Other genotypes, such as the TT in SHH rs104894049 331 A/T and the GG in SMO rs41303402385 G/A also statistically raised the risk of BCC, but these associations were weaker.
Other genotypes, such as the TT in SHH rs104894049 331 A/T and the GG in SMO rs41303402385 G/A also statistically raised the risk of BCC, but these associations were weaker.
These results mainly underline the potential role of SHH3 rs104894040 349 T/C gene polymorphism in the development of skin basal cell carcinomas in patients of Polish origin.
In multivariate logistic regression analysis, TNM stage (p = 0.001), recipient SMO rs3824 genotype (CG vs. CC/GG p = 0.001), and histologic grade (p = 0.019) were identified as independent risk factors of HCC recurrence.
A subset of meningiomas lacking NF2 alterations harbored recurrent oncogenic mutations in AKT1 (p.Glu17Lys) and SMO (p.Trp535Leu) and exhibited immunohistochemical evidence of activation of these pathways.