NRP1, neuropilin 1, 8829

N. diseases: 246; N. variants: 13
Disease: Tetralogy of Fallot ×
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2228638
rs2228638
Entrez Id: 8829
Gene Symbol: NRP1
NRP1
CUI: C0039685
Disease:
Tetralogy of Fallot 		0.820 GeneticVariation BEFREE The meta-analysis showed that the T allele of the NRP1 polymorphism rs2228638 was significantly associated with an increased risk of TOF in the combined population, which included European and Chinese Han individuals [combined p < 0.00001, odds ratio (OR) = 1.53, 95% confidence interval (95% CI) = 1.35-1.73]. 29432830 2018
dbSNP: rs2228638
rs2228638
Entrez Id: 8829
Gene Symbol: NRP1
NRP1
CUI: C0039685
Disease:
Tetralogy of Fallot 		0.820 GeneticVariation BEFREE We found that rs2228638 in NRP1 on 10p11 was significantly increased the risk of TOF (OR = 1.52, 95% CI = 1.13-2.04, P = 0.006), but not in other subgroups including ASD and VSD. 24594544 2014
dbSNP: rs2228638
rs2228638
Entrez Id: 8829
Gene Symbol: NRP1
NRP1
CUI: C0039685
Disease:
Tetralogy of Fallot 		A 0.820 GeneticVariation GWASDB Genome-wide association study identifies loci on 12q24 and 13q32 associated with tetralogy of Fallot. 23297363 2013
dbSNP: rs2228638
rs2228638
Entrez Id: 8829
Gene Symbol: NRP1
NRP1
CUI: C0039685
Disease:
Tetralogy of Fallot 		A 0.820 GeneticVariation GWASCAT Genome-wide association study identifies loci on 12q24 and 13q32 associated with tetralogy of Fallot. 23297363 2013
dbSNP: rs10080
rs10080
Entrez Id: 8829
Gene Symbol: NRP1
NRP1
CUI: C0039685
Disease:
Tetralogy of Fallot 		0.010 GeneticVariation BEFREE In addition, the association analysis suggested for the first time that there is a strong association between the allele distribution of rs10080 and susceptibility to TOF (p = 0.001). 29432830 2018