|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Coronary heart disease
|
|
0.020 |
GeneticVariation |
BEFREE |
We conducted a three-stage case-control study of CHD in Chinese to test our hypothesis by genotyping miR-196a2 rs11614913 and three other pre-miRNA SNPs (miR-146a rs2910164, miR-149 rs2292832, and miR-499 rs3746444) in 1,324 CHD cases and 1,783 non-CHD controls.
|
19514064 |
2009 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Anthracosis
|
|
0.010 |
GeneticVariation |
BEFREE |
These results suggest that miR-149 rs2292832 polymorphism is involved in susceptibility to developing CWP.
|
19881472 |
2010 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Squamous cell carcinoma of the head and neck
|
|
0.010 |
GeneticVariation |
BEFREE |
The authors genotyped 4 common polymorphisms in pre-miRNAs: Homo sapiens miRNA 146a (hsa-mir-146a) (reference SNP 2910164 [rs2910164]; guanine to cytosine [G→C]), hsa-mir-149 (rs2292832; guanine to thymine [G→T]), hsa-mir-196a2 (rs11614913; C→T), and hsa-mir-499 (rs3746444; adenine to guanine [A→G]) in 1109 patients with SCCHN (cases) and in 1130 cancer-free patients (controls) in a non-Hispanic white population that was frequency-matched by age and sex.
|
20549817 |
2010 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Asthma
|
|
0.020 |
GeneticVariation |
BEFREE |
Our data indicate that rs2910164G/C and rs2292832C/T may play a role in the development of asthma.
|
21663520 |
2011 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation |
BEFREE |
Here, we evaluated 101 paired samples (cancer and normal tissues) from non-small cell lung carcinoma (NSCLC) patients to study the genotype distribution of single nucleotide polymorphisms (SNPs) in miR-146a (rs2910164 C-G), miR-149 (rs2292832 C-T), miR-196a2 (rs11614913 C-T) and miR-499 (rs3746444 G-A) and their influence on the expression of respective miRNAs.
|
21902575 |
2011 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation |
BEFREE |
Here, we evaluated 101 paired samples (cancer and normal tissues) from non-small cell lung carcinoma (NSCLC) patients to study the genotype distribution of single nucleotide polymorphisms (SNPs) in miR-146a (rs2910164 C-G), miR-149 (rs2292832 C-T), miR-196a2 (rs11614913 C-T) and miR-499 (rs3746444 G-A) and their influence on the expression of respective miRNAs.
|
21902575 |
2011 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Non-Small Cell Lung Carcinoma
|
|
0.020 |
GeneticVariation |
BEFREE |
Here, we evaluated 101 paired samples (cancer and normal tissues) from non-small cell lung carcinoma (NSCLC) patients to study the genotype distribution of single nucleotide polymorphisms (SNPs) in miR-146a (rs2910164 C-G), miR-149 (rs2292832 C-T), miR-196a2 (rs11614913 C-T) and miR-499 (rs3746444 G-A) and their influence on the expression of respective miRNAs.
|
21902575 |
2011 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Colorectal Carcinoma
|
|
0.080 |
GeneticVariation |
BEFREE |
The SNPs of rs2292832 and rs2043556 might be able to modify the susceptibility to male gastric and colorectal cancers, respectively.
|
21976437 |
2012 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Malignant neoplasm of gastrointestinal tract
|
|
0.030 |
GeneticVariation |
BEFREE |
To explore the associations of SNPs within hsa-miR-605 (rs2043556) and hsa-miR-149 (rs2292832) and lifestyle-related factors with gastrointestinal cancer, a case-control study including 762 cases and 757 controls was conducted.
|
21976437 |
2012 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Malignant neoplasm of colon and/or rectum
|
|
0.030 |
GeneticVariation |
BEFREE |
Marginally significant associations were found both for hsa-miR-149 rs2292832 with gastric cancer risk (TC + CC vs. TT, OR = 0.68, 95% CI: 0.44-1.04) and for hsa-miR-605 rs2043556 with colorectal cancer risk (AG + GG vs. AA, OR = 0.70, 95% CI: 0.48-1.02) in males.
|
21976437 |
2012 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Breast Carcinoma
|
|
0.050 |
GeneticVariation |
BEFREE |
To explore the relevance of miRNA polymorphisms and female physiological characteristics to breast cancer risk, SNPs located within hsa-miR-605 (rs2043556), hsa-miR-149 (rs2292832), hsa-miR-27a (rs895819), hsa-miR-196a-2 (rs11614913) and hsa-miR-618 (rs2682818) were selected, and their associations with breast cancer risk were analysed.
|
22074121 |
2012 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Malignant neoplasm of breast
|
|
0.050 |
GeneticVariation |
BEFREE |
To explore the relevance of miRNA polymorphisms and female physiological characteristics to breast cancer risk, SNPs located within hsa-miR-605 (rs2043556), hsa-miR-149 (rs2292832), hsa-miR-27a (rs895819), hsa-miR-196a-2 (rs11614913) and hsa-miR-618 (rs2682818) were selected, and their associations with breast cancer risk were analysed.
|
22074121 |
2012 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Colorectal Carcinoma
|
|
0.080 |
GeneticVariation |
BEFREE |
Although recent studies focused on various diseases that harbor the miR-146aC>G (rs2910164), 149C>T (rs2292832), 196a2C>T (rs11614913), and 499A>G (rs3746444) polymorphisms, the role of miRNA genetic variants in colorectal cancer is still unknown.
|
22161766 |
2012 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Malignant neoplasm of colon and/or rectum
|
|
0.030 |
GeneticVariation |
BEFREE |
Although recent studies focused on various diseases that harbor the miR-146aC>G (rs2910164), 149C>T (rs2292832), 196a2C>T (rs11614913), and 499A>G (rs3746444) polymorphisms, the role of miRNA genetic variants in colorectal cancer is still unknown.
|
22161766 |
2012 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation |
BEFREE |
The association between four genetic variants in microRNAs (rs11614913, rs2910164, rs3746444, rs2292832) and cancer risk: evidence from published studies.
|
23155448 |
2012 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation |
BEFREE |
The association between four genetic variants in microRNAs (rs11614913, rs2910164, rs3746444, rs2292832) and cancer risk: evidence from published studies.
|
23155448 |
2012 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Squamous cell carcinoma of oropharynx
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that statistically significant associations with HPV16-positive SCCOP and survival were found for hsa-mir-146a rs2910164 and hsa-mir-196a2 rs11614913, while such similar associations were not observed for hsa-mir-149 rs2292832 and hsa-mir499 rs3746444.
|
23219900 |
2013 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation |
BEFREE |
The present study was aimed to investigate the association between four highly studied miRNA polymorphisms (mir-146a rs2910164, mir-196a2 rs11614913, mir-149 rs2292832 and mir-499 rs3746444) and cancer risk by using a two-sided meta-analytic approach.
|
23226435 |
2012 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation |
BEFREE |
The present study was aimed to investigate the association between four highly studied miRNA polymorphisms (mir-146a rs2910164, mir-196a2 rs11614913, mir-149 rs2292832 and mir-499 rs3746444) and cancer risk by using a two-sided meta-analytic approach.
|
23226435 |
2012 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Non-Small Cell Lung Carcinoma
|
|
0.020 |
GeneticVariation |
BEFREE |
These results suggest that miR-149 and miR-196a may be involved in the pathogenesis of NSCLC, and that rs2292832 and rs11614913 can be used as prognostic markers for patients with surgically resected early-stage NSCLC.
|
23470291 |
2013 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
stage, non-small cell lung cancer
|
|
0.010 |
GeneticVariation |
BEFREE |
To test this hypothesis, we evaluated the effects of four SNPs in pre-miRNAs (pre-miR-146a rs2910164, pre-miR-149 rs2292832, pre-miR-196a rs11614913, and pre-miR-499 rs3746444) on the survival outcomes of patients with early-stage non-small-cell lung cancer (NSCLC).
|
23470291 |
2013 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Malignant Neoplasms
|
|
0.100 |
GeneticVariation |
BEFREE |
For the rs2292832 polymorphism, the results showed no significant risk association in both overall pooled analysis and subgroup of cancer types, smoking status, gender and tea drinking status in the Chinese population.
|
23725137 |
2013 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Primary malignant neoplasm
|
|
0.100 |
GeneticVariation |
BEFREE |
For the rs2292832 polymorphism, the results showed no significant risk association in both overall pooled analysis and subgroup of cancer types, smoking status, gender and tea drinking status in the Chinese population.
|
23725137 |
2013 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Colorectal Carcinoma
|
|
0.080 |
GeneticVariation |
BEFREE |
We genotyped four common polymorphisms (i.e., rs11614913, rs3746444, rs2910164, and rs2292832) in pre-miRNAs of 353 CRC patients and 540 healthy controls to investigate the association between the SNPs and the risk of CRC using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay.
|
23728616 |
2013 |
|
rs2292832
|
GPC1;MIR149;LOC100130449
|
Malignant neoplasm of breast
|
|
0.050 |
GeneticVariation |
BEFREE |
However, for the miR-146a rs2910164 (G>C), miR-149 rs2292832 (G>T), miR-373 rs12983273 (C>T), and miR-423 rs6505162 (C>A) polymorphisms, we failed to find any significant association with the risk of breast cancer in any genetic model.
|
23982873 |
2014 |