with lymphoma and in a normal population. cdc25A was overexpressed in three aggressive lymphomas.
|
9563496 |
1998 |
|
Childhood Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, we suggest that cdc25B may play an active role as a target of N-myc in neuroblastoma, although the biological function of cdc25B in neuroblastoma remains to be clarified.
|
11689596 |
2001 |