IRF5, interferon regulatory factor 5, 3663

N. diseases: 226; N. variants: 15
Disease: Lupus Vulgaris ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2004640
rs2004640
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
CUI: C0024131
Disease:
Lupus Vulgaris 		0.010 GeneticVariation BEFREE Although we could not demonstrate susceptibility toward lupus in the presence of IRF5 rs2004640 (G/T) polymorphism, further exploration of the genetic variability of IRF5 may help uncover its pathogenic role in Indian SLE patients. 30168487 2018
dbSNP: rs2070197
rs2070197
Entrez Id: 3663
Gene Symbol: IRF5
IRF5
CUI: C0024131
Disease:
Lupus Vulgaris 		0.010 GeneticVariation BEFREE Importantly, our data suggest that in patients with lupus, the presence of the HLA lupus risk alleles in rs1270942 and rs3131379 increases the odds of also carrying the lupus risk allele in IRF5 (rs2070197) by 17% and 16%, respectively (P = 0.0028 and P = 0.0047, respectively). 21952918 2012