rs201256810
IL18R1;IL1RL1
Asthma
0.010
GeneticVariation
BEFREE
GSDMB SNP rs2305480 (Ser311Pro ) was associated with asthma diagnosis (p = 8.9×10-4), BHR (p = 8.2×10-4) and severity (p = 1.5×10-4) with supporting evidence from a second GSDMB SNP rs11078927 (intronic).
24066901
2013
rs1041973
IL18R1;IL1RL1
Asthma
0.010
GeneticVariation
BEFREE
In the total cohort, rs1041973 allele A was associated with a decreased risk of developing asthma (odds ratio, 0.70; 95% CI, 0.54-0.90).
21281963
2011
rs10208293
IL18R1;IL1RL1
Asthma
G
0.700
GeneticVariation
GWASCAT
Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.
31036433
2019
rs12470864
×
Entrez Id:
9173
Gene Symbol:
IL1RL1
IL1RL1
Asthma
A
0.700
GeneticVariation
GWASCAT
Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct.
30929738
2019
rs12479210
IL18R1;IL1RL1
Asthma
T
0.700
GeneticVariation
GWASCAT
Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study.
30552067
2019
rs1861245
IL18R1;IL1RL1
Asthma
C
0.700
GeneticVariation
GWASCAT
Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct.
30929738
2019
rs3771175
IL18R1;IL1RL1
Asthma
T
0.700
GeneticVariation
GWASCAT
Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.
31036433
2019
rs72823641
IL18R1;IL1RL1
Asthma
T
0.700
GeneticVariation
GWASCAT
Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct.
30929738
2019
rs72823641
IL18R1;IL1RL1
Asthma
T
0.700
GeneticVariation
GWASCAT
Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis.
31619474
2019
rs72823641
IL18R1;IL1RL1
Asthma
0.700
GeneticVariation
GWASCAT
A genome-wide cross-trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases.
29785011
2018
rs10208293
IL18R1;IL1RL1
Asthma
G
0.700
GeneticVariation
GWASCAT
Identification of a new locus at 16q12 associated with time to asthma onset.
27130862
2016
rs10173081
IL18R1;IL1RL1
Asthma
0.700
GeneticVariation
GWASDB
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
21804549
2011
rs13408569
IL18R1;IL1RL1
Asthma
0.700
GeneticVariation
GWASDB
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
21804549
2011
rs13431828
IL18R1;IL1RL1
Asthma
0.700
GeneticVariation
GWASDB
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.
21804549
2011
rs10204137
IL18R1;IL1RL1
Asthma
0.700
GeneticVariation
GWASDB
A large-scale, consortium-based genomewide association study of asthma.
20860503
2010
rs10206753
IL18R1;IL1RL1
Asthma
0.700
GeneticVariation
GWASDB
A large-scale, consortium-based genomewide association study of asthma.
20860503
2010
rs13431828
IL18R1;IL1RL1
Asthma
0.700
GeneticVariation
GWASDB
A large-scale, consortium-based genomewide association study of asthma.
20860503
2010
rs10192157
IL18R1;IL1RL1
Asthma
0.710
GeneticVariation
BEFREE
However, the rs10192157 and rs2899642 mutations were documented with asthma disease.
31213409
2020
rs1420101
IL18R1;IL1RL1
Asthma
T
0.710
GeneticVariation
GWASCAT
Large-scale, multiethnic genome-wide association study identifies novel loci contributing to asthma susceptibility in adults.
30578877
2019
rs1420101
IL18R1;IL1RL1
Asthma
T
0.710
GeneticVariation
GWASCAT
Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks.
29273806
2018
rs1420101
IL18R1;IL1RL1
Asthma
0.710
GeneticVariation
BEFREE
Finally, we determined the association of IL1RL1-a levels with asthma and its clinical characteristics (n=1101).<i>IL1RL1</i> asthma -risk SNPs strongly associated with <i>IL1RL1</i> methylation (rs1420101 ; p=3.7×10<sup>-16</sup>) and serum IL1RL1-a levels (p=2.8×10<sup>-56</sup>).
29519908
2018
rs10192157
IL18R1;IL1RL1
Asthma
0.710
GeneticVariation
GWASDB
A large-scale, consortium-based genomewide association study of asthma.
20860503
2010
rs10197862
IL18R1;IL1RL1
Asthma
A
0.810
GeneticVariation
GWASCAT
Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.
24388013
2014
rs13408661
IL18R1;IL1RL1
Asthma
G
0.810
GeneticVariation
GWASCAT
We also identified two genome-wide significant associations: rs13408661 near IL1RL1/IL18R1 (P(Stage1+Stage2) = 1.1x10(-9)), which is correlated with a variant recently shown to be associated with asthma (rs3771180), and rs9268516 in the HLA region (P(Stage1+Stage2) = 1.1x10(-8)), which appears to be independent of previously reported associations in this locus.
23028483
2012
rs13408661
IL18R1;IL1RL1
Asthma
G
0.810
GeneticVariation
GWASDB
We also identified two genome-wide significant associations: rs13408661 near IL1RL1/IL18R1 (P(Stage1+Stage2) = 1.1x10(-9)), which is correlated with a variant recently shown to be associated with asthma (rs3771180), and rs9268516 in the HLA region (P(Stage1+Stage2) = 1.1x10(-8)), which appears to be independent of previously reported associations in this locus.
23028483
2012