DisGeNET - a database of gene-disease associations

IL18RAP, interleukin 18 receptor accessory protein, 8807

N. diseases: 41; N. variants: 22

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Disease

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs2058660

Entrez Id:	8807
Gene Symbol:	IL18RAP

IL18RAP

CUI:	C0010346
Disease:

Crohn Disease

0.810

GeneticVariation

BEFREE

One of the strongest eQTL identified (rs2058660) is also the tagSNP of a linkage block reported to affect leprosy and Crohn's disease in opposite directions.

26259071

2015

dbSNP:

rs2058660

Entrez Id:	8807
Gene Symbol:	IL18RAP

IL18RAP

CUI:	C0010346
Disease:

Crohn Disease

0.810

GeneticVariation

GWASDB

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.

21102463

2010

dbSNP:

rs2058660

Entrez Id:	8807
Gene Symbol:	IL18RAP

IL18RAP

CUI:	C0010346
Disease:

Crohn Disease

0.810

GeneticVariation

GWASCAT

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.

21102463

2010

dbSNP:

rs1420106

Entrez Id:	8807
Gene Symbol:	IL18RAP

IL18RAP

CUI:	C2985280
Disease:

Blood Protein Measurement

0.700

GeneticVariation

GWASCAT

Genomic atlas of the human plasma proteome.

29875488

2018

dbSNP:

rs11681718

Entrez Id:	8807
Gene Symbol:	IL18RAP

IL18RAP

CUI:	C0024141
Disease:

Lupus Erythematosus, Systemic

0.700

GeneticVariation

GWASCAT

Transancestral mapping and genetic load in systemic lupus erythematosus.

28714469

2017

dbSNP:

rs12997015

Entrez Id:	8807
Gene Symbol:	IL18RAP

IL18RAP

CUI:	C4553157
Disease:

Interleukin 1 Receptor-Like 1 Measurement

0.700

GeneticVariation

GWASCAT

Connecting genetic risk to disease end points through the human blood plasma proteome.

28240269

2017

dbSNP:

rs34020101

Entrez Id:	8807
Gene Symbol:	IL18RAP

IL18RAP

CUI:	C0200641
Disease:

Blood basophil count (lab test)

0.700

GeneticVariation

GWASCAT

The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

27863252

2016

dbSNP:

rs34020101

Entrez Id:	8807
Gene Symbol:	IL18RAP

IL18RAP

CUI:	C0200638
Disease:

Eosinophil count procedure

0.700

GeneticVariation

GWASCAT

The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

27863252

2016

dbSNP:

rs6708413

Entrez Id:	8807
Gene Symbol:	IL18RAP

IL18RAP

CUI:	C0021390
Disease:

Inflammatory Bowel Diseases

0.700

GeneticVariation

GWASCAT

Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.

26192919

2015

dbSNP:

rs6708413

Entrez Id:	8807
Gene Symbol:	IL18RAP

IL18RAP

CUI:	C0010346
Disease:

Crohn Disease

0.700

GeneticVariation

GWASCAT

Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.

26192919

2015

dbSNP:

rs10166330

Entrez Id:	8807
Gene Symbol:	IL18RAP

IL18RAP

CUI:	C1527304
Disease:

Allergic Reaction

0.700

GeneticVariation

GWASDB

A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.

23817569

2013

dbSNP:

rs10176820

Entrez Id:	8807
Gene Symbol:	IL18RAP

IL18RAP

CUI:	C1527304
Disease:

Allergic Reaction

0.700

GeneticVariation

GWASDB

A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.

23817569

2013

dbSNP:

rs17027166

Entrez Id:	8807
Gene Symbol:	IL18RAP

IL18RAP

CUI:	C1527304
Disease:

Allergic Reaction

0.700

GeneticVariation

GWASDB

A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.

23817569

2013

dbSNP:

rs2075186

Entrez Id:	8807
Gene Symbol:	IL18RAP

IL18RAP

CUI:	C1527304
Disease:

Allergic Reaction

0.700

GeneticVariation

GWASDB

A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.

23817569

2013

dbSNP:

rs2272127

Entrez Id:	8807
Gene Symbol:	IL18RAP

IL18RAP

CUI:	C1527304
Disease:

Allergic Reaction

0.700

GeneticVariation

GWASDB

A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.

23817569

2013

dbSNP:

rs2293223

Entrez Id:	8807
Gene Symbol:	IL18RAP

IL18RAP

CUI:	C1527304
Disease:

Allergic Reaction

0.700

GeneticVariation

GWASDB

A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.

23817569

2013

dbSNP:

rs3771156

Entrez Id:	8807
Gene Symbol:	IL18RAP

IL18RAP

CUI:	C1527304
Disease:

Allergic Reaction

0.700

GeneticVariation

GWASDB

A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.

23817569

2013

dbSNP:

rs887971

Entrez Id:	8807
Gene Symbol:	IL18RAP

IL18RAP

CUI:	C1527304
Disease:

Allergic Reaction

0.700

GeneticVariation

GWASDB

A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.

23817569

2013

dbSNP:

rs887972

Entrez Id:	8807
Gene Symbol:	IL18RAP

IL18RAP

CUI:	C1527304
Disease:

Allergic Reaction

0.700

GeneticVariation

GWASDB

A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.

23817569

2013

dbSNP:

rs13401597

Entrez Id:	8807
Gene Symbol:	IL18RAP

IL18RAP

CUI:	C0202236
Disease:

Triglycerides measurement

0.700

GeneticVariation

GWASDB

Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

23063622

2012

dbSNP:

rs2310300

Entrez Id:	8807;100616157
Gene Symbol:	IL18RAP;MIR4772

IL18RAP;MIR4772

CUI:	C0004096
Disease:

Asthma

0.700

GeneticVariation

GWASDB

A large-scale, consortium-based genomewide association study of asthma.

20860503

2010

dbSNP:

rs3755266

Entrez Id:	8807
Gene Symbol:	IL18RAP

IL18RAP

CUI:	C0004096
Disease:

Asthma

0.700

GeneticVariation

GWASDB

A large-scale, consortium-based genomewide association study of asthma.

20860503

2010

dbSNP:

rs1420106

Entrez Id:	8807
Gene Symbol:	IL18RAP

IL18RAP

CUI:	C0391826
Disease:

Lhermitte-Duclos disease

0.010

GeneticVariation

BEFREE

Hence, this study was performed to understand the role of 2 IL18RAP (rs1420106 and rs917997) polymorphisms and IL18RAP plasma levels in lumbar disc degeneration (LDD) in Indian population.

31147177

2019

dbSNP:

rs1420106

Entrez Id:	8807
Gene Symbol:	IL18RAP

IL18RAP

CUI:	C0263874
Disease:

Degeneration of lumbar intervertebral disc

0.010

GeneticVariation

BEFREE

Hence, this study was performed to understand the role of 2 IL18RAP (rs1420106 and rs917997) polymorphisms and IL18RAP plasma levels in lumbar disc degeneration (LDD) in Indian population.

31147177

2019

dbSNP:

rs1420106

Entrez Id:	8807
Gene Symbol:	IL18RAP

IL18RAP

CUI:	C0221775
Disease:

Lumbar disc disease

0.010

GeneticVariation

BEFREE

Hence, this study was performed to understand the role of 2 IL18RAP (rs1420106 and rs917997) polymorphisms and IL18RAP plasma levels in lumbar disc degeneration (LDD) in Indian population.

31147177

2019