|
rs12936511
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Abnormal behavior
|
|
0.010 |
GeneticVariation |
BEFREE |
The minor T-allele of exonic SNP rs12936511, not previously studied in the context of psychiatric disorders and suicidal behaviors, was significantly transmitted to suicidal males with increased Beck Depression Inventory (BDI) scores (n = 347; P = 0.0028).
|
19220485 |
2009 |
|
rs110402
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Alcohol Use Disorder
|
|
0.010 |
GeneticVariation |
BEFREE |
An interaction of CRHR1 rs110402 and CRHBP rs3811939 predicts high risk of comorbid AUD in schizophrenic patients (odds ratio = 2.27; 95% confidence interval, 1.56-3.30; P < .001) as well as psychiatric disease controls (odds ratio = 4.02; 95% confidence interval, 0.95-17.05; P = .06) and leads to the highest CRHR1/CRHBP messenger RNA ratio (P = .02; dysbalanced stress axis).
|
21810631 |
2011 |
|
rs110402
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Alcoholic Intoxication, Chronic
|
|
0.010 |
GeneticVariation |
BEFREE |
This study examined the influence of an intronic CRHR1 gene variant, rs110402, on brain responses to negative emotional words, negative emotional traits, and alcohol use in adolescents and young adults at high risk for alcoholism.
|
24623788 |
2014 |
|
rs173365
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Alcoholic Intoxication, Chronic
|
|
0.010 |
GeneticVariation |
BEFREE |
In block 2, rs17689966 (P = 0.018) showed significant and rs173365 (P = 0.026) showed nominally significant, gene × environment (G × E) effects on alcoholism status.
|
23473364 |
2013 |
|
rs17689966
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Alcoholic Intoxication, Chronic
|
|
0.010 |
GeneticVariation |
BEFREE |
In block 2, rs17689966 (P = 0.018) showed significant and rs173365 (P = 0.026) showed nominally significant, gene × environment (G × E) effects on alcoholism status.
|
23473364 |
2013 |
|
rs17762954
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Alopecia, Male Pattern
|
|
0.700 |
GeneticVariation |
GWASDB |
Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases.
|
22693459 |
2012 |
|
rs242941
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV.
|
23157339 |
2013 |
|
rs17689918
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Antisocial behavior
|
|
0.010 |
GeneticVariation |
BEFREE |
We assess the effects of CRHR1 variant (rs17689918)-by-environment interactions on emotionality and behavioral traits, including anxiety, depression, aggression and antisocial behaviors.
|
29772307 |
2018 |
|
rs110402
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Anxiety
|
|
0.020 |
GeneticVariation |
BEFREE |
It has been proposed that the common intronic CRHR1 SNP rs110402 is associated with anxiety and cortisol response patterns and plays a key role in vulnerability to certain mental disorders.
|
30447186 |
2019 |
|
rs110402
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Anxiety
|
|
0.020 |
GeneticVariation |
BEFREE |
We observed interactions between trait anxiety and rs7209436 and rs110402 in CRHR1 in association with baseline cortisol (p LRT = 0.0272 and p LRT = 0.0483, respectively).
|
23274505 |
2013 |
|
rs17689918
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Anxiety
|
|
0.010 |
GeneticVariation |
BEFREE |
When investigating neural correlates underlying this association in patients with PD using functional magnetic resonance imaging, risk allele carriers of rs17689918 showed aberrant differential conditioning predominantly in the bilateral prefrontal cortex and safety signal processing in the amygdalae, arguing for predominant generalization of fear and hence anxious apprehension.
|
26324098 |
2016 |
|
rs7209436
|
CRHR1;LINC02210-CRHR1
|
Anxiety
|
|
0.010 |
GeneticVariation |
BEFREE |
We observed interactions between trait anxiety and rs7209436 and rs110402 in CRHR1 in association with baseline cortisol (p LRT = 0.0272 and p LRT = 0.0483, respectively).
|
23274505 |
2013 |
|
rs110402
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Anxiety Disorders
|
|
0.030 |
GeneticVariation |
BEFREE |
It has been proposed that the common intronic CRHR1 SNP rs110402 is associated with anxiety and cortisol response patterns and plays a key role in vulnerability to certain mental disorders.
|
30447186 |
2019 |
|
rs110402
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Anxiety Disorders
|
|
0.030 |
GeneticVariation |
BEFREE |
Here, we provide clinical translation for the importance of these molecular interactions using an imaging genetics strategy to examine whether interactions between genetic polymorphisms associated with differential anandamide (FAAH rs324420) and CRF1 (CRHR1 rs110402) signaling modulate amygdala function and anxiety disorder diagnosis.
|
26923505 |
2016 |
|
rs110402
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Anxiety Disorders
|
|
0.030 |
GeneticVariation |
BEFREE |
We observed interactions between trait anxiety and rs7209436 and rs110402 in CRHR1 in association with baseline cortisol (p LRT = 0.0272 and p LRT = 0.0483, respectively).
|
23274505 |
2013 |
|
rs7209436
|
CRHR1;LINC02210-CRHR1
|
Anxiety Disorders
|
|
0.010 |
GeneticVariation |
BEFREE |
We observed interactions between trait anxiety and rs7209436 and rs110402 in CRHR1 in association with baseline cortisol (p LRT = 0.0272 and p LRT = 0.0483, respectively).
|
23274505 |
2013 |
|
rs1876828
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Asthma
|
|
0.010 |
GeneticVariation |
BEFREE |
Eighty-two children (56 boys/26 girls, mean age 9.6 ± 3.2 years) with moderate-severe asthma exacerbation were genotyped for eight single-nucleotide polymorphisms that were a priori associated with ICS response in chronic asthma treatment: glucocorticosteroid receptor (NR3C1) rs41423247; corticotrophin-releasing hormone receptor1 (CRHR1) rs242939, rs242941, and rs1876828; T-box 21 (TBX21) rs2240017; glucocorticoid-induced transcript 1 (GLCCl1); and T gene rs3099266 and rs2305089.
|
27003716 |
2016 |
|
rs242939
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Asthma
|
|
0.010 |
GeneticVariation |
BEFREE |
Eighty-two children (56 boys/26 girls, mean age 9.6 ± 3.2 years) with moderate-severe asthma exacerbation were genotyped for eight single-nucleotide polymorphisms that were a priori associated with ICS response in chronic asthma treatment: glucocorticosteroid receptor (NR3C1) rs41423247; corticotrophin-releasing hormone receptor1 (CRHR1) rs242939, rs242941, and rs1876828; T-box 21 (TBX21) rs2240017; glucocorticoid-induced transcript 1 (GLCCl1); and T gene rs3099266 and rs2305089.
|
27003716 |
2016 |
|
rs242941
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Asthma
|
|
0.010 |
GeneticVariation |
BEFREE |
Eighty-two children (56 boys/26 girls, mean age 9.6 ± 3.2 years) with moderate-severe asthma exacerbation were genotyped for eight single-nucleotide polymorphisms that were a priori associated with ICS response in chronic asthma treatment: glucocorticosteroid receptor (NR3C1) rs41423247; corticotrophin-releasing hormone receptor1 (CRHR1) rs242939, rs242941, and rs1876828; T-box 21 (TBX21) rs2240017; glucocorticoid-induced transcript 1 (GLCCl1); and T gene rs3099266 and rs2305089.
|
27003716 |
2016 |
|
rs778136105
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Asthma
|
|
0.010 |
GeneticVariation |
BEFREE |
Early studies suggest that bronchodilator reversibility and asthma worsening in patients on continuous short-acting and long-acting beta-agonists are related to the Gly16Arg genotype for the ADRB2.
|
19077707 |
2009 |
|
rs242941
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Asthma attack
|
|
0.010 |
GeneticVariation |
BEFREE |
Thus, CRHR1 gene SNP rs242941 polymorphism is associated with better response to systemic corticosteroid during acute exacerbation of asthma.
|
25712009 |
2015 |
|
rs110402
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
child abuse behavior
|
|
0.030 |
GeneticVariation |
BEFREE |
We then extended our previously reported interaction with both a CRHR1 SNP (rs110402) and TCA haplotype interacting with child abuse to predict current symptoms (N = 1,059; P = 0.0089).
|
20029939 |
2010 |
|
rs110402
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
child abuse behavior
|
|
0.030 |
GeneticVariation |
BEFREE |
While GSK561679 was not superior to placebo overall, it was associated with a significantly stronger symptom reduction in a subset of patients with probable CRF system hyperactivity, i.e., patients with child abuse and CRHR1 SNP rs110402 GG carriers.
|
30390684 |
2018 |
|
rs110402
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
child abuse behavior
|
|
0.030 |
GeneticVariation |
BEFREE |
This study examined the contributions of a polymorphism of the corticotropin-releasing hormone receptor type I (CRHR1) gene (rs110402) and a history of child maltreatment--alone and in interaction--to patterns of cortisol reactivity in adolescents.
|
24703172 |
2014 |
|
rs12944712
|
CRHR1;LINC02210-CRHR1
|
child abuse behavior
|
|
0.010 |
GeneticVariation |
BEFREE |
FKBP5 (rs1360780) and CRHR1 (rs12944712) polymorphisms significantly interacted with child abuse and adult stress to predict increases in physical health ailments over 3 years.
|
24099078 |
2014 |