ICAM1, intercellular adhesion molecule 1, 3383

N. diseases: 737; N. variants: 18
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs5498
rs5498
Entrez Id: 3383;3386
Gene Symbol: ICAM1;ICAM4
ICAM1;ICAM4
CUI: C0026769
Disease:
Multiple Sclerosis
0.030 GeneticVariation BEFREE Thus, we conclude that <i>ICAM1</i> rs5498 may not be related to the risk of multiple sclerosis in Caucasian or Asian populations, which still merits further research. 30473535 2018
dbSNP: rs5498
rs5498
Entrez Id: 3383;3386
Gene Symbol: ICAM1;ICAM4
ICAM1;ICAM4
CUI: C0026769
Disease:
Multiple Sclerosis
0.030 GeneticVariation BEFREE Correlation of clinical findings as age at onset, Kurtzke Expanded Disability Status Scale, Multiple Sclerosis Severity Score and progression index with ICAM1 genotypes in MS patients revealed no significant association; however, patients with earlier onset of MS showed slightly higher frequencies of the homozygous G allele at rs5498 in comparison to other genotypes (P = 0.04), suggesting that GG carriers tend to induce MS at an earlier age. 28130760 2017
dbSNP: rs5498
rs5498
Entrez Id: 3383;3386
Gene Symbol: ICAM1;ICAM4
ICAM1;ICAM4
CUI: C0026769
Disease:
Multiple Sclerosis
0.030 GeneticVariation BEFREE Intercellular adhesion molecule-1 K469E polymorphism: study of association with multiple sclerosis. 12590979 2003
dbSNP: rs1799969
rs1799969
Entrez Id: 3383
Gene Symbol: ICAM1
ICAM1
CUI: C0026769
Disease:
Multiple Sclerosis
0.010 GeneticVariation BEFREE The objective of our case-control study was to analyze the association of two functional ICAM1 polymorphisms rs1799969 (or G241R) and rs5498 (or K469E) with susceptibility to MS and evaluate their influence on the age at disease onset, severity, neurological disability and progression rate. 28130760 2017