To assess whether MTHFR gene polymorphism (C677T) by causing hyperhomocysteinemia affects the retinal AVR in type 2 diabetic and non-diabetic subjects.
Next generation sequencing (NGS) showed polymorphism in CFH (p.V62I in SCR1) and THBD (p.A473V), already known as pathogenic for C3GN, as well as a mutation in C3 (p.R102G) associated only with age-related macular degeneration (AMD) so far.
Among them, rs6461639 (interaction P=1.88 × 10<sup>-5</sup> in the CAMP population) showed a significant association with the final BMD Z-scores in the ALL population (P=0.016).
Among them, rs6461639 (interaction P=1.88 × 10<sup>-5</sup> in the CAMP population) showed a significant association with the final BMD Z-scores in the ALL population (P=0.016).
Among them, rs6461639 (interaction P=1.88 × 10<sup>-5</sup> in the CAMP population) showed a significant association with the final BMD Z-scores in the ALL population (P=0.016).