|
rs151214675
|
RTEL1;RTEL1-TNFRSF6B
|
Age related macular degeneration
|
|
0.010 |
GeneticVariation |
BEFREE |
After correcting for multiple testing (n = 37,428), we identified four variants significantly associated with AMD: rs200437673 (LCN9, p = 1.50 × 10<sup>-11</sup>), rs151214675 (RTEL1, p = 3.18 × 10<sup>-8</sup>), rs140250387 (DLGAP1, p = 4.49 × 10<sup>-7</sup>), and rs115333865 (CGRRF1, p = 1.05 × 10<sup>-6</sup>).
|
31367973 |
2019 |
|
rs2297441
|
TNFRSF6B;RTEL1;RTEL1-TNFRSF6B
|
Prostate carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>RTEL1</i> rs2297441 [odds ratio (OR): 1.23; 95% confidence interval (CI): 1.03-1.46, <i>P</i> = 0.021] and rs3208008 (OR: 1.23; 95% CI: 1.03-1.46) were associated with PCa risk.
|
31762827 |
2019 |
|
rs2297441
|
TNFRSF6B;RTEL1;RTEL1-TNFRSF6B
|
Malignant neoplasm of prostate
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>RTEL1</i> rs2297441 [odds ratio (OR): 1.23; 95% confidence interval (CI): 1.03-1.46, <i>P</i> = 0.021] and rs3208008 (OR: 1.23; 95% CI: 1.03-1.46) were associated with PCa risk.
|
31762827 |
2019 |
|
rs3208008
|
TNFRSF6B;RTEL1;RTEL1-TNFRSF6B
|
Prostate carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>RTEL1</i> rs2297441 [odds ratio (OR): 1.23; 95% confidence interval (CI): 1.03-1.46, <i>P</i> = 0.021] and rs3208008 (OR: 1.23; 95% CI: 1.03-1.46) were associated with PCa risk.
|
31762827 |
2019 |
|
rs3208008
|
TNFRSF6B;RTEL1;RTEL1-TNFRSF6B
|
Malignant neoplasm of prostate
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>RTEL1</i> rs2297441 [odds ratio (OR): 1.23; 95% confidence interval (CI): 1.03-1.46, <i>P</i> = 0.021] and rs3208008 (OR: 1.23; 95% CI: 1.03-1.46) were associated with PCa risk.
|
31762827 |
2019 |
|
rs4809324
|
RTEL1;RTEL1-TNFRSF6B
|
Coronary heart disease
|
|
0.010 |
GeneticVariation |
BEFREE |
In the allele model, using the chi-square test, we found that the patients with the "G" allele of rs6010620 and the "C" allele of rs4809324 in the RTEL1 gene showed a decreased risk of CHD once the results were adjusted for age and gender.
|
30623606 |
2019 |
|
rs6010620
|
RTEL1;RTEL1-TNFRSF6B
|
Coronary heart disease
|
|
0.010 |
GeneticVariation |
BEFREE |
In the genetic model, logistic regression analyses revealed that the rs6010620 polymorphism conferred a decreased risk of CHD in the codominant model (OR = 0.52, 95% CI: 0.31-0.88, p = 0.007 for the "G/G" genotype) and the recessive model (OR = 0.49, 95% CI: 0.30-0.80, p = 0.004 for the "G/G" genotype).
|
30623606 |
2019 |
|
rs115303435
|
TNFRSF6B;RTEL1;RTEL1-TNFRSF6B
|
Glioma
|
|
0.010 |
GeneticVariation |
BEFREE |
The glioma subgroup analyses showed that the causal variants (rs6062302 and rs115303435) may be associated with increased risk of glioma</span> regardless of histological grades and molecular alterations.
|
30462709 |
2018 |
|
rs6062302
|
RTEL1;RTEL1-TNFRSF6B
|
Glioma
|
|
0.010 |
GeneticVariation |
BEFREE |
The glioma subgroup analyses showed that the causal variants (rs6062302 and rs115303435) may be associated with increased risk of glioma regardless of histological grades and molecular alterations.
|
30462709 |
2018 |
|
rs2297441
|
TNFRSF6B;RTEL1;RTEL1-TNFRSF6B
|
High altitude pulmonary edema
|
|
0.010 |
GeneticVariation |
BEFREE |
In the genetic model analysis, we found that rs6010621, rs6089953, and rs2297441 were relevant to decreased HAPE r</span>isk under dominant model (rs6010621: OR = 0.55; 95% CI = 0.39-0.78; P = .001; rs6089953: OR = 0.68; 95% CI = 0.48-0.96; P = .027; rs2297441: OR = 0.63; 95% CI = 0.45-0.89; P = .008, respectively) and additive model (rs6010621: OR = 0.51; 95% CI = 0.46-0.81; P < .001; rs6089953: OR = 0.72; 95% CI = 0.55-0.95; P = .022; rs2297441: OR = 0.73; 95% CI = 0.57-0.95; P = .019, respectively).
|
28953687 |
2017 |
|
rs4809324
|
RTEL1;RTEL1-TNFRSF6B
|
Chronic Obstructive Airway Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
In the genotype model analysis, we determined that rs4809324 polymorphism had a decreased effect on the risk of COPD (CC versus TT: OR =0.28; 95% CI =0.10-0.82; <i>P</i>=0.02).
|
28360516 |
2017 |
|
rs6010621
|
RTEL1;RTEL1-TNFRSF6B
|
High altitude pulmonary edema
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, haplotype "GG, GT, AT" of rs6089953-rs6010621 were detected significantly associated with HAPE risk (P < .05), haplotype "GG" remained significant after Bonferroni correction (P < .0025).
|
28953687 |
2017 |
|
rs6089953
|
RTEL1;RTEL1-TNFRSF6B
|
High altitude pulmonary edema
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, haplotype "GG, GT, AT" of rs6089953-rs6010621 were d</span>etected significantly associated with HAPE risk (P < .05), haplotype "GG" remained significant after Bonferroni correction (P < .0025).
|
28953687 |
2017 |
|
rs2738780
|
RTEL1;RTEL1-TNFRSF6B
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
Whereas rs2738780 showed a protective effect against LC (Odds ratio (OR) = 0.80 ;95% confidence interval (CI): 0.638 = 0.998; p = 0.048), rs7261546(OR = 4.16; 95% CI: 1.35-12.82; p = 0.007), rs6062299(OR=5.08; 95% CI: 1.43-18.10; p = 0.005) and rs3787098(OR = 5.10; 95% CI: 1.43-18.15; p = 0.004) were all associated with increased LC susceptibility (recessive model).
|
27765928 |
2016 |
|
rs2738780
|
RTEL1;RTEL1-TNFRSF6B
|
Primary malignant neoplasm of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
Whereas rs2738780 showed a protective effect against LC (Odds ratio (OR) = 0.80 ;95% confidence interval (CI): 0.638 = 0.998; p = 0.048), rs7261546(OR = 4.16; 95% CI: 1.35-12.82; p = 0.007), rs6062299(OR=5.08; 95% CI: 1.43-18.10; p = 0.005) and rs3787098(OR = 5.10; 95% CI: 1.43-18.15; p = 0.004) were all associated with increased LC susceptibility (recessive model).
|
27765928 |
2016 |
|
rs2738780
|
RTEL1;RTEL1-TNFRSF6B
|
Malignant neoplasm of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
Whereas rs2738780 showed a protective effect against LC (Odds ratio (OR) = 0.80 ;95% confidence interval (CI): 0.638 = 0.998; p = 0.048), rs7261546(OR = 4.16; 95% CI: 1.35-12.82; p = 0.007), rs6062299(OR=5.08; 95% CI: 1.43-18.10; p = 0.005) and rs3787098(OR = 5.10; 95% CI: 1.43-18.15; p = 0.004) were all associated with increased LC susceptibility (recessive model).
|
27765928 |
2016 |
|
rs34978822
|
RTEL1;RTEL1-TNFRSF6B
|
Malignant neoplasm of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
Near POT1, rs116895242 was inversely associated with colorectal, ovarian, and lung cancers, and RTEL1 rs34978822 was inversely associated with prostate and lung cancers.
|
27459707 |
2016 |
|
rs3787098
|
RTEL1;RTEL1-TNFRSF6B
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
Whereas rs2738780 showed a protective effect against LC (Odds ratio (OR) = 0.80 ;95% confidence interval (CI): 0.638 = 0.998; p = 0.048), rs7261546(OR = 4.16; 95% CI: 1.35-12.82; p = 0.007), rs6062299(OR=5.08; 95% CI: 1.43-18.10; p = 0.005) and rs3787098(OR = 5.10; 95% CI: 1.43-18.15; p = 0.004) were all associated with increased LC susceptibility (recessive model).
|
27765928 |
2016 |
|
rs3787098
|
RTEL1;RTEL1-TNFRSF6B
|
Primary malignant neoplasm of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
Whereas rs2738780 showed a protective effect against LC (Odds ratio (OR) = 0.80 ;95% confidence interval (CI): 0.638 = 0.998; p = 0.048), rs7261546(OR = 4.16; 95% CI: 1.35-12.82; p = 0.007), rs6062299(OR=5.08; 95% CI: 1.43-18.10; p = 0.005) and rs3787098(OR = 5.10; 95% CI: 1.43-18.15; p = 0.004) were all associated with increased LC susceptibility (recessive model).
|
27765928 |
2016 |
|
rs3787098
|
RTEL1;RTEL1-TNFRSF6B
|
Malignant neoplasm of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
Whereas rs2738780 showed a protective effect against LC (Odds ratio (OR) = 0.80 ;95% confidence interval (CI): 0.638 = 0.998; p = 0.048), rs7261546(OR = 4.16; 95% CI: 1.35-12.82; p = 0.007), rs6062299(OR=5.08; 95% CI: 1.43-18.10; p = 0.005) and rs3787098(OR = 5.10; 95% CI: 1.43-18.15; p = 0.004) were all associated with increased LC susceptibility (recessive model).
|
27765928 |
2016 |
|
rs6062299
|
RTEL1;RTEL1-TNFRSF6B
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
Whereas rs2738780 showed a protective effect against LC (Odds ratio (OR) = 0.80 ;95% confidence interval (CI): 0.638 = 0.998; p = 0.048), rs7261546(OR = 4.16; 95% CI: 1.35-12.82; p = 0.007), rs6062299(OR=5.08; 95% CI: 1.43-18.10; p = 0.005) and rs3787098(OR = 5.10; 95% CI: 1.43-18.15; p = 0.004) were all associated with increased LC susceptibility (recessive model).
|
27765928 |
2016 |
|
rs6062299
|
RTEL1;RTEL1-TNFRSF6B
|
Primary malignant neoplasm of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
Whereas rs2738780 showed a protective effect against LC (Odds ratio (OR) = 0.80 ;95% confidence interval (CI): 0.638 = 0.998; p = 0.048), rs7261546(OR = 4.16; 95% CI: 1.35-12.82; p = 0.007), rs6062299(OR=5.08; 95% CI: 1.43-18.10; p = 0.005) and rs3787098(OR = 5.10; 95% CI: 1.43-18.15; p = 0.004) were all associated with increased LC susceptibility (recessive model).
|
27765928 |
2016 |
|
rs6062299
|
RTEL1;RTEL1-TNFRSF6B
|
Malignant neoplasm of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
Whereas rs2738780 showed a protective effect against LC (Odds ratio (OR) = 0.80 ;95% confidence interval (CI): 0.638 = 0.998; p = 0.048), rs7261546(OR = 4.16; 95% CI: 1.35-12.82; p = 0.007), rs6062299(OR=5.08; 95% CI: 1.43-18.10; p = 0.005) and rs3787098(OR = 5.10; 95% CI: 1.43-18.15; p = 0.004) were all associated with increased LC susceptibility (recessive model).
|
27765928 |
2016 |
|
rs7261546
|
RTEL1;RTEL1-TNFRSF6B
|
Primary malignant neoplasm of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
Whereas rs2738780 showed a protective effect against LC (Odds ratio (OR) = 0.80 ;95% confidence interval (CI): 0.638 = 0.998; p = 0.048), rs7261546(OR = 4.16; 95% CI: 1.35-12.82; p = 0.007), rs6062299(OR=5.08; 95% CI: 1.43-18.10; p = 0.005) and rs3787098(OR = 5.10; 95% CI: 1.43-18.15; p = 0.004) were all associated with increased LC susceptibility (recessive model).
|
27765928 |
2016 |
|
rs7261546
|
RTEL1;RTEL1-TNFRSF6B
|
Carcinoma of lung
|
|
0.010 |
GeneticVariation |
BEFREE |
Whereas rs2738780 showed a protective effect against LC (Odds ratio (OR) = 0.80 ;95% confidence interval (CI): 0.638 = 0.998; p = 0.048), rs7261546(OR = 4.16; 95% CI: 1.35-12.82; p = 0.007), rs6062299(OR=5.08; 95% CI: 1.43-18.10; p = 0.005) and rs3787098(OR = 5.10; 95% CI: 1.43-18.15; p = 0.004) were all associated with increased LC susceptibility (recessive model).
|
27765928 |
2016 |