NRXN3, neurexin 3, 9369

N. diseases: 64; N. variants: 29
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1057519451
rs1057519451
Entrez Id: 9369;105370589
Gene Symbol: NRXN3;LOC105370589
NRXN3;LOC105370589
CUI: C0349588
Disease:
Short stature 		G 0.700 CausalMutation CLINVAR
dbSNP: rs1057519451
rs1057519451
Entrez Id: 9369;105370589
Gene Symbol: NRXN3;LOC105370589
NRXN3;LOC105370589
CUI: C1849075
Disease:
Relative macrocephaly 		G 0.700 CausalMutation CLINVAR
dbSNP: rs531047390
rs531047390
Entrez Id: 9369
Gene Symbol: NRXN3
NRXN3
CUI: C1849075
Disease:
Relative macrocephaly 		G 0.700 CausalMutation CLINVAR
dbSNP: rs531047390
rs531047390
Entrez Id: 9369
Gene Symbol: NRXN3
NRXN3
CUI: C0349588
Disease:
Short stature 		G 0.700 CausalMutation CLINVAR
dbSNP: rs10146997
rs10146997
Entrez Id: 9369
Gene Symbol: NRXN3
NRXN3
CUI: C0455829
Disease:
Waist Circumference 		G 0.800 GeneticVariation GWASDB In stage 1, 31,373 individuals of Caucasian descent from eight cohort studies confirmed the role of FTO and MC4R and identified one novel locus associated with WC in the neurexin 3 gene [NRXN3 (rs10146997, p = 6.4x10(-7))]. 19557197 2009
dbSNP: rs10146997
rs10146997
Entrez Id: 9369
Gene Symbol: NRXN3
NRXN3
CUI: C0455829
Disease:
Waist Circumference 		G 0.800 GeneticVariation GWASCAT In stage 1, 31,373 individuals of Caucasian descent from eight cohort studies confirmed the role of FTO and MC4R and identified one novel locus associated with WC in the neurexin 3 gene [NRXN3 (rs10146997, p = 6.4x10(-7))]. 19557197 2009
dbSNP: rs7144011
rs7144011
Entrez Id: 9369
Gene Symbol: NRXN3
NRXN3
CUI: C0455829
Disease:
Waist Circumference 		0.800 GeneticVariation GWASDB NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium. 19557197 2009
dbSNP: rs10145154
rs10145154
Entrez Id: 9369
Gene Symbol: NRXN3
NRXN3
CUI: C0455829
Disease:
Waist Circumference 		0.700 GeneticVariation GWASDB NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium. 19557197 2009
dbSNP: rs10150332
rs10150332
Entrez Id: 9369
Gene Symbol: NRXN3
NRXN3
CUI: C0455829
Disease:
Waist Circumference 		0.700 GeneticVariation GWASDB NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium. 19557197 2009
dbSNP: rs17109256
rs17109256
Entrez Id: 9369
Gene Symbol: NRXN3
NRXN3
CUI: C0455829
Disease:
Waist Circumference 		0.700 GeneticVariation GWASDB NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium. 19557197 2009
dbSNP: rs1396618
rs1396618
Entrez Id: 9369
Gene Symbol: NRXN3
NRXN3
CUI: C1519383
Disease:
Smoking Behaviors 		0.700 GeneticVariation GWASDB Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. 20418888 2010
dbSNP: rs10150332
rs10150332
Entrez Id: 9369
Gene Symbol: NRXN3
NRXN3
CUI: C0578022
Disease:
Finding of body mass index 		C 0.700 GeneticVariation GWASDB Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. 20935630 2010
dbSNP: rs10150332
rs10150332
Entrez Id: 9369
Gene Symbol: NRXN3
NRXN3
CUI: C1305855
Disease:
Body mass index 		C 0.700 GeneticVariation GWASCAT Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. 20935630 2010
dbSNP: rs10150332
rs10150332
Entrez Id: 9369
Gene Symbol: NRXN3
NRXN3
CUI: C0005893
Disease:
Body mass index procedure 		C 0.700 GeneticVariation GWASDB Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. 20935630 2010
dbSNP: rs11624704
rs11624704
Entrez Id: 9369
Gene Symbol: NRXN3
NRXN3
CUI: C0028754
Disease:
Obesity 		0.800 GeneticVariation GWASDB We next examined obesity-related quantitative traits (such as total body weight, waist circumference and waist to hip ratio), and detected genome-wide significant signals between waist to hip ratio and NRXN3 (rs11624704, P = 2.67 × 10(-9)), previously associated with body weight and fat distribution. 21552555 2011
dbSNP: rs11624704
rs11624704
Entrez Id: 9369
Gene Symbol: NRXN3
NRXN3
CUI: C0028754
Disease:
Obesity 		0.800 GeneticVariation GWASCAT We next examined obesity-related quantitative traits (such as total body weight, waist circumference and waist to hip ratio), and detected genome-wide significant signals between waist to hip ratio and NRXN3 (rs11624704, P = 2.67 × 10(-9)), previously associated with body weight and fat distribution. 21552555 2011
dbSNP: rs10146997
rs10146997
Entrez Id: 9369
Gene Symbol: NRXN3
NRXN3
CUI: C0028754
Disease:
Obesity 		0.010 GeneticVariation BEFREE The minor G-allele of rs10146997 in NRXN3 associated with increased WC among women (β = 0.55cm (0.20;0.89), p(additive) = 1.7×10(-3), p(interaction) = 1.0×10(-3)), but showed no associations with obesity related metabolic traits. 21674055 2011
dbSNP: rs1004212
rs1004212
Entrez Id: 9369
Gene Symbol: NRXN3
NRXN3
CUI: C0549393
Disease:
Alcohol problem 		0.010 GeneticVariation BEFREE In men, there were modest associations between rs11624704 and attentional impulsivity (p=0.005) and between rs1004212 and alcohol problems (p=0.009). 21676558 2011
dbSNP: rs1004212
rs1004212
Entrez Id: 9369
Gene Symbol: NRXN3
NRXN3
CUI: C0021125
Disease:
Impulsive Behavior 		0.010 GeneticVariation BEFREE In men, there were modest associations between rs11624704 and attentional impulsivity (p=0.005) and between rs1004212 and alcohol problems (p=0.009). 21676558 2011
dbSNP: rs11624704
rs11624704
Entrez Id: 9369
Gene Symbol: NRXN3
NRXN3
CUI: C0549393
Disease:
Alcohol problem 		0.010 GeneticVariation BEFREE In men, there were modest associations between rs11624704 and attentional impulsivity (p=0.005) and between rs1004212 and alcohol problems (p=0.009). 21676558 2011
dbSNP: rs11624704
rs11624704
Entrez Id: 9369
Gene Symbol: NRXN3
NRXN3
CUI: C0021125
Disease:
Impulsive Behavior 		0.010 GeneticVariation BEFREE In men, there were modest associations between rs11624704 and attentional impulsivity (p=0.005) and between rs1004212 and alcohol problems (p=0.009). 21676558 2011
dbSNP: rs10146997
rs10146997
Entrez Id: 9369
Gene Symbol: NRXN3
NRXN3
CUI: C0006142
Disease:
Malignant neoplasm of breast 		0.010 GeneticVariation BEFREE Moreover, G allele carriers in rs10146997 of the NRXN3 gene were the youngest patients at onset of breast cancer</span>. 21688152 2012
dbSNP: rs10146997
rs10146997
Entrez Id: 9369
Gene Symbol: NRXN3
NRXN3
CUI: C0678222
Disease:
Breast Carcinoma 		0.010 GeneticVariation BEFREE Moreover, G allele carriers in rs10146997 of the NRXN3 gene were the youngest patients at onset of breast cancer</span>. 21688152 2012
dbSNP: rs3850370
rs3850370
Entrez Id: 9369
Gene Symbol: NRXN3
NRXN3
CUI: C0007131
Disease:
Non-Small Cell Lung Carcinoma 		0.010 GeneticVariation BEFREE The minor allele of three SNPs (rs7629386 at 3p22.1, rs969088 at 5p14.1, and rs3850370 at 14q24.3) were associated with worse NSCLC survival while 2 (rs41997 at 7q31.31 and rs12000445 at 9p21.3) were associated with better NSCLC survival. 22872573 2012
dbSNP: rs10150332
rs10150332
Entrez Id: 9369
Gene Symbol: NRXN3
NRXN3
CUI: C0578022
Disease:
Finding of body mass index 		0.700 GeneticVariation GWASDB Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals. 23001569 2013