Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs12493901
rs12493901
Entrez Id: 64778
Gene Symbol: FNDC3B
FNDC3B
CUI: C4049938
Disease:
Physical Activity Measurement 		G 0.700 GeneticVariation GWASCAT Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults. 28448500 2017
dbSNP: rs12493901
rs12493901
Entrez Id: 64778
Gene Symbol: FNDC3B
FNDC3B
CUI: C1519383
Disease:
Smoking Behaviors 		A 0.700 GeneticVariation GWASCAT Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. 28443625 2017
dbSNP: rs35461662
rs35461662
Entrez Id: 64778
Gene Symbol: FNDC3B
FNDC3B
CUI: C0427460
Disease:
Red cell distribution width determination 		A 0.700 GeneticVariation GWASCAT Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers. 28957414 2017
dbSNP: rs35461662
rs35461662
Entrez Id: 64778
Gene Symbol: FNDC3B
FNDC3B
CUI: C1304746
Disease:
RDW - Red blood cell distribution width result 		A 0.700 GeneticVariation GWASCAT Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers. 28957414 2017
dbSNP: rs62281815
rs62281815
Entrez Id: 64778
Gene Symbol: FNDC3B
FNDC3B
CUI: C0005890
Disease:
Body Height 		A 0.700 GeneticVariation GWASCAT Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits. 28552196 2017
dbSNP: rs6445055
rs6445055
Entrez Id: 64778
Gene Symbol: FNDC3B
FNDC3B
CUI: C0040420
Disease:
Tonometry 		0.700 GeneticVariation GWASCAT A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure. 29235454 2017
dbSNP: rs7635832
rs7635832
Entrez Id: 64778
Gene Symbol: FNDC3B
FNDC3B
CUI: C0040420
Disease:
Tonometry 		G 0.700 GeneticVariation GWASCAT New insights into the genetics of primary open-angle glaucoma based on meta-analyses of intraocular pressure and optic disc characteristics. 28073927 2017
dbSNP: rs7635832
rs7635832
Entrez Id: 64778
Gene Symbol: FNDC3B
FNDC3B
CUI: C0040420
Disease:
Tonometry 		0.700 GeneticVariation GWASCAT A large multi-ethnic genome-wide association study identifies novel genetic loci for intraocular pressure. 29235454 2017
dbSNP: rs397778518
rs397778518
Entrez Id: 64778
Gene Symbol: FNDC3B
FNDC3B
CUI: C0206161
Disease:
Reticulocyte count (procedure) 		CT 0.700 GeneticVariation GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
dbSNP: rs6763687
rs6763687
Entrez Id: 64778
Gene Symbol: FNDC3B
FNDC3B
CUI: C1304746
Disease:
RDW - Red blood cell distribution width result 		T 0.700 GeneticVariation GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
dbSNP: rs6763687
rs6763687
Entrez Id: 64778
Gene Symbol: FNDC3B
FNDC3B
CUI: C0427460
Disease:
Red cell distribution width determination 		T 0.700 GeneticVariation GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
dbSNP: rs4243400
rs4243400
Entrez Id: 64778
Gene Symbol: FNDC3B
FNDC3B
CUI: C0005890
Disease:
Body Height 		A 0.700 GeneticVariation GWASCAT Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. 25429064 2015
dbSNP: rs6445055
rs6445055
Entrez Id: 64778
Gene Symbol: FNDC3B
FNDC3B
CUI: C0040420
Disease:
Tonometry 		A 0.700 GeneticVariation GWASCAT Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma. 25173106 2014
dbSNP: rs7652177
rs7652177
Entrez Id: 64778
Gene Symbol: FNDC3B
FNDC3B
CUI: C0005890
Disease:
Body Height 		C 0.700 GeneticVariation GWASCAT Defining the role of common variation in the genomic and biological architecture of adult human height. 25282103 2014
dbSNP: rs4535251
rs4535251
Entrez Id: 64778
Gene Symbol: FNDC3B
FNDC3B
CUI: C0005890
Disease:
Body Height 		T 0.700 GeneticVariation GWASCAT Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. 23563607 2013
dbSNP: rs4535251
rs4535251
Entrez Id: 64778
Gene Symbol: FNDC3B
FNDC3B
CUI: C0489786
Disease:
Height 		T 0.700 GeneticVariation GWASDB Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. 23563607 2013
dbSNP: rs6445055
rs6445055
Entrez Id: 64778
Gene Symbol: FNDC3B
FNDC3B
CUI: C0524957
Disease:
Corneal Topography 		0.700 GeneticVariation GWASDB Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus. 23291589 2013
dbSNP: rs7652177
rs7652177
Entrez Id: 64778
Gene Symbol: FNDC3B
FNDC3B
CUI: C0005890
Disease:
Body Height 		0.700 GeneticVariation GWASCAT Hundreds of variants clustered in genomic loci and biological pathways affect human height. 20881960 2010
dbSNP: rs7652177
rs7652177
Entrez Id: 64778
Gene Symbol: FNDC3B
FNDC3B
CUI: C0489786
Disease:
Height 		0.700 GeneticVariation GWASDB Hundreds of variants clustered in genomic loci and biological pathways affect human height. 20881960 2010
dbSNP: rs4894535
rs4894535
Entrez Id: 64778
Gene Symbol: FNDC3B
FNDC3B
CUI: C0022578
Disease:
Keratoconus 		0.030 GeneticVariation BEFREE SNPs rs4954218 (Near RAB3GAP1 (5')), rs4894535 (FNDC3B), rs2956540 (LOX), rs3735520 (Near HGF (5')), rs1324183 (MPDZ-NF1B), rs1536482 (RXRA-COL5A1), rs7044529 (COL5A1), rs2721051 (Near FOXO1 (3')), rs9938149 (BANP-ZNF469) and rs6050307 (VSX1) were assessed for their association with KC. 25675348 2015
dbSNP: rs4894535
rs4894535
Entrez Id: 64778
Gene Symbol: FNDC3B
FNDC3B
CUI: C0022578
Disease:
Keratoconus 		0.030 GeneticVariation BEFREE We further showed that 2 CCT-associated loci, FOXO1 and FNDC3B, conferred relatively large risks for keratoconus in 2 cohorts with 874 cases and 6,085 controls (rs2721051 near FOXO1 had odds ratio (OR) = 1.62, 95% confidence interval (CI) = 1.4-1.88, P = 2.7 × 10(-10), and rs4894535 in FNDC3B had OR = 1.47, 95% CI = 1.29-1.68, P = 4.9 × 10(-9)). 23291589 2013
dbSNP: rs4894535
rs4894535
Entrez Id: 64778
Gene Symbol: FNDC3B
FNDC3B
CUI: C0022578
Disease:
Keratoconus 		0.030 GeneticVariation BEFREE The following six single-nucleotide polymorphisms (SNPs) that showed a statistically significant association with KC in a recent GWAS study were selected for genotyping in our cohort: rs4894535 (FNDC3B), rs1324183 (MPDZ-NF1B), rs1536482 (RXRA-COL5A1), rs7044529 (COL5A), rs2721051 (FOXO1), and rs9938149 (BANP-ZNF469). 24265017 2013
dbSNP: rs111698934
rs111698934
Entrez Id: 64778
Gene Symbol: FNDC3B
FNDC3B
CUI: C0339573
Disease:
Glaucoma, Primary Open Angle 		0.010 GeneticVariation BEFREE An association with POAG in FNDC3B (rs111698934; P < 3.9×10<sup>-5</sup>) was observed, not in linkage disequilibrium (LD) with the previously reported ED SNP. 30352225 2019
dbSNP: rs6445055
rs6445055
Entrez Id: 64778
Gene Symbol: FNDC3B
FNDC3B
CUI: C0339573
Disease:
Glaucoma, Primary Open Angle 		0.010 GeneticVariation BEFREE We confirm genetic association of known loci for IOP and primary open-angle glaucoma (POAG) and identify four new IOP-associated loci located on chromosome 3q25.31 within the FNDC3B gene (P = 4.19 × 10(-8) for rs6445055), two on chromosome 9 (P = 2.80 × 10(-11) for rs2472493 near ABCA1 and P = 6.39 × 10(-11) for rs8176693 within ABO) and one on chromosome 11p11.2 (best P = 1.04 × 10(-11) for rs747782). 25173106 2014
dbSNP: rs6445055
rs6445055
Entrez Id: 64778
Gene Symbol: FNDC3B
FNDC3B
CUI: C0595921
Disease:
Intraocular pressure disorder 		0.010 GeneticVariation BEFREE We confirm genetic association of known loci for IOP and primary open-angle glaucoma (POAG) and identify four new IOP-associated loci located on chromosome 3q25.31 within the FNDC3B gene (P = 4.19 × 10(-8) for rs6445055), two on chromosome 9 (P = 2.80 × 10(-11) for rs2472493 near ABCA1 and P = 6.39 × 10(-11) for rs8176693 within ABO) and one on chromosome 11p11.2 (best P = 1.04 × 10(-11) for rs747782). 25173106 2014