rs6010620
|
RTEL1;RTEL1-TNFRSF6B
|
Glioma
|
|
0.900 |
GeneticVariation |
BEFREE |
The current meta-analysis suggested that the rs6010620 polymorphism in the RTEL1 gene might increase risk of glioma.
|
25227808 |
2014 |
rs6010620
|
RTEL1;RTEL1-TNFRSF6B
|
Glioma
|
|
0.900 |
GeneticVariation |
BEFREE |
The rs6010620 (RTEL1), rs4977756 (CDKN2A/B), and rs498872 (PHLDB1) are associated with glioma risk in the Portuguese population and these data may contribute to understanding gliomas etiology.
|
31721021 |
2020 |
rs6010620
|
RTEL1;RTEL1-TNFRSF6B
|
Glioma
|
|
0.900 |
GeneticVariation |
BEFREE |
Results showed that seven hot loci were all associated with increased risk of glioma (rs2736100, OR = 1.28, 95 %CI = 1.23-1.32; rs4295627, OR = 1.34, 95 %CI = 1.21-1.47; rs4977756, OR = 1.24, 95 %CI = 1.20-1.28; rs498872, OR = 1.24, 95 %CI = 1.15-1.33; rs6010620, OR = 1.29, 95 %CI = 1.24-1.35; rs11979158: OR = 1.18, 95 %CI = 1.10-1.25; rs2252586: OR = 1.18, 95 %CI = 1.10-1.25).
|
26243184 |
2016 |
rs6010620
|
RTEL1;RTEL1-TNFRSF6B
|
Glioma
|
|
0.900 |
GeneticVariation |
BEFREE |
Our group identified 5 risk loci for glioma susceptibility (TERT rs2736100, CCDC26 rs4295627, CDKN2A/CDKN2B rs4977756, RTEL1 rs6010620, and PHLDB1 rs498872).
|
20212223 |
2010 |
rs6010620
|
RTEL1;RTEL1-TNFRSF6B
|
Glioma
|
|
0.900 |
GeneticVariation |
BEFREE |
Genome-wide association studies have identified the susceptibility single nucleotide polymorphisms (SNPs) of glioma at chromosome 20q13.33, and the replication study conducted among Chinese Han population also confirmed the susceptibility locus rs6010620 is located in this region.
|
22387365 |
2012 |
rs6010620
|
RTEL1;RTEL1-TNFRSF6B
|
Glioma
|
|
0.900 |
GeneticVariation |
BEFREE |
Overall, there was a significant association between RTEL1 rs6010620 polymorphism and glioma risk in all fo</span>ur genetic models (GG vs. AA: OR=1.87, 95 % CI=1.60-2.18, P heterogeneity=0.552; GA vs. AA: OR=1.30, 95 % CI=1.16-1.46, P heterogeneity=0.495; dominant model-GG+GA vs. AA: OR=1.46, 95 % CI=1.31-1.63, P heterogeneity=0.528; recessive model-GG vs. GA+AA: OR=1.36, 95 % CI=1.27-1.46, P heterogeneity=0.093).
|
24523019 |
2014 |
rs6010620
|
RTEL1;RTEL1-TNFRSF6B
|
Glioma
|
|
0.900 |
GeneticVariation |
BEFREE |
Overall, the authors identified 3 susceptibility loci for glioma risk at 20q13.33 (RTEL1 rs6010620 (P = 2.79 × 10(-6))), 11q23.3 (PHLDB1 rs498872 (P = 3.8 × 10(-6))), and 5p15.33 (TERT rs2736100 (P = 3.69 × 10(-4))) in this study population; these loci were also associated with glioblastoma risk (20q13.33: RTEL1 rs6010620 (P = 3.57 × 10(-7)); 11q23.3: PHLDB1 rs498872 (P = 7.24 × 10(-3)); 5p15.33: TERT rs2736100 and TERT rs2736098 (P = 1.21 × 10(-4) and P = 2.84 × 10(-4), respectively)).
|
21350045 |
2011 |
rs6010620
|
RTEL1;RTEL1-TNFRSF6B
|
Glioma
|
|
0.900 |
GeneticVariation |
BEFREE |
Genome-wide association data have identified common genetic variants at 5p15.33 (rs2736100, TERT), 8q24.21 (rs4295627, CCDC26), 9p21.3 (rs4977756, CDKN2A-CDKN2B), 11q23.3 (rs498872, PHLDB1), and 20q13.33 (rs6010620, RTEL1) as determinants of glioma risk.
|
20462933 |
2010 |
rs6010620
|
RTEL1;RTEL1-TNFRSF6B
|
Glioma
|
|
0.900 |
GeneticVariation |
BEFREE |
After Bonferroni correction for multiple comparisons, only one marker was statistically significantly associated with glioma risk, rs6010620 (ORtrend for the minor (A) allele, 0.39; 95% CI: 0.25-0.61; Bonferroni adjusted ptrend , 1.7 × 10(-4) ).
|
23115063 |
2013 |
rs6010620
|
RTEL1;RTEL1-TNFRSF6B
|
Glioma
|
|
0.900 |
GeneticVariation |
BEFREE |
Four of the five SNPs previously reported by others were statistically significantly associated with increased risk of glioma in our study (rs2736100, rs4295627, rs4977756, and rs6010620); rs498872 was not associated with glioma in our study.
|
23903690 |
2013 |
rs6010620
|
RTEL1;RTEL1-TNFRSF6B
|
Glioma
|
|
0.900 |
GeneticVariation |
BEFREE |
We identified five risk loci for glioma at 5p15.33 (rs2736100, TERT; P = 1.50 x 10(-17)), 8q24.21 (rs4295627, CCDC26; P = 2.34 x 10(-18)), 9p21.3 (rs4977756, CDKN2A-CDKN2B; P = 7.24 x 10(-15)), 20q13.33 (rs6010620, RTEL1; P = 2.52 x 10(-12)) and 11q23.3 (rs498872, PHLDB1; P = 1.07 x 10(-8)).
|
19578367 |
2009 |
rs6010620
|
RTEL1;RTEL1-TNFRSF6B
|
Glioma
|
|
0.900 |
GeneticVariation |
BEFREE |
Case-control analyses stratified into 4 molecular classes (defined by 1p-19q status, IDH mutation, and EGFR amplification) showed an association of rs4295627 and rs498872 with IDH-mutated gliomas (P < 10(-3)) and rs2736100 and rs6010620 with IDH wild-type gliomas (P < 10(-3) and P = .03).
|
23161787 |
2013 |
rs6010620
|
RTEL1;RTEL1-TNFRSF6B
|
Glioma
|
|
0.900 |
GeneticVariation |
BEFREE |
Three of the gene variants (rs4295627, a variant of CCDC26; rs4977756, a variant of CDKN2A and CDKN2B; and rs6010620, a variant of RTEL1) were statistically significantly associated with glioma risk in the present population.
|
21920947 |
2011 |
rs6010620
|
RTEL1;RTEL1-TNFRSF6B
|
Glioma
|
|
0.900 |
GeneticVariation |
BEFREE |
Two single variants, the genotypes of "GG" of rs</span>6010620 and "CC" of rs2297440 (rs6010620</span> and r</span>s2297440) in the RTEL1 gene, together with two haplotypes of GCT and ATT, were identified to be associated with glioma development.
|
23683922 |
2013 |
rs6010620
|
RTEL1;RTEL1-TNFRSF6B
|
Glioma
|
|
0.900 |
GeneticVariation |
BEFREE |
Genome-wide association studies have recently identified single-nucleotide polymorphisms (SNP) in five loci at 5p15.33 (rs2736100, TERT), 8q24.21 (rs4295627, CCDC26), 9p21.3 (rs4977756, CDKN2A/CDKN2B), 20q13.33 (rs6010620, RTEL1), and 11q23.3 (rs498872, PHLDB1) to be associated with glioma risk.
|
20847058 |
2010 |
rs6010620
|
RTEL1;RTEL1-TNFRSF6B
|
Glioma
|
|
0.900 |
GeneticVariation |
BEFREE |
This meta-analysis suggests that the RTEL1 rs6010620 polymorphism may be a risk factor for glioma.
|
25556444 |
2014 |
rs2297440
|
RTEL1;RTEL1-TNFRSF6B
|
Glioma
|
|
0.820 |
GeneticVariation |
BEFREE |
Two single variants, the genotypes of "GG" of rs6010620 and "CC" of rs2297440</span> (rs6010620 and rs2297440) in the RTEL1 gene, together with two haplotypes of GCT and ATT, were identified to be associated with glioma development.
|
23683922 |
2013 |
rs2297440
|
RTEL1;RTEL1-TNFRSF6B
|
Glioma
|
|
0.820 |
GeneticVariation |
BEFREE |
This meta-analysis demonstrates that the RTEL1 rs2297440 polymorphism plays a moderate, but significant role in the risk of gli</span>oma.
|
26939676 |
2016 |
rs6010620
|
RTEL1;RTEL1-TNFRSF6B
|
Dermatitis, Atopic
|
|
0.810 |
GeneticVariation |
BEFREE |
These SNPs (rs11204971, rs3126085, rs7936562, rs712484 and rs6010620) at AD susceptibility genes/loci FLG, 11q13.5 and 20q13.33 were not associated with asthma in this study.
|
22545103 |
2012 |
rs2297440
|
RTEL1;RTEL1-TNFRSF6B
|
Glioblastoma Multiforme
|
|
0.730 |
GeneticVariation |
BEFREE |
Using the χ(2) test, we found that rs2297440 and rs6010620 in RTEL1 increased risk of GBM.
|
26156397 |
2015 |
rs2297440
|
RTEL1;RTEL1-TNFRSF6B
|
Glioblastoma
|
|
0.730 |
GeneticVariation |
BEFREE |
We identified LIG4 rs7325927 and BTBD2 rs11670188 as predictors of STS in GBM and CCDC26 rs10464870 and rs891835, HMGA2 rs1563834, and RTEL1 rs2297440 as predictors of LTS.
|
20368557 |
2010 |
rs2297440
|
RTEL1;RTEL1-TNFRSF6B
|
Glioblastoma
|
|
0.730 |
GeneticVariation |
BEFREE |
The opposite is true of RTEL (20q13) region polymorphisms, which are significantly associated with glioblastoma (rs2297440, OR = 0.56, P = 4.6 × 10(-10)) but not oligodendroglial tumor.
|
21356187 |
2011 |
rs2297440
|
RTEL1;RTEL1-TNFRSF6B
|
Glioblastoma Multiforme
|
|
0.730 |
GeneticVariation |
BEFREE |
The opposite is true of RTEL (20q13) region polymorphisms, which are significantly associated with glioblastoma (rs2297440, OR = 0.56, P = 4.6 × 10(-10)) but not oligodendroglial tumor.
|
21356187 |
2011 |
rs2297440
|
RTEL1;RTEL1-TNFRSF6B
|
Glioblastoma
|
|
0.730 |
GeneticVariation |
BEFREE |
Using the χ(2) test, we found that rs2297440 and rs6010620 in RTEL1 increased risk of GBM.
|
26156397 |
2015 |
rs2297440
|
RTEL1;RTEL1-TNFRSF6B
|
Glioblastoma Multiforme
|
|
0.730 |
GeneticVariation |
BEFREE |
We identified LIG4 rs7325927 and BTBD2 rs11670188 as predictors of STS in GBM and CCDC26 rs10464870 and rs891835, HMGA2 rs1563834, and RTEL1 rs2297440 as predictors of LTS.
|
20368557 |
2010 |