GCKR, glucokinase regulator, 2646

N. diseases: 136; N. variants: 23
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs11681351
rs11681351
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0003868
Disease:
Arthritis, Gouty 		0.700 GeneticVariation GWASDB Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. 23263486 2013
dbSNP: rs11681351
rs11681351
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0018099
Disease:
Gout 		0.700 GeneticVariation GWASDB Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. 23263486 2013
dbSNP: rs11681351
rs11681351
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0202236
Disease:
Triglycerides measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs11681351
rs11681351
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0003868
Disease:
Arthritis, Gouty 		0.700 GeneticVariation GWASDB Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors. 20884846 2010
dbSNP: rs11681351
rs11681351
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0018099
Disease:
Gout 		0.700 GeneticVariation GWASDB Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors. 20884846 2010
dbSNP: rs1260320
rs1260320
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0018099
Disease:
Gout 		0.700 GeneticVariation GWASDB Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors. 20884846 2010
dbSNP: rs1260320
rs1260320
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0003868
Disease:
Arthritis, Gouty 		0.700 GeneticVariation GWASDB Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. 23263486 2013
dbSNP: rs1260320
rs1260320
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0003868
Disease:
Arthritis, Gouty 		0.700 GeneticVariation GWASDB Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors. 20884846 2010
dbSNP: rs1260320
rs1260320
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0018099
Disease:
Gout 		0.700 GeneticVariation GWASDB Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. 23263486 2013
dbSNP: rs1260326
rs1260326
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0020557
Disease:
Hypertriglyceridemia 		T 0.820 GeneticVariation GWASDB Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia. 20657596 2010
dbSNP: rs1260326
rs1260326
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0020557
Disease:
Hypertriglyceridemia 		0.820 GeneticVariation BEFREE Recently, the single nucleotide polymorphism (SNP) identified as rs1260326, in the glucokinase regulatory protein (GCKR), was associated with hypertriglyceridemia in adults. 22105854 2012
dbSNP: rs1260326
rs1260326
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0020557
Disease:
Hypertriglyceridemia 		0.820 GeneticVariation GWASDB Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci. 23505323 2013
dbSNP: rs1260326
rs1260326
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0020557
Disease:
Hypertriglyceridemia 		T 0.820 GeneticVariation GWASCAT Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia. 20657596 2010
dbSNP: rs1260326
rs1260326
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0020557
Disease:
Hypertriglyceridemia 		0.820 GeneticVariation BEFREE Once demographics, medication use and baseline adiposity, and fitness were accounted for, ILI did not modify the baseline association of GCKR-Leu446Pro with elevated triglycerides (β±SE=0.067±0.013, P=1.5×10(-7) and β±SE=0.052±0.015, P=5×10(-4)) or with elevated CRP (β±SE=0.136±0.034, P=5.1×10(-5)and β±SE=0.903±0.038, P=0.015) in the overall sample and Non-Hispanic Whites, respectively. 26578543 2016
dbSNP: rs1260326
rs1260326
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0202236
Disease:
Triglycerides measurement 		T 0.800 GeneticVariation GWASCAT The impact of low-frequency and rare variants on lipid levels. 25961943 2015
dbSNP: rs1260326
rs1260326
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0202239
Disease:
Uric acid measurement (procedure) 		0.800 GeneticVariation GWASDB Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. 19503597 2009
dbSNP: rs1260326
rs1260326
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0495706
Disease:
elevated blood glucose level 		A 0.800 GeneticVariation GWASDB Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. 19060910 2009
dbSNP: rs1260326
rs1260326
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0202239
Disease:
Uric acid measurement (procedure) 		T 0.800 GeneticVariation GWASCAT Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels. 31578528 2019
dbSNP: rs1260326
rs1260326
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0003868
Disease:
Arthritis, Gouty 		0.800 GeneticVariation GWASDB Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele. 21768215 2011
dbSNP: rs1260326
rs1260326
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0018099
Disease:
Gout 		T 0.800 GeneticVariation GWASCAT GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes. 27899376 2017
dbSNP: rs1260326
rs1260326
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0202236
Disease:
Triglycerides measurement 		T 0.800 GeneticVariation GWASCAT Bivariate genome-wide association study identifies novel pleiotropic loci for lipids and inflammation. 27286809 2016
dbSNP: rs1260326
rs1260326
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0523465
Disease:
Serum albumin measurement 		T 0.800 GeneticVariation GWASDB Discovery and fine mapping of serum protein loci through transethnic meta-analysis. 23022100 2012
dbSNP: rs1260326
rs1260326
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0003868
Disease:
Arthritis, Gouty 		0.800 GeneticVariation GWASCAT Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels. 31578528 2019
dbSNP: rs1260326
rs1260326
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0337438
Disease:
Glucose measurement 		0.800 GeneticVariation GWASCAT Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases. 29403010 2018
dbSNP: rs1260326
rs1260326
Entrez Id: 2646
Gene Symbol: GCKR
GCKR
CUI: C0017654
Disease:
Glomerular Filtration Rate 		0.800 GeneticVariation GWASDB Using multiple measures for quantitative trait association analyses: application to estimated glomerular filtration rate. 23535967 2013