|
rs8042680
|
PRC1;PRC1-AS1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
A |
0.810 |
GeneticVariation |
GWASCAT |
Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.
|
28869590 |
2017 |
|
rs8042680
|
PRC1;PRC1-AS1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.810 |
GeneticVariation |
BEFREE |
Three T2D associated risk variants were individually associated with breast cancer risk after adjustment for multiple comparisons using the Bonferroni method (at p < 0.001), rs9939609 (FTO) (OR 0.94, 95 % CI = 0.92-0.95, p = 4.13E-13), rs7903146 (TCF7L2) (OR 1.04, 95 % CI = 1.02-1.06, p = 1.26E-05), and rs8042680 (PRC1) (OR 0.97, 95 % CI = 0.95-0.99, p = 8.05E-04).
|
27053251 |
2016 |
|
rs8042680
|
PRC1;PRC1-AS1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.810 |
GeneticVariation |
GWASDB |
Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.
|
23300278 |
2013 |
|
rs8042680
|
PRC1;PRC1-AS1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.810 |
GeneticVariation |
GWASDB |
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
|
22885922 |
2012 |
|
rs8042680
|
PRC1;PRC1-AS1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.810 |
GeneticVariation |
GWASDB |
Genome-wide association and meta-analysis in populations from Starr County, Texas, and Mexico City identify type 2 diabetes susceptibility loci and enrichment for expression quantitative trait loci in top signals.
|
21647700 |
2011 |
|
rs8042680
|
PRC1;PRC1-AS1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
A |
0.810 |
GeneticVariation |
GWASDB |
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
|
20581827 |
2010 |
|
rs8042680
|
PRC1;PRC1-AS1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
A |
0.810 |
GeneticVariation |
GWASCAT |
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
|
20581827 |
2010 |
|
rs2290203
|
PRC1;PRC1-AS1
|
Breast Carcinoma
|
G |
0.720 |
GeneticVariation |
GWASCAT |
Association analysis identifies 65 new breast cancer risk loci.
|
29059683 |
2017 |
|
rs2290203
|
PRC1;PRC1-AS1
|
Breast Carcinoma
|
|
0.720 |
GeneticVariation |
BEFREE |
We first validated that the SNPs rs12922061, rs2290203, and rs2981578 were associated with overall breast cancer risk in southeast Chinese women, with the per-allele OR of 1.209 (95%CI: 1.064-1.372), 1.176 (95%CI: 1.048-1.320), and 0.852 (95%CI: 0.759-0.956), respectively.
|
27705907 |
2016 |
|
rs2290203
|
PRC1;PRC1-AS1
|
Breast Carcinoma
|
|
0.720 |
GeneticVariation |
BEFREE |
In a three-stage genome-wide association study among East Asian women including 22,780 cases and 24,181 controls, we identified 3 genetic loci newly associated with breast cancer risk, including rs4951011 at 1q32.1 (in intron 2 of the ZC3H11A gene; P=8.82×10(-9)), rs10474352 at 5q14.3 (near the ARRDC3 gene; P=1.67×10(-9)) and rs2290203 at 15q26.1 (in intron 14 of the PRC1 gene; P=4.25×10(-8)).
|
25038754 |
2014 |
|
rs2290203
|
PRC1;PRC1-AS1
|
Breast Carcinoma
|
G |
0.720 |
GeneticVariation |
GWASCAT |
In a three-stage genome-wide association study among East Asian women including 22,780 cases and 24,181 controls, we identified 3 genetic loci newly associated with breast cancer risk, including rs4951011 at 1q32.1 (in intron 2 of the ZC3H11A gene; P=8.82×10(-9)), rs10474352 at 5q14.3 (near the ARRDC3 gene; P=1.67×10(-9)) and rs2290203 at 15q26.1 (in intron 14 of the PRC1 gene; P=4.25×10(-8)).
|
25038754 |
2014 |
|
rs2290203
|
PRC1;PRC1-AS1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population.
|
30718926 |
2019 |
|
rs12910825
|
PRC1;PRC1-AS1
|
Diabetes Mellitus, Non-Insulin-Dependent
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes.
|
30054458 |
2018 |
|
rs77554484
|
PRC1;PRC1-AS1
|
Breast Carcinoma
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Association analysis identifies 65 new breast cancer risk loci.
|
29059683 |
2017 |
|
rs12595025
|
PRC1;PRC1-AS1
|
Platelet mean volume determination (procedure)
|
T |
0.700 |
GeneticVariation |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
rs1867226
|
PRC1;PRC1-AS1
|
Blood Pressure
|
|
0.700 |
GeneticVariation |
GWASDB |
Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study.
|
21378095 |
2011 |
|
rs10520699
|
PRC1;PRC1-AS1
|
Breast Carcinoma
|
A |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs11852999
|
PRC1;PRC1-AS1
|
Breast Carcinoma
|
T |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs2290203
|
PRC1;PRC1-AS1
|
Malignant neoplasm of breast
|
|
0.020 |
GeneticVariation |
BEFREE |
We first validated that the SNPs rs12922061, rs2290203, and rs2981578 were associated with overall breast cancer risk in southeast Chinese women, with the per-allele OR of 1.209 (95%CI: 1.064-1.372), 1.176 (95%CI: 1.048-1.320), and 0.852 (95%CI: 0.759-0.956), respectively.
|
27705907 |
2016 |
|
rs2290203
|
PRC1;PRC1-AS1
|
Malignant neoplasm of breast
|
|
0.020 |
GeneticVariation |
BEFREE |
In a three-stage genome-wide association study among East Asian women including 22,780 cases and 24,181 controls, we identified 3 genetic loci newly associated with breast cancer risk, including rs4951011 at 1q32.1 (in intron 2 of the ZC3H11A gene; P=8.82×10(-9)), rs10474352 at 5q14.3 (near the ARRDC3 gene; P=1.67×10(-9)) and rs2290203 at 15q26.1 (in intron 14 of the PRC1 gene; P=4.25×10(-8)).
|
25038754 |
2014 |
|
rs8042680
|
PRC1;PRC1-AS1
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation |
BEFREE |
Three T2D associated risk variants were individually associated with breast cancer risk after adjustment for multiple comparisons using the Bonferroni method (at p < 0.001), rs9939609 (FTO) (OR 0.94, 95 % CI = 0.92-0.95, p = 4.13E-13), rs7903146 (TCF7L2) (OR 1.04, 95 % CI = 1.02-1.06, p = 1.26E-05), and rs8042680 (PRC1) (OR 0.97, 95 % CI = 0.95-0.99, p = 8.05E-04).
|
27053251 |
2016 |
|
rs8042680
|
PRC1;PRC1-AS1
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation |
BEFREE |
Three T2D associated risk variants were individually associated with breast cancer risk after adjustment for multiple comparisons using the Bonferroni method (at p < 0.001), rs9939609 (FTO) (OR 0.94, 95 % CI = 0.92-0.95, p = 4.13E-13), rs7903146 (TCF7L2) (OR 1.04, 95 % CI = 1.02-1.06, p = 1.26E-05), and rs8042680 (PRC1) (OR 0.97, 95 % CI = 0.95-0.99, p = 8.05E-04).
|
27053251 |
2016 |
|
rs1867226
|
PRC1;PRC1-AS1
|
Hypertensive disease
|
|
0.010 |
GeneticVariation |
BEFREE |
No variant reached genome wide significance for association with diastolic BP (top scoring SNP rs1867226, p = 5.8 x 10(-7)) or with hypertension as a binary trait (top scoring SNP rs9791170, p = 5.1 x 10(-7)).
|
19609347 |
2009 |