rs10192157
|
IL18R1;IL1RL1
|
Asthma
|
|
0.710 |
GeneticVariation |
GWASDB |
A large-scale, consortium-based genomewide association study of asthma.
|
20860503 |
2010 |
rs10204137
|
IL18R1;IL1RL1
|
Asthma
|
|
0.700 |
GeneticVariation |
GWASDB |
A large-scale, consortium-based genomewide association study of asthma.
|
20860503 |
2010 |
rs10206753
|
IL18R1;IL1RL1
|
Asthma
|
|
0.700 |
GeneticVariation |
GWASDB |
A large-scale, consortium-based genomewide association study of asthma.
|
20860503 |
2010 |
rs13431828
|
IL18R1;IL1RL1
|
Asthma
|
|
0.700 |
GeneticVariation |
GWASDB |
A large-scale, consortium-based genomewide association study of asthma.
|
20860503 |
2010 |
rs10197862
|
IL18R1;IL1RL1
|
Asthma
|
|
0.810 |
GeneticVariation |
BEFREE |
However, a variant in IL1RL1 that is in low linkage disequilibrium with that reported previously was associated with asthma risk after accounting for all variants tested (rs10197862, gene wide P = 0.01).
|
21150878 |
2011 |
rs1041973
|
IL18R1;IL1RL1
|
Asthma
|
|
0.010 |
GeneticVariation |
BEFREE |
In the total cohort, rs1041973 allele A was associated with a decreased risk of developing asthma (odds ratio, 0.70; 95% CI, 0.54-0.90).
|
21281963 |
2011 |
rs3771180
|
IL18R1;IL1RL1
|
Asthma
|
|
0.820 |
GeneticVariation |
GWASDB |
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
|
21804549 |
2011 |
rs3771180
|
IL18R1;IL1RL1
|
Asthma
|
|
0.820 |
GeneticVariation |
GWASCAT |
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
|
21804549 |
2011 |
rs10197862
|
IL18R1;IL1RL1
|
Asthma
|
|
0.810 |
GeneticVariation |
GWASDB |
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
|
21804549 |
2011 |
rs13408661
|
IL18R1;IL1RL1
|
Asthma
|
|
0.810 |
GeneticVariation |
GWASDB |
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
|
21804549 |
2011 |
rs10173081
|
IL18R1;IL1RL1
|
Asthma
|
|
0.700 |
GeneticVariation |
GWASDB |
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
|
21804549 |
2011 |
rs13408569
|
IL18R1;IL1RL1
|
Asthma
|
|
0.700 |
GeneticVariation |
GWASDB |
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
|
21804549 |
2011 |
rs13431828
|
IL18R1;IL1RL1
|
Asthma
|
|
0.700 |
GeneticVariation |
GWASDB |
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
|
21804549 |
2011 |
rs3771180
|
IL18R1;IL1RL1
|
Asthma
|
|
0.820 |
GeneticVariation |
BEFREE |
We also identified two genome-wide significant associations: rs13408661 near IL1RL1/IL18R1 (P(Stage1+Stage2) = 1.1x10(-9)), which is correlated with a variant recently shown to be associated with asthma (rs3771180), and rs9268516 in the HLA region (P(Stage1+Stage2) = 1.1x10(-8)), which appears to be independent of previously reported associations in this locus.
|
23028483 |
2012 |
rs13408661
|
IL18R1;IL1RL1
|
Asthma
|
G |
0.810 |
GeneticVariation |
GWASCAT |
We also identified two genome-wide significant associations: rs13408661 near IL1RL1/IL18R1 (P(Stage1+Stage2) = 1.1x10(-9)), which is correlated with a variant recently shown to be associated with asthma (rs3771180), and rs9268516 in the HLA region (P(Stage1+Stage2) = 1.1x10(-8)), which appears to be independent of previously reported associations in this locus.
|
23028483 |
2012 |
rs13408661
|
IL18R1;IL1RL1
|
Asthma
|
G |
0.810 |
GeneticVariation |
GWASDB |
We also identified two genome-wide significant associations: rs13408661 near IL1RL1/IL18R1 (P(Stage1+Stage2) = 1.1x10(-9)), which is correlated with a variant recently shown to be associated with asthma (rs3771180), and rs9268516 in the HLA region (P(Stage1+Stage2) = 1.1x10(-8)), which appears to be independent of previously reported associations in this locus.
|
23028483 |
2012 |
rs13408661
|
IL18R1;IL1RL1
|
Asthma
|
|
0.810 |
GeneticVariation |
BEFREE |
We also identified two genome-wide significant associations: rs13408661 near IL1RL1/IL18R1 (P(Stage1+Stage2) = 1.1x10(-9)), which is correlated with a variant recently shown to be associated with asthma (rs3771180), and rs9268516 in the HLA region (P(Stage1+Stage2) = 1.1x10(-8)), which appears to be independent of previously reported associations in this locus.
|
23028483 |
2012 |
rs201256810
|
IL18R1;IL1RL1
|
Asthma
|
|
0.010 |
GeneticVariation |
BEFREE |
GSDMB SNP rs2305480 (Ser311Pro) was associated with asthma diagnosis (p = 8.9×10-4), BHR (p = 8.2×10-4) and severity (p = 1.5×10-4) with supporting evidence from a second GSDMB SNP rs11078927 (intronic).
|
24066901 |
2013 |
rs10197862
|
IL18R1;IL1RL1
|
Asthma
|
A |
0.810 |
GeneticVariation |
GWASCAT |
Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.
|
24388013 |
2014 |
rs10208293
|
IL18R1;IL1RL1
|
Asthma
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Identification of a new locus at 16q12 associated with time to asthma onset.
|
27130862 |
2016 |
rs3771180
|
IL18R1;IL1RL1
|
Asthma
|
T |
0.820 |
GeneticVariation |
GWASCAT |
Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.
|
29273806 |
2018 |
rs1420101
|
IL18R1;IL1RL1
|
Asthma
|
T |
0.710 |
GeneticVariation |
GWASCAT |
Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.
|
29273806 |
2018 |
rs1420101
|
IL18R1;IL1RL1
|
Asthma
|
|
0.710 |
GeneticVariation |
BEFREE |
Finally, we determined the association of IL1RL1-a levels with asthma and its clinical characteristics (n=1101).<i>IL1RL1</i> asthma-risk SNPs strongly associated with <i>IL1RL1</i> methylation (rs1420101; p=3.7×10<sup>-16</sup>) and serum IL1RL1-a levels (p=2.8×10<sup>-56</sup>).
|
29519908 |
2018 |
rs72823641
|
IL18R1;IL1RL1
|
Asthma
|
|
0.700 |
GeneticVariation |
GWASCAT |
A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases.
|
29785011 |
2018 |
rs12479210
|
IL18R1;IL1RL1
|
Asthma
|
T |
0.700 |
GeneticVariation |
GWASCAT |
Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study.
|
30552067 |
2019 |