KRAS, KRAS proto-oncogene, GTPase, 3845

N. diseases: 1213; N. variants: 54
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs104886028
rs104886028
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0238462
Disease:
Medullary carcinoma of thyroid 		0.010 GeneticVariation BEFREE Large-scale molecular dynamics simulations were completed for H-RAS wt and H-RAS M72I.Western blot analysis demonstrated that both MAPK and PI3K/Akt pathways were activated in the MTC patient carrying the M72I variant. 23934677 2013
dbSNP: rs104894359
rs104894359
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C1860991
Disease:
NOONAN SYNDROME 3 		0.800 GeneticVariation UNIPROT Noonan syndrome: clinical features, diagnosis, and management guidelines. 20876176 2010
dbSNP: rs104894359
rs104894359
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C3809005
Disease:
CARDIOFACIOCUTANEOUS SYNDROME 2 		0.800 GeneticVariation UNIPROT Germline KRAS mutations cause Noonan syndrome. 16474405 2006
dbSNP: rs104894359
rs104894359
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C1860991
Disease:
NOONAN SYNDROME 3 		0.800 GeneticVariation UNIPROT Germline missense mutations affecting KRAS Isoform B are associated with a severe Noonan syndrome phenotype. 16773572 2006
dbSNP: rs104894359
rs104894359
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C1860991
Disease:
NOONAN SYNDROME 3 		0.800 GeneticVariation UNIPROT Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders. 20949621 2011
dbSNP: rs104894359
rs104894359
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C3809005
Disease:
CARDIOFACIOCUTANEOUS SYNDROME 2 		0.800 GeneticVariation UNIPROT Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome. 16474404 2006
dbSNP: rs104894359
rs104894359
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C1860991
Disease:
NOONAN SYNDROME 3 		0.800 GeneticVariation UNIPROT Expansion of the genotypic and phenotypic spectrum in patients with KRAS germline mutations. 17056636 2007
dbSNP: rs104894359
rs104894359
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C3809005
Disease:
CARDIOFACIOCUTANEOUS SYNDROME 2 		0.800 GeneticVariation UNIPROT Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders. 20949621 2011
dbSNP: rs104894359
rs104894359
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C3809005
Disease:
CARDIOFACIOCUTANEOUS SYNDROME 2 		G 0.800 CausalMutation CLINVAR
dbSNP: rs104894359
rs104894359
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C1860991
Disease:
NOONAN SYNDROME 3 		T 0.800 CausalMutation CLINVAR
dbSNP: rs104894359
rs104894359
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C3809005
Disease:
CARDIOFACIOCUTANEOUS SYNDROME 2 		0.800 GeneticVariation UNIPROT Expansion of the genotypic and phenotypic spectrum in patients with KRAS germline mutations. 17056636 2007
dbSNP: rs104894359
rs104894359
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C1860991
Disease:
NOONAN SYNDROME 3 		0.800 GeneticVariation UNIPROT Further evidence of genetic heterogeneity in Costello syndrome: involvement of the KRAS gene. 17468812 2007
dbSNP: rs104894359
rs104894359
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C3809005
Disease:
CARDIOFACIOCUTANEOUS SYNDROME 2 		0.800 GeneticVariation UNIPROT Two novel germline KRAS mutations: expanding the molecular and clinical phenotype. 21797849 2012
dbSNP: rs104894359
rs104894359
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C1860991
Disease:
NOONAN SYNDROME 3 		0.800 GeneticVariation UNIPROT Germline KRAS mutations cause Noonan syndrome. 16474405 2006
dbSNP: rs104894359
rs104894359
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C1860991
Disease:
NOONAN SYNDROME 3 		0.800 GeneticVariation UNIPROT Craniosynostosis in patients with Noonan syndrome caused by germline KRAS mutations. 19396835 2009
dbSNP: rs104894359
rs104894359
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C1275081
Disease:
Cardio-facio-cutaneous syndrome 		G 0.700 CausalMutation CLINVAR Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome. 16474404 2006
dbSNP: rs104894359
rs104894359
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0028326
Disease:
Noonan Syndrome 		G 0.700 CausalMutation CLINVAR Expansion of the genotypic and phenotypic spectrum in patients with KRAS germline mutations. 17056636 2007
dbSNP: rs104894359
rs104894359
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0028326
Disease:
Noonan Syndrome 		G 0.700 CausalMutation CLINVAR Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders. 20949621 2011
dbSNP: rs104894359
rs104894359
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C1275081
Disease:
Cardio-facio-cutaneous syndrome 		G 0.700 CausalMutation CLINVAR Expansion of the genotypic and phenotypic spectrum in patients with KRAS germline mutations. 17056636 2007
dbSNP: rs104894359
rs104894359
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C1275081
Disease:
Cardio-facio-cutaneous syndrome 		G 0.700 CausalMutation CLINVAR Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders. 20949621 2011
dbSNP: rs104894359
rs104894359
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0028326
Disease:
Noonan Syndrome 		G 0.700 CausalMutation CLINVAR Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome. 16474404 2006
dbSNP: rs104894359
rs104894359
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0028259
Disease:
Nodule 		0.010 GeneticVariation BEFREE Only one point mutation could be found in the N-ras gene codon 61 (Gly to Arg) in a cold adenomatous nodule which was monoclonal. 11531932 2001
dbSNP: rs104894360
rs104894360
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0028326
Disease:
Noonan Syndrome 		A 0.720 CausalMutation CLINVAR We performed detailed biochemical and functional studies of three mutant K-Ras proteins (P34R, D153V, and F156L) found in individuals with Noonan syndrome and cardiofaciocutaneous syndrome. 17875937 2007
dbSNP: rs104894360
rs104894360
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0028326
Disease:
Noonan Syndrome 		A 0.720 CausalMutation CLINVAR Noonan and cardio-facio-cutaneous syndromes: two clinically and genetically overlapping disorders. 18456719 2008
dbSNP: rs104894360
rs104894360
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0028326
Disease:
Noonan Syndrome 		C 0.720 GeneticVariation CLINVAR