GPR50, G protein-coupled receptor 50, 9248

N. diseases: 31; N. variants: 4
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs13440581
rs13440581
Entrez Id: 9248
Gene Symbol: GPR50
GPR50
CUI: C0344315
Disease:
Depressed mood
0.010 GeneticVariation BEFREE Women heterozygous for rs13440581, had a 1.6-fold increased risk of baseline depression, while the odds of depression comorbid with anxiety were increased fourfold for women homozygous for the minor allele of rs2072621. 25798330 2015
dbSNP: rs13440581
rs13440581
Entrez Id: 9248
Gene Symbol: GPR50
GPR50
CUI: C0003467
Disease:
Anxiety
0.010 GeneticVariation BEFREE Women heterozygous for rs13440581, had a 1.6-fold increased risk of baseline depression, while the odds of depression comorbid with anxiety were increased fourfold for women homozygous for the minor allele of rs2072621. 25798330 2015
dbSNP: rs13440581
rs13440581
Entrez Id: 9248
Gene Symbol: GPR50
GPR50
CUI: C0011570
Disease:
Mental Depression
0.010 GeneticVariation BEFREE Women heterozygous for rs13440581, had a 1.6-fold increased risk of baseline depression, while the odds of depression comorbid with anxiety were increased fourfold for women homozygous for the minor allele of rs2072621. 25798330 2015
dbSNP: rs13440581
rs13440581
Entrez Id: 9248
Gene Symbol: GPR50
GPR50
CUI: C0011581
Disease:
Depressive disorder
0.010 GeneticVariation BEFREE Women heterozygous for rs13440581, had a 1.6-fold increased risk of baseline depression, while the odds of depression comorbid with anxiety were increased fourfold for women homozygous for the minor allele of rs2072621. 25798330 2015
dbSNP: rs13440581
rs13440581
Entrez Id: 9248
Gene Symbol: GPR50
GPR50
CUI: C0003469
Disease:
Anxiety Disorders
0.010 GeneticVariation BEFREE Women heterozygous for rs13440581, had a 1.6-fold increased risk of baseline depression, while the odds of depression comorbid with anxiety were increased fourfold for women homozygous for the minor allele of rs2072621. 25798330 2015
dbSNP: rs2072621
rs2072621
Entrez Id: 9248;100128688
Gene Symbol: GPR50;GPR50-AS1
GPR50;GPR50-AS1
CUI: C0011581
Disease:
Depressive disorder
0.010 GeneticVariation BEFREE Women heterozygous for rs13440581, had a 1.6-fold increased risk of baseline depression, while the odds of depression comorbid with anxiety were increased fourfold for women homozygous for the minor allele of rs2072621. 25798330 2015
dbSNP: rs2072621
rs2072621
Entrez Id: 9248;100128688
Gene Symbol: GPR50;GPR50-AS1
GPR50;GPR50-AS1
CUI: C0003467
Disease:
Anxiety
0.010 GeneticVariation BEFREE Women heterozygous for rs13440581, had a 1.6-fold increased risk of baseline depression, while the odds of depression comorbid with anxiety were increased fourfold for women homozygous for the minor allele of rs2072621. 25798330 2015
dbSNP: rs2072621
rs2072621
Entrez Id: 9248;100128688
Gene Symbol: GPR50;GPR50-AS1
GPR50;GPR50-AS1
CUI: C0003469
Disease:
Anxiety Disorders
0.010 GeneticVariation BEFREE Women heterozygous for rs13440581, had a 1.6-fold increased risk of baseline depression, while the odds of depression comorbid with anxiety were increased fourfold for women homozygous for the minor allele of rs2072621. 25798330 2015
dbSNP: rs2072621
rs2072621
Entrez Id: 9248;100128688
Gene Symbol: GPR50;GPR50-AS1
GPR50;GPR50-AS1
CUI: C0011570
Disease:
Mental Depression
0.010 GeneticVariation BEFREE Women heterozygous for rs13440581, had a 1.6-fold increased risk of baseline depression, while the odds of depression comorbid with anxiety were increased fourfold for women homozygous for the minor allele of rs2072621. 25798330 2015
dbSNP: rs2072621
rs2072621
Entrez Id: 9248;100128688
Gene Symbol: GPR50;GPR50-AS1
GPR50;GPR50-AS1
CUI: C0344315
Disease:
Depressed mood
0.010 GeneticVariation BEFREE Women heterozygous for rs13440581, had a 1.6-fold increased risk of baseline depression, while the odds of depression comorbid with anxiety were increased fourfold for women homozygous for the minor allele of rs2072621. 25798330 2015
dbSNP: rs561077
rs561077
Entrez Id: 9248
Gene Symbol: GPR50
GPR50
CUI: C0011581
Disease:
Depressive disorder
0.010 GeneticVariation BEFREE In contrast, rs561077 was associated with a 1.8-fold increased risk of incident depression specifically. 25798330 2015
dbSNP: rs561077
rs561077
Entrez Id: 9248
Gene Symbol: GPR50
GPR50
CUI: C0011570
Disease:
Mental Depression
0.010 GeneticVariation BEFREE In contrast, rs561077 was associated with a 1.8-fold increased risk of incident depression specifically. 25798330 2015
dbSNP: rs561077
rs561077
Entrez Id: 9248
Gene Symbol: GPR50
GPR50
CUI: C0344315
Disease:
Depressed mood
0.010 GeneticVariation BEFREE In contrast, rs561077 was associated with a 1.8-fold increased risk of incident depression specifically. 25798330 2015
dbSNP: rs2072621
rs2072621
Entrez Id: 9248;100128688
Gene Symbol: GPR50;GPR50-AS1
GPR50;GPR50-AS1
CUI: C0525045
Disease:
Mood Disorders
0.010 GeneticVariation BEFREE Association of the intronic rs2072621 polymorphism of the X-linked GPR50 gene with affective disorder with seasonal pattern. 21565467 2012
dbSNP: rs2072621
rs2072621
Entrez Id: 9248;100128688
Gene Symbol: GPR50;GPR50-AS1
GPR50;GPR50-AS1
CUI: C0085159
Disease:
Seasonal Affective Disorder
0.010 GeneticVariation BEFREE This case-control study found an association between Seasonal Affective Disorder (SAD) and a single nucleotide polymorphism (intronic rs2072621) of the gene encoding GPR50 (an orphan member of the G protein-coupled melatonin receptor subfamily) in females. 21565467 2012
dbSNP: rs1202874
rs1202874
Entrez Id: 9248;100128688
Gene Symbol: GPR50;GPR50-AS1
GPR50;GPR50-AS1
CUI: C0005586
Disease:
Bipolar Disorder
0.010 GeneticVariation BEFREE To our knowledge this is the first association of rs1202874 with BD and is the second positive association at the GPR50 locus. 20371266 2010
dbSNP: rs561077
rs561077
Entrez Id: 9248
Gene Symbol: GPR50
GPR50
CUI: C1510586
Disease:
Autism Spectrum Disorders
0.010 GeneticVariation BEFREE Concerning GPR50, we detected a significant association between ASD and two variations, Delta502-505 and T532A, in affected males, but it did not hold up after Bonferonni correction for multiple testing. 20657642 2010