|
rs1458766475
|
SELE;C1orf112
|
Coronary heart disease
|
|
0.090 |
GeneticVariation |
BEFREE |
We found a correlation between the M235T molecular variant of AGT and the S128R variant of E-selectin to early severe CHD.
|
9020385 |
1997 |
|
rs5361
|
SELE;C1orf112
|
Coronary heart disease
|
|
0.090 |
GeneticVariation |
BEFREE |
We found a correlation between the M235T molecular variant of AGT and the S128R variant of E-selectin to early severe CHD.
|
9020385 |
1997 |
|
rs1458766475
|
SELE;C1orf112
|
Coronary heart disease
|
|
0.090 |
GeneticVariation |
BEFREE |
All P-selectin polymorphisms as well as a common E-selectin polymorphism, Ser128Arg which has been reported as being associated with an increased risk of premature coronary heart disease (CHD), and is in tight linkage disequilibrium with several P-selectin polymorphisms, were investigated in 647 patients with MI and 758 control subjects from four regions of France and Northern Ireland (the ECTIM study).
|
9668170 |
1998 |
|
rs5361
|
SELE;C1orf112
|
Coronary heart disease
|
|
0.090 |
GeneticVariation |
BEFREE |
All P-selectin polymorphisms as well as a common E-selectin polymorphism, Ser128Arg which has been reported as being associated with an increased risk of premature coronary heart disease (CHD), and is in tight linkage disequilibrium with several P-selectin polymorphisms, were investigated in 647 patients with MI and 758 control subjects from four regions of France and Northern Ireland (the ECTIM study).
|
9668170 |
1998 |
|
rs1458766475
|
SELE;C1orf112
|
Myocardial Infarction
|
|
0.040 |
GeneticVariation |
BEFREE |
All P-selectin polymorphisms as well as a common E-selectin polymorphism, Ser128Arg which has been reported as being associated with an increased risk of premature coronary heart disease (CHD), and is in tight linkage disequilibrium with several P-selectin polymorphisms, were investigated in 647 patients with MI and 758 control subjects from four regions of France and Northern Ireland (the ECTIM study).
|
9668170 |
1998 |
|
rs5361
|
SELE;C1orf112
|
Myocardial Infarction
|
|
0.040 |
GeneticVariation |
BEFREE |
All P-selectin polymorphisms as well as a common E-selectin polymorphism, Ser128Arg which has been reported as being associated with an increased risk of premature coronary heart disease (CHD), and is in tight linkage disequilibrium with several P-selectin polymorphisms, were investigated in 647 patients with MI and 758 control subjects from four regions of France and Northern Ireland (the ECTIM study).
|
9668170 |
1998 |
|
rs5361
|
SELE;C1orf112
|
Atherosclerosis
|
|
0.070 |
GeneticVariation |
BEFREE |
Functional characterization of atherosclerosis-associated Ser128Arg and Leu554Phe E-selectin mutations.
|
10430030 |
1999 |
|
rs5361
|
SELE;C1orf112
|
Arteriosclerosis
|
|
0.070 |
GeneticVariation |
BEFREE |
Functional characterization of atherosclerosis-associated Ser128Arg and Leu554Phe E-selectin mutations.
|
10430030 |
1999 |
|
rs1458766475
|
SELE;C1orf112
|
Arteriosclerosis
|
|
0.060 |
GeneticVariation |
BEFREE |
Functional characterization of atherosclerosis-associated Ser128Arg and Leu554Phe E-selectin mutations.
|
10430030 |
1999 |
|
rs1458766475
|
SELE;C1orf112
|
Atherosclerosis
|
|
0.060 |
GeneticVariation |
BEFREE |
Functional characterization of atherosclerosis-associated Ser128Arg and Leu554Phe E-selectin mutations.
|
10430030 |
1999 |
|
rs5355
|
SELE;C1orf112
|
Arteriosclerosis
|
|
0.020 |
GeneticVariation |
BEFREE |
Functional characterization of atherosclerosis-associated Ser128Arg and Leu554Phe E-selectin mutations.
|
10430030 |
1999 |
|
rs5355
|
SELE;C1orf112
|
Atherosclerosis
|
|
0.020 |
GeneticVariation |
BEFREE |
Functional characterization of atherosclerosis-associated Ser128Arg and Leu554Phe E-selectin mutations.
|
10430030 |
1999 |
|
rs1131498
|
SELL;C1orf112
|
Diabetes Mellitus
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of our study was to evaluate the frequency of the L-selectin gene T668C mutation (from thymine to cytosine at position 668) resulted in F206L an amino acid substitution in patients with overt diabetes and their unaffected first degree relatives in comparison to the unselected control population.
|
11064106 |
2000 |
|
rs1131498
|
SELL;C1orf112
|
Diabetes
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of our study was to evaluate the frequency of the L-selectin gene T668C mutation (from thymine to cytosine at position 668) resulted in F206L an amino acid substitution in patients with overt diabetes and their unaffected first degree relatives in comparison to the unselected control population.
|
11064106 |
2000 |
|
rs1131498
|
SELL;C1orf112
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.010 |
GeneticVariation |
BEFREE |
It was also shown that there is an association between T668C mutation and low HLA related risk of IDDM development, the highest frequency of F206L mutation in the EGF domain of L-selectin was observed in relatives with 'protective' HLA DQB1*0602 allele and nonDRB1*03-nonDRB1*04 haplotype, while in subjects with highest risk of IDDM haplotype the frequency of T668C mutation was similar to the controls.
|
11064106 |
2000 |
|
rs5361
|
SELE;C1orf112
|
Coronary Artery Disease
|
|
0.080 |
GeneticVariation |
BEFREE |
After controlling for other CAD risk factors (plasma total cholesterol, triglyceride, LDL-apolipoprotein B. cigarette smoking and the S128R mutation) by multiple logistic analysis, the G98T mutation in the E-selectin gene was still a significant predictor of premature CAD [p = 0.022, odds ratio (95%, CI)= 3.58 (1.20-10.67)].
|
11168027 |
2001 |
|
rs1458766475
|
SELE;C1orf112
|
Coronary Artery Disease
|
|
0.070 |
GeneticVariation |
BEFREE |
After controlling for other CAD risk factors (plasma total cholesterol, triglyceride, LDL-apolipoprotein B. cigarette smoking and the S128R mutation) by multiple logistic analysis, the G98T mutation in the E-selectin gene was still a significant predictor of premature CAD [p = 0.022, odds ratio (95%, CI)= 3.58 (1.20-10.67)].
|
11168027 |
2001 |
|
rs5361
|
SELE;C1orf112
|
Arteriosclerosis
|
|
0.070 |
GeneticVariation |
BEFREE |
Relationships between the E-selectin S128R polymorphism and coronary artery calcification (CAC), a marker of atherosclerosis detected with noninvasive electron beam computed tomography, were examined in 294 asymptomatic women aged 40--88 years and 314 asymptomatic men aged 30--80 years from the Epidemiology of Coronary Artery Calcification Study.
|
11466561 |
2001 |
|
rs5361
|
SELE;C1orf112
|
Atherosclerosis
|
|
0.070 |
GeneticVariation |
BEFREE |
Relationships between the E-selectin S128R polymorphism and coronary artery calcification (CAC), a marker of atherosclerosis detected with noninvasive electron beam computed tomography, were examined in 294 asymptomatic women aged 40--88 years and 314 asymptomatic men aged 30--80 years from the Epidemiology of Coronary Artery Calcification Study.
|
11466561 |
2001 |
|
rs1458766475
|
SELE;C1orf112
|
Atherosclerosis
|
|
0.060 |
GeneticVariation |
BEFREE |
Relationships between the E-selectin S128R polymorphism and coronary artery calcification (CAC), a marker of atherosclerosis detected with noninvasive electron beam computed tomography, were examined in 294 asymptomatic women aged 40--88 years and 314 asymptomatic men aged 30--80 years from the Epidemiology of Coronary Artery Calcification Study.
|
11466561 |
2001 |
|
rs1458766475
|
SELE;C1orf112
|
Arteriosclerosis
|
|
0.060 |
GeneticVariation |
BEFREE |
Relationships between the E-selectin S128R polymorphism and coronary artery calcification (CAC), a marker of atherosclerosis detected with noninvasive electron beam computed tomography, were examined in 294 asymptomatic women aged 40--88 years and 314 asymptomatic men aged 30--80 years from the Epidemiology of Coronary Artery Calcification Study.
|
11466561 |
2001 |
|
rs5361
|
SELE;C1orf112
|
Coronary Artery Disease
|
|
0.080 |
GeneticVariation |
BEFREE |
The Ser128Arg polymorphism of E-selectin was analyzed in 101 (derivation) and 92 (validation) CAD patients.
|
12036529 |
2002 |
|
rs1458766475
|
SELE;C1orf112
|
Coronary Artery Disease
|
|
0.070 |
GeneticVariation |
BEFREE |
The Ser128Arg polymorphism of E-selectin was analyzed in 101 (derivation) and 92 (validation) CAD patients.
|
12036529 |
2002 |
|
rs1458766475
|
SELE;C1orf112
|
Coronary heart disease
|
|
0.090 |
GeneticVariation |
BEFREE |
In subjects suffering from diabetes mellitus type 2 the E-selectin S128R polymorphism is not associated with coronary artery disease nor with an increased risk for myocardial infarction.
|
15013273 |
2003 |
|
rs5361
|
SELE;C1orf112
|
Coronary heart disease
|
|
0.090 |
GeneticVariation |
BEFREE |
In subjects suffering from diabetes mellitus type 2 the E-selectin S128R polymorphism is not associated with coronary artery disease nor with an increased risk for myocardial infarction.
|
15013273 |
2003 |