|
rs987870
|
HLA-DPA1;HLA-DPB1
|
Asthma
|
|
0.810 |
GeneticVariation |
BEFREE |
SNP rs987870, located between HLA-DPA1 and HLA-DPB1, was consistently associated with pediatric asthma in 3 independent populations (P(combined) = 2.3×10(-10), odds ratio [OR] = 1.40).
|
21814517 |
2011 |
|
rs987870
|
HLA-DPA1;HLA-DPB1
|
Asthma
|
C |
0.810 |
GeneticVariation |
GWASCAT |
SNP rs987870, located between HLA-DPA1 and HLA-DPB1, was consistently associated with pediatric asthma in 3 independent populations (P(combined) = 2.3×10(-10), odds ratio [OR] = 1.40).
|
21814517 |
2011 |
|
rs987870
|
HLA-DPA1;HLA-DPB1
|
Asthma
|
C |
0.810 |
GeneticVariation |
GWASDB |
SNP rs987870, located between HLA-DPA1 and HLA-DPB1, was consistently associated with pediatric asthma in 3 independent populations (P(combined) = 2.3×10(-10), odds ratio [OR] = 1.40).
|
21814517 |
2011 |
|
rs987870
|
HLA-DPA1;HLA-DPB1
|
Systemic Scleroderma
|
|
0.800 |
GeneticVariation |
GWASDB |
Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.
|
21779181 |
2011 |
|
rs987870
|
HLA-DPA1;HLA-DPB1
|
Systemic Scleroderma
|
|
0.800 |
GeneticVariation |
GWASCAT |
Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.
|
21779181 |
2011 |
|
rs3077
|
HLA-DPA1
|
Hepatitis B, Chronic
|
|
0.760 |
GeneticVariation |
BEFREE |
Single nucleotide polymorphisms (SNPs) in HLA-DP (rs9277535 and rs3077) and HLA-DQ (rs2856718 and rs7453920) have been repeatedly associated with chronic hepatitis B and spontaneous HBV clearance.
|
28882445 |
2017 |
|
rs3077
|
HLA-DPA1
|
Hepatitis B, Chronic
|
|
0.760 |
GeneticVariation |
BEFREE |
In genome-wide association studies (GWAS), the human leukocyte antigen (HLA) gene polymorphisms rs3077 and rs9277535 were identified to be associated with chronic hepatitis B. HLA genes have been linked to immune response to infectious agents.
|
28119119 |
2017 |
|
rs3077
|
HLA-DPA1
|
Hepatitis B, Chronic
|
A |
0.760 |
GeneticVariation |
GWASCAT |
Genetic variants in five novel loci including CFB and CD40 predispose to chronic hepatitis B.
|
25802187 |
2015 |
|
rs3077
|
HLA-DPA1
|
Hepatitis B, Chronic
|
|
0.760 |
GeneticVariation |
BEFREE |
Of these variants, SNPs rs3077 and rs9277535 in HLA-DP on chromosome 6 show the strongest evidence for association with CHBVI and with viral clearance.
|
24846544 |
2014 |
|
rs3077
|
HLA-DPA1
|
Hepatitis B, Chronic
|
|
0.760 |
GeneticVariation |
GWASCAT |
A genome-wide association study identified new variants associated with the risk of chronic hepatitis B.
|
23760081 |
2013 |
|
rs3077
|
HLA-DPA1
|
Hepatitis B, Chronic
|
|
0.760 |
GeneticVariation |
BEFREE |
We also found that the HLA-DPA1 and HLA-DPB1 genes were significantly associated with protective effects against chronic hepatitis B (CHB) in Japanese, Korean and other Asian populations, including Chinese and Thai individuals (P(meta) = 4.40×10⁻¹⁹ for rs3077 and P(meta) = 1.28×10⁻¹⁵ for rs9277542).
|
22737229 |
2012 |
|
rs3077
|
HLA-DPA1
|
Hepatitis B, Chronic
|
|
0.760 |
GeneticVariation |
BEFREE |
A genome-wide association study identified single nucleotide polymorphisms (SNPs) rs3077 and rs9277535 located in the 3' untranslated regions of human leukocyte antigen (HLA) class II genes HLA-DPA1 and HLA-DPB1, respectively, as the independent variants most strongly associated with chronic hepatitis B.
|
21346778 |
2011 |
|
rs3077
|
HLA-DPA1
|
Hepatitis B, Chronic
|
|
0.760 |
GeneticVariation |
BEFREE |
Chronic hepatitis B susceptibility loci in HLA-DP region (rs3077 and rs9277535) identified by genome-wide scan in Japanese population were validated in Chinese population.
|
21408128 |
2011 |
|
rs3077
|
HLA-DPA1
|
Liver carcinoma
|
|
0.740 |
GeneticVariation |
BEFREE |
Our analysis indicated a significant</span> association of rs3077 and rs9277535 with HCC susceptibility, suggesting that rs3077 might act beneficially against HCC susceptibility (A vs G: OR = 0.884, 95%CI = 0.803-0.973, P = 0.012; GA vs GG: OR = 0.842, 95%CI = 0.733-0.967, P = 0.015; AA+GA vs GG: OR = 0.848, 95%CI = 0.744-0.968, P = 0.014), and that rs9277535 might promote HCC susceptibility (AA vs GA: OR = 1.202, 95%CI = 1.011-1.428, P = 0.037).
|
26634522 |
2015 |
|
rs3077
|
HLA-DPA1
|
Liver carcinoma
|
|
0.740 |
GeneticVariation |
BEFREE |
However, the experiment showed that HLA-DP rs3077, rs9277535 and rs7453920 did not associate with HCC development (dominant model, rs3077, OR = 0.86, 95%CI = 0.62-1.18; rs9277535, OR = 0.94, 95%CI = 0.68-1.30; rs7453920, OR = 0.75, 95%CI = 0.44-1.27).
|
25365208 |
2014 |
|
rs3077
|
HLA-DPA1
|
Liver carcinoma
|
|
0.740 |
GeneticVariation |
GWASDB |
Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma.
|
23242368 |
2013 |
|
rs3077
|
HLA-DPA1
|
Liver carcinoma
|
|
0.740 |
GeneticVariation |
BEFREE |
In addition, HLA-DP rs3077 showed an approaching significant effect on susceptibility to HBV persistent infection and HCC development when considering multiple testing adjustments.
|
22105689 |
2012 |
|
rs3077
|
HLA-DPA1
|
Liver carcinoma
|
|
0.740 |
GeneticVariation |
BEFREE |
However, rs3077 was not associated with the development of cirrhosis or hepatocellular carcinoma.
|
21402545 |
2011 |
|
rs1042169
|
HLA-DPA1;HLA-DPB1
|
Hepatitis B
|
|
0.710 |
GeneticVariation |
BEFREE |
Utilizing PCR sequencing, we verified the relationship of the top 3 most significant SNPs (rs1042169, rs9277355 and rs9277356) from the GWAS and genotypes of HLA-DPB1 with the HB vaccine response in Korean infants who received a scheduled vaccination.
|
31243853 |
2019 |
|
rs3135021
|
HLA-DPA1;HLA-DPB1
|
Hepatitis B
|
|
0.710 |
GeneticVariation |
BEFREE |
By contrast, the HLA-DPB1 rs3135021 variant was not associated with the outcome of HBV infection, including susceptibility, spontaneously resolved, or disease progression.
|
27051043 |
2016 |
|
rs7750458
|
HLA-DPA1;HLA-DPB1
|
Dermatomyositis
|
A |
0.710 |
GeneticVariation |
GWASCAT |
Variation at HLA-DPB1 is associated with dermatomyositis in Chinese population.
|
27153935 |
2016 |
|
rs7750458
|
HLA-DPA1;HLA-DPB1
|
Dermatomyositis
|
|
0.710 |
GeneticVariation |
BEFREE |
We investigated whether the three SNP (rs7750458, rs9501251 and rs9500928) at 6p21.32 in the HLA-DPB1 gene were significantly associated with DM (P < 5 × 10<sup>-8</sup> ) and identified two susceptibility loci at 7q34 (PIP, rs9986765, P = 7.45 × 10<sup>-7</sup> , odds ratio [OR] = 2.71) and 10q24.2 (CPN1, rs3750716, P = 9.04 × 10<sup>-7</sup> , OR = 4.39) with suggestive evidence.
|
27153935 |
2016 |
|
rs7770370
|
HLA-DPA1;HLA-DPB1
|
Hepatitis B
|
|
0.710 |
GeneticVariation |
BEFREE |
Our results showed that rs7770370 was the most significant genetic factor of response to HB booster.
|
25389088 |
2015 |
|
rs1042169
|
HLA-DPA1;HLA-DPB1
|
Hepatitis B
|
|
0.710 |
GeneticVariation |
GWASDB |
A genome-wide association study identified new variants associated with the risk of chronic hepatitis B.
|
23760081 |
2013 |
|
rs1042169
|
HLA-DPA1;HLA-DPB1
|
Hepatitis B
|
A |
0.710 |
GeneticVariation |
GWASDB |
New loci associated with chronic hepatitis B virus infection in Han Chinese.
|
24162738 |
2013 |