PTGS1, prostaglandin-endoperoxide synthase 1, 5742

N. diseases: 318; N. variants: 36
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1160235906
rs1160235906
Entrez Id: 5742
Gene Symbol: PTGS1
PTGS1
CUI: C0578870
Disease:
Chronic idiopathic urticaria 		0.010 GeneticVariation BEFREE A multiple regression model was found to show that COX-2 5'UTR T/G, COX-2 Exon 10 T/C, and FLAP -336 G/A polymorphisms were significantly associated with CSU, with the minor allele more represented in CSU group. 21227888 2011
dbSNP: rs200028534
rs200028534
Entrez Id: 5742
Gene Symbol: PTGS1
PTGS1
CUI: C0578870
Disease:
Chronic idiopathic urticaria 		0.010 GeneticVariation BEFREE A multiple regression model was found to show that COX-2 5'UTR T/G, COX-2 Exon 10 T/C, and FLAP -336 G/A polymorphisms were significantly associated with CSU, with the minor allele more represented in CSU group. 21227888 2011
dbSNP: rs1330344
rs1330344
Entrez Id: 5742
Gene Symbol: PTGS1
PTGS1
CUI: C0948008
Disease:
Ischemic stroke 		0.020 GeneticVariation BEFREE At rs1330344</span>, AA genotype may reduce the susceptibility of ischemic stroke. 31735164 2019
dbSNP: rs3842788
rs3842788
Entrez Id: 5742
Gene Symbol: PTGS1
PTGS1
CUI: C0948008
Disease:
Ischemic stroke 		0.020 GeneticVariation BEFREE At rs3842788, AA genotype may increase the susceptibility of ischemic stroke. 31735164 2019
dbSNP: rs1440603985
rs1440603985
Entrez Id: 5742
Gene Symbol: PTGS1
PTGS1
CUI: C0009402
Disease:
Colorectal Carcinoma 		0.010 GeneticVariation BEFREE Carriage of the minor allele of UBD I68T was significantly associated with advanced stages of CRC and with CRC below 65 years of age (OR, 1.23; 95% CI, 1.04-1.45; p = 0.02 and OR, 1.32; 95% CI, 1.05-1.67; p = 0.02, respectively). 21351261 2010
dbSNP: rs3842787
rs3842787
Entrez Id: 5742
Gene Symbol: PTGS1
PTGS1
CUI: C1306459
Disease:
Primary malignant neoplasm 		0.010 GeneticVariation BEFREE For PTGS1 rs3842787, NSAID users homozygous for the major allele (CC) had a significantly decreased cancer risk compared with non-NSAID users (OR = 0.73, 95% CI = 0.59-0.89). 23967159 2013
dbSNP: rs3842787
rs3842787
Entrez Id: 5742
Gene Symbol: PTGS1
PTGS1
CUI: C0006826
Disease:
Malignant Neoplasms 		0.010 GeneticVariation BEFREE For PTGS1 rs3842787, NSAID users homozygous for the major allele (CC) had a significantly decreased cancer risk compared with non-NSAID users (OR = 0.73, 95% CI = 0.59-0.89). 23967159 2013
dbSNP: rs10306135
rs10306135
Entrez Id: 5742
Gene Symbol: PTGS1
PTGS1
CUI: C0007222
Disease:
Cardiovascular Diseases 		0.010 GeneticVariation BEFREE Furthermore, individuals homozygote for the variant allele rs10306135 had lower prevalence of CVD, compared to the common allele (0% versus 30%, P=0.0047). 19091535 2009
dbSNP: rs10306141
rs10306141
Entrez Id: 5742
Gene Symbol: PTGS1
PTGS1
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		C 0.700 GeneticVariation GWASCAT Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. 27903959 2017
dbSNP: rs10306152
rs10306152
Entrez Id: 5742
Gene Symbol: PTGS1
PTGS1
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		C 0.700 GeneticVariation GWASCAT Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. 27903959 2017
dbSNP: rs10306156
rs10306156
Entrez Id: 5742
Gene Symbol: PTGS1
PTGS1
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		T 0.700 GeneticVariation GWASCAT Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. 27903959 2017
dbSNP: rs10306157
rs10306157
Entrez Id: 5742
Gene Symbol: PTGS1
PTGS1
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		G 0.700 GeneticVariation GWASCAT Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. 27903959 2017
dbSNP: rs10306166
rs10306166
Entrez Id: 5742
Gene Symbol: PTGS1
PTGS1
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		G 0.700 GeneticVariation GWASCAT Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. 27903959 2017
dbSNP: rs10306182
rs10306182
Entrez Id: 5742
Gene Symbol: PTGS1
PTGS1
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		T 0.700 GeneticVariation GWASCAT Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. 27903959 2017
dbSNP: rs10306183
rs10306183
Entrez Id: 5742
Gene Symbol: PTGS1
PTGS1
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		C 0.700 GeneticVariation GWASCAT Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. 27903959 2017
dbSNP: rs10306184
rs10306184
Entrez Id: 5742
Gene Symbol: PTGS1
PTGS1
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		T 0.700 GeneticVariation GWASCAT Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. 27903959 2017
dbSNP: rs10306194
rs10306194
Entrez Id: 5742
Gene Symbol: PTGS1
PTGS1
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		C 0.700 GeneticVariation GWASCAT Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. 27903959 2017
dbSNP: rs3842802
rs3842802
Entrez Id: 5742
Gene Symbol: PTGS1
PTGS1
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		G 0.700 GeneticVariation GWASCAT Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. 27903959 2017
dbSNP: rs3842803
rs3842803
Entrez Id: 5742
Gene Symbol: PTGS1
PTGS1
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		T 0.700 GeneticVariation GWASCAT Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. 27903959 2017
dbSNP: rs4240474
rs4240474
Entrez Id: 5742
Gene Symbol: PTGS1
PTGS1
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		A 0.700 GeneticVariation GWASCAT Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. 27903959 2017
dbSNP: rs4240474
rs4240474
Entrez Id: 5742
Gene Symbol: PTGS1
PTGS1
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		G 0.700 GeneticVariation GWASCAT Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. 27903959 2017
dbSNP: rs4273915
rs4273915
Entrez Id: 5742
Gene Symbol: PTGS1
PTGS1
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		C 0.700 GeneticVariation GWASCAT Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. 27903959 2017
dbSNP: rs4836886
rs4836886
Entrez Id: 5742
Gene Symbol: PTGS1
PTGS1
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		T 0.700 GeneticVariation GWASCAT Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. 27903959 2017
dbSNP: rs4836888
rs4836888
Entrez Id: 5742
Gene Symbol: PTGS1
PTGS1
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		G 0.700 GeneticVariation GWASCAT Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. 27903959 2017
dbSNP: rs9299280
rs9299280
Entrez Id: 5742
Gene Symbol: PTGS1
PTGS1
CUI: C0023467
Disease:
Leukemia, Myelocytic, Acute 		A 0.700 GeneticVariation GWASCAT Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. 27903959 2017