|
rs110402
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Anxiety Disorders
|
|
0.030 |
GeneticVariation |
BEFREE |
It has been proposed that the common intronic CRHR1 SNP rs110402 is associated with anxiety and cortisol response patterns and plays a key role in vulnerability to certain mental disorders.
|
30447186 |
2019 |
|
rs110402
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Major Depressive Disorder
|
|
0.030 |
GeneticVariation |
BEFREE |
Results from healthy controls and a preliminary sample of MDD participants show that CRHR1 single nucleotide polymorphism rs110402 moderates neural responses to emotional stimuli, suggesting a potential mechanism of vulnerability for the development of MDD.
|
22378896 |
2012 |
|
rs110402
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Major Depressive Disorder
|
|
0.030 |
GeneticVariation |
BEFREE |
The T-A haplotype consisting of rs7209436 and rs110402 in CRHR1 was positively associated with MDD.
|
22467522 |
2012 |
|
rs110402
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Anxiety Disorders
|
|
0.030 |
GeneticVariation |
BEFREE |
Here, we provide clinical translation for the importance of these molecular interactions using an imaging genetics strategy to examine whether interactions between genetic polymorphisms associated with differential anandamide (FAAH rs324420) and CRF1 (CRHR1 rs110402) signaling modulate amygdala function and anxiety disorder diagnosis.
|
26923505 |
2016 |
|
rs110402
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
child abuse behavior
|
|
0.030 |
GeneticVariation |
BEFREE |
We then extended our previously reported interaction with both a CRHR1 SNP (rs110402) and TCA haplotype interacting with child abuse to predict current symptoms (N = 1,059; P = 0.0089).
|
20029939 |
2010 |
|
rs110402
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
child abuse behavior
|
|
0.030 |
GeneticVariation |
BEFREE |
While GSK561679 was not superior to placebo overall, it was associated with a significantly stronger symptom reduction in a subset of patients with probable CRF system hyperactivity, i.e., patients with child abuse and CRHR1 SNP rs110402 GG carriers.
|
30390684 |
2018 |
|
rs110402
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Anxiety Disorders
|
|
0.030 |
GeneticVariation |
BEFREE |
We observed interactions between trait anxiety and rs7209436 and rs110402 in CRHR1 in association with baseline cortisol (p LRT = 0.0272 and p LRT = 0.0483, respectively).
|
23274505 |
2013 |
|
rs110402
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Major Depressive Disorder
|
|
0.030 |
GeneticVariation |
BEFREE |
The association of the CRHR1 SNPs rs12944712, rs110402, and rs878886 with MDD was evaluated in 629 Brazilian adults of European descent recruited from the general population [180 (28.6%) with lifetime MDD].
|
27544317 |
2016 |
|
rs110402
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
child abuse behavior
|
|
0.030 |
GeneticVariation |
BEFREE |
This study examined the contributions of a polymorphism of the corticotropin-releasing hormone receptor type I (CRHR1) gene (rs110402) and a history of child maltreatment--alone and in interaction--to patterns of cortisol reactivity in adolescents.
|
24703172 |
2014 |
|
rs242939
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Major Depressive Disorder
|
|
0.030 |
GeneticVariation |
BEFREE |
CRHR1 gene (rs1876828, rs242939 and rs242941) and BDNF gene (rs6265) were identified in the samples of patients diagnosed with recurrent MDD and matched controls.
|
22194899 |
2011 |
|
rs242939
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Major Depressive Disorder
|
|
0.030 |
GeneticVariation |
BEFREE |
In this study, we show a significant increase in the G-allele (rs242939) of the CRHR1 gene in the recurrent MDD group compared with the control group, and an overrepresentation of G-G-T hyplotype of the CRHR1 gene in recurrent MDD.
|
23529111 |
2013 |
|
rs242939
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Major Depressive Disorder
|
|
0.030 |
GeneticVariation |
BEFREE |
In this study, we tested whether the polymorphisms of three sites (rs1876828, rs242939 and rs242941) in corticotropin-releasing hormone receptor1 (CRHR1) gene are related to 6 weeks fluoxetine antidepressant effect in 127 Han Chinese patients with MDD.
|
17258395 |
2007 |
|
rs242941
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Major Depressive Disorder
|
|
0.030 |
GeneticVariation |
BEFREE |
To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV.
|
23157339 |
2013 |
|
rs242941
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Major Depressive Disorder
|
|
0.030 |
GeneticVariation |
BEFREE |
CRHR1 gene (rs1876828, rs242939 and rs242941) and BDNF gene (rs6265) were identified in the samples of patients diagnosed with recurrent MDD and matched controls.
|
22194899 |
2011 |
|
rs242941
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Major Depressive Disorder
|
|
0.030 |
GeneticVariation |
BEFREE |
The results show that the rs242941 G/G genotype and homozygous GAG haplotype of the three single-nucleotide polymorphisms (SNPs) are associated with fluoxetine therapeutic response in MDD patients of high-anxiety (HA).
|
17258395 |
2007 |
|
rs242941
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Depressive disorder
|
|
0.030 |
GeneticVariation |
BEFREE |
The BclI and ER22/23EK single nucleotide polymorphisms (SNPs) of the GR and the haplotype-tagged rs1876828, rs242939 and rs242941 SNPs of the CRHR1 associated with genetic risk to depressive disorders were genotyped.
|
23726670 |
2013 |
|
rs242941
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Depressive disorder
|
|
0.030 |
GeneticVariation |
BEFREE |
When all subjects were grouped based on family history of mental illness, there was a statistically significant association of CRHR1 rs242941 with family history regardless of depression status (P = 0.043).
|
26518448 |
2015 |
|
rs242941
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Depressive disorder
|
|
0.030 |
GeneticVariation |
BEFREE |
To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV.
|
23157339 |
2013 |
|
rs7209436
|
CRHR1;LINC02210-CRHR1
|
Irritable Bowel Syndrome
|
|
0.030 |
GeneticVariation |
BEFREE |
Previously, we reported that a CRHR1 gene polymorphism (rs110402, rs242924, and rs7209436) and haplotypes were associated with IBS.
|
26808377 |
2016 |
|
rs7209436
|
CRHR1;LINC02210-CRHR1
|
Irritable Bowel Syndrome
|
|
0.030 |
GeneticVariation |
BEFREE |
The TT genotype of rs7209436 (P = 0.01) and rs242924 (P = 0.02) was significantly more common in patients with IBS than in controls.
|
22957021 |
2012 |
|
rs7209436
|
CRHR1;LINC02210-CRHR1
|
Irritable Bowel Syndrome
|
|
0.030 |
GeneticVariation |
BEFREE |
Three CRH-R1 SNPS (rs110402, rs242924, and rs7209436) were genotyped using salivary DNA from IBS and healthy control subjects (HCs).
|
27497153 |
2016 |
|
rs110402
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Mental disorders
|
|
0.020 |
GeneticVariation |
BEFREE |
An interaction of CRHR1 rs110402 and CRHBP rs3811939 predicts high risk of comorbid AUD in schizophrenic patients (odds ratio = 2.27; 95% confidence interval, 1.56-3.30; P < .001) as well as psychiatric disease controls (odds ratio = 4.02; 95% confidence interval, 0.95-17.05; P = .06) and leads to the highest CRHR1/CRHBP messenger RNA ratio (P = .02; dysbalanced stress axis).
|
21810631 |
2011 |
|
rs110402
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Mental disorders
|
|
0.020 |
GeneticVariation |
BEFREE |
It has been proposed that the common intronic CRHR1 SNP rs110402 is associated with anxiety and cortisol response patterns and plays a key role in vulnerability to certain mental disorders.
|
30447186 |
2019 |
|
rs110402
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Anxiety
|
|
0.020 |
GeneticVariation |
BEFREE |
It has been proposed that the common intronic CRHR1 SNP rs110402 is associated with anxiety and cortisol response patterns and plays a key role in vulnerability to certain mental disorders.
|
30447186 |
2019 |
|
rs110402
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Anxiety
|
|
0.020 |
GeneticVariation |
BEFREE |
We observed interactions between trait anxiety and rs7209436 and rs110402 in CRHR1 in association with baseline cortisol (p LRT = 0.0272 and p LRT = 0.0483, respectively).
|
23274505 |
2013 |