GCKR, glucokinase regulator, 2646

N. diseases: 136; N. variants: 23
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1260326
rs1260326
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C3150714
Disease:
FASTING PLASMA GLUCOSE LEVEL QUANTITATIVE TRAIT LOCUS 5 		C 0.700 GeneticVariation CLINVAR
dbSNP: rs780094
rs780094
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.900 GeneticVariation GWASDB Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. 17463246 2007
dbSNP: rs780094
rs780094
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0202236
Disease:
Triglycerides measurement 		T 0.800 GeneticVariation GWASCAT Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. 17463246 2007
dbSNP: rs780094
rs780094
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.900 GeneticVariation BEFREE The minor GCKR A-allele of rs780094 is associated with an increased level of fasting serum triacylglycerol (p = 6 x 10(-14)), impaired fasting (p = 0.001) and OGTT-related insulin release (p = 3 x 10(-6)), reduced homeostasis model assessment of insulin resistance (p = 0.0004), WHO-defined dyslipidaemia (p = 6 x 10(-9)) and a modestly decreased risk of type 2 diabetes (p = 0.01). 18008060 2008
dbSNP: rs780094
rs780094
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0242339
Disease:
Dyslipidemias 		0.030 GeneticVariation BEFREE The minor GCKR A-allele of rs780094 is associated with an increased level of fasting serum triacylglycerol (p = 6 x 10(-14)), impaired fasting (p = 0.001) and OGTT-related insulin release (p = 3 x 10(-6)), reduced homeostasis model assessment of insulin resistance (p = 0.0004), WHO-defined dyslipidaemia (p = 6 x 10(-9)) and a modestly decreased risk of type 2 diabetes (p = 0.01). 18008060 2008
dbSNP: rs780094
rs780094
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0202117
Disease:
Low density lipoprotein cholesterol measurement 		T 0.800 GeneticVariation GWASDB Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia. 18179892 2008
dbSNP: rs780094
rs780094
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0202117
Disease:
Low density lipoprotein cholesterol measurement 		T 0.800 GeneticVariation GWASCAT Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia. 18179892 2008
dbSNP: rs780094
rs780094
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0428474
Disease:
Serum LDL cholesterol measurement 		T 0.700 GeneticVariation GWASDB Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia. 18179892 2008
dbSNP: rs780094
rs780094
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0202236
Disease:
Triglycerides measurement 		T 0.800 GeneticVariation GWASDB Newly identified loci that influence lipid concentrations and risk of coronary artery disease. 18193043 2008
dbSNP: rs780094
rs780094
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0202236
Disease:
Triglycerides measurement 		T 0.800 GeneticVariation GWASCAT Newly identified loci that influence lipid concentrations and risk of coronary artery disease. 18193043 2008
dbSNP: rs780094
rs780094
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0202236
Disease:
Triglycerides measurement 		T 0.800 GeneticVariation GWASDB Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. 18193044 2008
dbSNP: rs780094
rs780094
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0202236
Disease:
Triglycerides measurement 		T 0.800 GeneticVariation GWASCAT Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. 18193044 2008
dbSNP: rs780094
rs780094
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0201657
Disease:
C-reactive protein measurement 		A 0.800 GeneticVariation GWASDB Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study. 18439548 2008
dbSNP: rs780094
rs780094
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0201657
Disease:
C-reactive protein measurement 		A 0.800 GeneticVariation GWASCAT Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study. 18439548 2008
dbSNP: rs1260326
rs1260326
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0202236
Disease:
Triglycerides measurement 		0.800 GeneticVariation GWASCAT Common genetic variation near MC4R is associated with waist circumference and insulin resistance. 18454146 2008
dbSNP: rs1260326
rs1260326
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0392885
Disease:
High density lipoprotein measurement 		0.700 GeneticVariation GWASDB Common genetic variation near MC4R is associated with waist circumference and insulin resistance. 18454146 2008
dbSNP: rs1260326
rs1260326
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.770 GeneticVariation BEFREE The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population. 18556336 2008
dbSNP: rs1260326
rs1260326
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0242339
Disease:
Dyslipidemias 		0.030 GeneticVariation BEFREE We evaluated, in a general French population, the contribution of the GCKR rs1260326-P446L polymorphism to quantitative metabolic parameters and to dyslipidemia and hyperglycemia risk. 18556336 2008
dbSNP: rs1260326
rs1260326
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0020456
Disease:
Hyperglycemia 		0.010 GeneticVariation BEFREE Moreover, an additive effect of GCKR rs1260326(T) and GCK (-30G) alleles conferred lower fasting glycemia (P = 1 x 10(-13)), insulinemia (P = 5 x 10(-6)), and hyperglycemia risk (P = 1 x 10(-6)). 18556336 2008
dbSNP: rs780094
rs780094
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0010346
Disease:
Crohn Disease 		0.800 GeneticVariation GWASDB Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. 18587394 2008
dbSNP: rs1260326
rs1260326
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0524620
Disease:
Metabolic Syndrome X 		0.040 GeneticVariation BEFREE A polymorphism in the GCKR gene predicted dyslipidaemia (rs1260326, OR 1.15, 95% CI 1.09-1.22, p < 0.00001) but not the metabolic syndrome. 18853134 2008
dbSNP: rs1260326
rs1260326
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0242339
Disease:
Dyslipidemias 		0.030 GeneticVariation BEFREE A polymorphism in the GCKR gene predicted dyslipidaemia (rs1260326, OR 1.15, 95% CI 1.09-1.22, p < 0.00001) but not the metabolic syndrome. 18853134 2008
dbSNP: rs1260326
rs1260326
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0202236
Disease:
Triglycerides measurement 		T 0.800 GeneticVariation GWASCAT Common variants at 30 loci contribute to polygenic dyslipidemia. 19060906 2009
dbSNP: rs1260326
rs1260326
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0202236
Disease:
Triglycerides measurement 		T 0.800 GeneticVariation GWASDB Common variants at 30 loci contribute to polygenic dyslipidemia. 19060906 2009
dbSNP: rs1260326
rs1260326
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0495706
Disease:
elevated blood glucose level 		A 0.800 GeneticVariation GWASDB Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. 19060910 2009